Search results

151. In vitro and in vivo studies on iminosugars as inhibitors of the biofilm formation by various bacteria pathogenic for hu…

Principal investigator: prof. Piotr Bogumił Heczko

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Call: OPUS 16, Panel: NZ6

152. Deciphering molecular mechanism of CDK8 kinase inhibitors action in acute myeloid leukemia

Principal investigator: dr hab. Michał Marek Mikula

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Call: SONATA BIS 8, Panel: NZ2

153. Multifunctional ligands - TRPA1 channel antagonists and phosphodiesterases inhibitors as a new approach for the treatmen…

Principal investigator: prof. Grażyna Chłoń-Rzepa

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 15, Panel: NZ7

154. The influence of perinatal exposure to selective serotonin reuptake inhibitors on the structure and functions of mice do…

Principal investigator: prof. Grzegorz Władysław Hess

Instytut Farmakologii PAN

Call: OPUS 14, Panel: NZ4

155. Studies of alkylation mechanism of DNA oligomers using new Top I inhibitors from camptothecin family by physical organic…

Principal investigator: prof. Lech Jan Kozerski

Narodowy Instytut Leków

Call: OPUS 14, Panel: ST4

156. Small-molecule inhibitors for characterization of the interaction between extracellular domains of Programmed Cell Death…

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Call: MAESTRO 9, Panel: ST5

157. Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome i…

Principal investigator: prof. Jakub Adam Gołąb

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Call: OPUS 13, Panel: NZ6

158. Optical and time-resolved spectroscopy for hypothesis veryfication of the conducting by mTS the reductive reaction with …

Principal investigator: Małgorzata Katarzyna Prokopowicz

Uniwersytet Warszawski, Wydział Fizyki

Call: PRELUDIUM 13, Panel: NZ1

159. Design of new small molecular regulators (inhibitors, activators) of the catalytic activity of adenylate kinases. Molecu…

Principal investigator: dr Anna Kozakiewicz-Piekarz

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Call: OPUS 13, Panel: ST4

160. Development of HTS method based on fluorescently labelled guanosine analogues: novel route for RNA (guanosine-N7)-methyl…

Principal investigator: Renata Kasprzyk

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: PRELUDIUM 12, Panel: ST4

161. Evaluation of primary and secondary molecular disorders determinig drug resistance from a group of proteasome inhibitors…

Principal investigator: prof. Tadeusz Jerzy Robak

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Call: OPUS 12, Panel: NZ5

162. Inhibitors of anti-apoptotic proteins from the BCL-2 family as agents enhancing BRAFV600E inhibition in melanoma cells.

Principal investigator: dr Mariusz Hartman

Uniwersytet Medyczny w Łodzi, Międzywydziałowa Katedra Chemii i Biochemii Medycznej

Call: SONATA 12, Panel: NZ7

163. New mulitple target-directed ligands - A1/A2A adenosine receptors antagonists and monoamine oxidase B inhibitors - searc…

Principal investigator: Michał Karol Załuski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: PRELUDIUM 12, Panel: NZ7

164. Evaluation of SLC22A5 activity modulation in sensitizing glioma cells to the suppression of fatty acid oxidation by CPT1…

Principal investigator: Barbara Elżbieta Juraszek

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Call: PRELUDIUM 12, Panel: NZ3

165. The alterations of lipid metabolism in colorectal cancer - their role in the development of disease and the asessment of…

Principal investigator: dr hab. Tomasz Śledziński

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Call: SONATA BIS 6, Panel: NZ4

166. New amide derivatives of cinnamic acid as a carbonyl reductase inhibitors, which modulate the activity of doxorubicin - …

Principal investigator: dr Paulina Koczurkiewicz-Adamczyk

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: SONATA 11, Panel: NZ7

167. Molecular aspects of interference with the thymidylate synthase-catalyzed reaction mechanism by the slow-binding inhibit…

Principal investigator: prof. Wojciech Krzysztof Rode

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

Call: OPUS 11, Panel: NZ1

168. Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the …

Principal investigator: Julia Witkowska

Uniwersytet Gdański, Wydział Chemii

Call: PRELUDIUM 9, Panel: NZ1

169. Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese…

Principal investigator: prof. Maria Wanda Bretner

Politechnika Warszawska, Wydział Chemiczny

Call: OPUS 9, Panel: ST5

170. New MOF compounds as degradable nanocontainers of tyrosine kinases inhibitors in novel anti-cancer therapy

Principal investigator: prof. Artur Piotr Terzyk

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Call: OPUS 9, Panel: ST5

171. The use of microRNA inhibitors for restoration of the expression of tumor suppressor, gene SLC5A8, and establishing of t…

Principal investigator: Wojciech Gierlikowski

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Call: PRELUDIUM 9, Panel: NZ2

172. Novel dual PDE4 and PDE7 inhibitors in a group of purine and deazapurine derivatives - perspective for the treatment of …

Principal investigator: prof. Maciej Henryk Pawłowski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 8, Panel: NZ7

173. Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono…

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Call: SONATA BIS 4, Panel: ST5

174. COX-2 inhibitors and/or PPAR agonists-conjugated PAMAM G3 dendrimers targeted into cancer cells. Biological properties a…

Principal investigator: dr Łukasz Stanisław Uram

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

Call: SONATA 7, Panel: NZ3

175. Understanding the mechanism of action for small molecule kinase inhibitors in alleviating myotonic dystrophy type 1 (DM1…

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej PAN

Call: OPUS 7, Panel: NZ5

176. Novel polyelectrolytes as potential inhibitors of HSV-1 virus - synthesis, properties and mechanism of action

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Call: OPUS 7, Panel: ST5

177. Evaluation of the immunomodulatory activity of cefazolin as a potential inhibitor of proinflammatory cytokines which bin…

Principal investigator: dr Barbara Joanna Żyżyńska-Granica

Warszawski Uniwersytet Medyczny, Wydział Nauki o Zdrowiu z Oddziałem Pielęgniarstwa, Oddziałem Zdrowia Publicznego i Oddziałem Dietetyki

Call: PRELUDIUM 7, Panel: NZ7

178. Transient protein states in designing small-molecule inhibitors of protein-protein interactions

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Call: SYMFONIA 2, Panel: NZ1

179. Endogenous enkephalinase inhibitors and their novel synthetic analogs as potential new therapeutics for the treatment of…

Principal investigator: dr hab. Jakub Jerzy Fichna

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Call: OPUS 6, Panel: NZ7

180. New 1,3,4-thiadiazole derivatives as inhibitors of critical steps of the glutamine-glutamate cycle in glioblastoma cells…

Principal investigator: dr hab. Monika Paulina Szeliga

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Call: SONATA 6, Panel: NZ7

181. Inhibitors of ER stress dependant PERK kinase as a novel approach for Alzheimer's therapy

Principal investigator: prof. Ireneusz Jacek Majsterek

Uniwersytet Medyczny w Łodzi, Wydział Wojskowo-Lekarski

Call: HARMONIA 5, Panel: NZ1

182. Conjugates of prion protein with dendrimers as inhibitors of Abeta peptide amyloidogenesis and cytotoxicity of potential…

Principal investigator: dr hab. Krzysztof Nieznański

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Call: HARMONIA 5, Panel: NZ4

183. Effect of aliskiren, a renin inhibitor, on the anticonvulsant activity of antiepileptic drugs in three seizure tests in …

Principal investigator: dr Krzysztof Łukawski

Instytut Medycyny Wsi im. Witolda Chodźki

Call: OPUS 5, Panel: NZ7

184. The active center and beyond: towards new selective inhibitors of S-adenosyl-L-homocysteine hydrolase. Structural enzymo…

Principal investigator: dr Krzysztof Brzeziński

Uniwersytet w Białymstoku, Wydział Biologiczno-Chemiczny

Call: OPUS 5, Panel: NZ1

185. New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in…

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: OPUS 5, Panel: ST5

186. The role of neutral endopeptidase (NEP) and its inhibitor, sialorphin, in colon cancer cells biology.

Principal investigator: prof. Martyna Maria Kandefer-Szerszeń

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Call: OPUS 4, Panel: NZ3

187. Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

Principal investigator: dr Monika Katarzyna Łęgowska

Uniwersytet Gdański, Wydział Chemii

Call: PRELUDIUM 4, Panel: ST5

188. Synthesis and analysis of potential furin inhibitors in the development of the new therapeutic strategies against viral …

Principal investigator: Monika Aleksandra Lewandowska-Goch

Uniwersytet Gdański, Wydział Chemii

Call: PRELUDIUM 4, Panel: ST5

189. Effect of deimination of essential arginine residues on the function of protease inhibitors and other components of inna…

Principal investigator: dr Tomasz Kantyka

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Call: OPUS 3, Panel: NZ6

190. Impact of combined therapy of non-steroidal anti-inflammatory drugs and selective serotonin reuptake inhibitors on oxida…

Principal investigator: dr hab. Piotr Gałecki

Uniwersytet Medyczny w Łodzi, Wydział Wojskowo-Lekarski; Klinika Psychiatrii Dorosłych

Call: OPUS 3, Panel: NZ5

191. Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit…

Principal investigator: Ewelina Marta Węglarz-Tomczak

Politechnika Wrocławska, Wydział Chemiczny

Call: PRELUDIUM 3, Panel: ST5

192. Evaluation of pharmacological activity of new, nonselective gamma-aminobutyric acid (GABA) transport inhibitors in some …

Principal investigator: dr hab. Kinga Sałat

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 3, Panel: NZ7

193. Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

Principal investigator: dr Karolina Ewa Piecyk

Uniwersytet Warszawski, Wydział Chemii

Call: PRELUDIUM 3, Panel: ST5

194. Novel urease inhibitors as means to control ureolytic microbial pathogens

Principal investigator: dr Agnieszka Grabowiecka

Politechnika Wrocławska

Call: OPUS 2, Panel: NZ6

195. Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Call: OPUS 2, Panel: ST5

196. Inhibitors of serine proteases as regulators of dendritic cell function.

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Call: MAESTRO 1, Panel: NZ5

197. Significance of the TNF, TNFR1, TNFR2, TRAF1, TRAF6 and TACE gene polymorphisms, clinical parameters and biomarkers for …

Principal investigator: dr hab. Jerzy Piotr Świerkot

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarski

Call: OPUS 1, Panel: NZ5

198. 3D structure-based search for selective inhibitor of thymidylate synthase of nematodes, a potential drug in chemotherapy…

Principal investigator: prof. Wojciech Krzysztof Rode

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Call: OPUS 1, Panel: NZ6

199. Phenolic compounds as pancreatic lipase inhibitors

Principal investigator: dr Anna Danuta Podsędek

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

Call: OPUS 1, Panel: NZ9

200. Discovery and development of small-molecule inhibitors of USP2 for targeted, non-genotoxic therapy of cancer

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Call: OPUS 1, Panel: ST5

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