Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Understanding the mechanism of action for small molecule kinase inhibitors in alleviating myotonic dystrophy type 1 (DM1) pathomechanism.

2014/13/B/NZ5/03214

Keywords:

DM1 pathomechanism toxic RNA microsatellites protein kinases,

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marzena Wojciechowska 

Number of co-investigators in the project: 4

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 665 840 PLN

Project start date (Y-m-d): 2015-03-11

Project end date (Y-m-d): 2019-07-10

Project duration:: 52 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer wraz z oprogramowaniem.
  2. Dysk wewnętrzny (372 PLN)
  3. Komputer wraz zoprogramowaniem (10 000 PLN)
  4. aparat do elektroforezy zelowej bialkowej (2 szt.) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Small Molecules Which Improve Pathogenesis of Myotonic Dystrophy Type 1
    Authors:
    López-Morató M, Brook JD, Wojciechowska M
    Academic press:
    Frontiers in Neurology (rok: 2018, tom: 9, strony: 45303), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fneur.2018.00349 - link to the publication
  2. Global increase in circRNA levels in myotonic dystrophy
    Authors:
    Karol Czubak, Katarzyna Taylor, Agnieszka Piasecka, Krzysztof Sobczak, Katarzyna Kozłowska, Anna Philips, Saam Sedehizadeh, John David Brook, Marzena Wojciechowska, Kozlowski Piotr
    Academic press:
    Frontiers in Genetics (rok: 2019, tom: 10, strony: brak), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fgene.2019.00649 - link to the publication
  3. An overview of circular RNAs and their implications in myotonic dystrophy type 1 (DM1)
    Authors:
    Karol Czubak, Saam Sedehizadeh, Piotr Kozlowski, Marzena Wojciechowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: brak), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20184385 - link to the publication
  4. CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model
    Authors:
    Ami Ketley, Marzena Wojciechowska, Sonja Ghidelli-Disse, Paul Bamborough, Tushar K Ghosh, Marta Lopez Morato, Saam Sedehizadeh, Naveed Altaf Malik, Zhenzhi Tang, Paulina Powalowska, Matthew Tanner, Markus Bösche, Marcus Bantscheff, Martin Rüdiger, Danuta E Mossakowska, David H Drewry, William J Zuercher, Charles A Thornton, Gerard Drewes, Iain Uings, Christopher J. Hayes, J David Brook
    Academic press:
    Science Translation Medicine (rok: 2020, tom: 12, strony: brak), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/scitranslmed.aaz2415 - link to the publication
  5. Quantitative Methods to Monitor RNA Biomarkers in Myotonic Dystrophy
    Authors:
    Marzena Wojciechowska, Krzysztof Sobczak, Piotr Kozlowski, Saam Sedehizadeh, Agnieszka Wojtkowiak-Szlachcic, Karol Czubak, Robert Markus , Anna Lusakowska, Anna Kaminska and John D. Brook
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 5885), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-24156-x - link to the publication
  1. PROTEIN KINASE INHIBITORS AS POTENTIAL THERAPEUTIC AGENTS TO AMELIORATE PATHOGENESIS OF MYOTONIC DYSTROPHY TYPE 1 (DM1)
    Authors:
    Marzena Wojciechowska and Piotr Kozlowski
    Book:
    Myotonic Dystrophies: Epidemiology, Diagnosis and Therapeutic Challenges (rok: 2015, tom: 1, strony: 45303), Wydawca: NOVA SCIENCE PUBLISHERS, INC.
    Status:
    Published

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