Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for inhibitors of cap-structure-recognizing proteins with terapheutic relevance

2013/09/B/ST5/01341

Keywords:

synthesis of nucleotides fluorescent labels bioorganic chemistry

Descriptors:

  • ST5_16:
  • NZ1_3: Biophysics
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jacek Jemielity 

Number of co-investigators in the project: 9

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 993 000 PLN

Project start date (Y-m-d): 2014-02-14

Project end date (Y-m-d): 2017-02-13

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Spektrofluorymetr z opcją odczytu fluorescencji na 96-dołkowych płytkach (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Amino-functionalized 5' cap analogs as tools for site-specific sequence- independent labeling of messenger RNA
    Authors:
    Marcin Warminski, Pawel J. Sikorski, Zofia Warminska, Maciej Lukaszewicz, Anna Kropiwnicka, Joanna Zuberek, Edward Darzynkiewicz, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Bioconjugate Chemistry (rok: 2017, tom: 28, strony: 1978-1992), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.7b00291 - link to the publication
  2. Applications of Phosphate Modification and Labeling to Study (m)RNA Caps
    Authors:
    Marcin Warminski, Pawel J. Sikorski, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Topics in Current Chemistry (rok: 2017, tom: 375, strony: Article Number: 16), Wydawca: Springer International Publishing
    Status:
    Published
    DOI:
    10.1007/s41061-017-0106-y - link to the publication
  3. Gold-decorated polymer vessel structures as carriers of mRNA cap analogs
    Authors:
    Krystyna Kijewska, Paulina Głowala, Joanna Kowalska, Jacek Jemielity, Katarzyna Kaczyńska, Katarzyna Janiszewska, Jarosław Stolarski, Gary J. Blanchard, Daria Kępińska, Katarzyna Lubelska, Katarzyna Wiktorska, Marcin Pisarek, Maciej Mazur
    Academic press:
    Polymer (rok: 2015, tom: 57, strony: 77-87), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.polymer.2014.12.019 - link to the publication
  4. Phosphate-modified analogues of m7GTP and m7Gppppm7G – synthesis and biochemical properties
    Authors:
    Marcin Ziemniak, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Katarzyna Wnek, Edward Darzynkiewicz, Jacek Jemielity
    Academic press:
    Bioorganic & Medicinal Chemistry 23 (2015) 5369–5381 (rok: 2015, tom: 23, strony: 5369–5381), Wydawca: PERGAMON-ELSEVIER SCIENCE LTD
    Status:
    Published
    DOI:
    10.1016/j.bmc.2015.07.052 - link to the publication
  5. mRNA Cap Modification through Carbamate Chemistry: Synthesis of Aminoand Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation
    Authors:
    Marcin Warminski, Zofia Warminska, Joanna Kowalska, Jacek Jemielity
    Academic press:
    European Journal of Organic Chemistry (rok: 2015, tom: 2015, strony: 6153-6169), Wydawca: WILEY-V C H VERLAG GMBH
    Status:
    Published
    DOI:
    10.1002/ejoc.201500672 - link to the publication
  6. Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses
    Authors:
    Barbara Kroczynska, Gavin T. Blyth, Robert L. Rafidi, Beata Majchrzak-Kita, Lucy Xu, Diana Saleiro, Ewa M. Kosciuczuk, Jacek Jemielity, Bing Su, Jessica K. Altman, Elizabeth A. Eklund, Eleanor H. Fish, and Leonidas C. Platanias
    Academic press:
    The Journal of Biological Chemistry (rok: 2017, tom: brak, strony: brak), Wydawca: The American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M116.757666 - link to the publication
  7. Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring
    Authors:
    Renata Kasprzyk, Joanna Kowalska, Zbigniew Wieczorek, Mariusz Szabelski, Ryszard Stolarski, Jacek Jemielity
    Academic press:
    Organic & Biomolecular Chemistry (rok: 2016, tom: 14, strony: 3863-3868), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C6OB00419A - link to the publication
  8. Interferon γ (IFNγ)-Signaling via mTORC2 and Regulatory Effects in the Generation of Type II IFN Biological Responses
    Authors:
    Barbara Kroczynska, Robert L. Rafidi, Beata Majchrzak-Kita, Ewa M. Kosciuczuk, Gavin T. Blyth, Jacek Jemielity, Zofia Warminska, Diana Saleiro, Swarna Mehrotra, Ahmet Dirim Arslan, Eleanor N. Fish, Leonidas C. Platanias
    Academic press:
    JOURNAL OF BIOLOGICAL CHEMISTRY (rok: 2016, tom: 291, strony: 2389-2396), Wydawca: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
    Status:
    Published
    DOI:
    10.1074/jbc.M115.664995 - link to the publication
  9. Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex
    Authors:
    Marcin Ziemniak, Jeffrey S. Mugridge, Joanna Kowalska, Robert E. Rhoads, John D. Gross, Jacek Jemielity
    Academic press:
    RNA (rok: 2016, tom: 22, strony: 518-529), Wydawca: COLD SPRING HARBOR LAB PRESS
    Status:
    Published
    DOI:
    10.1261/rna.055152.115 - link to the publication
  10. eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation
    Authors:
    Kyung-Won Min, Sylvia Davila, Richard W. Zealy, Lawson T. Lloyd, In Young Lee, Rumi Lee, Kyung Hye Roh, Ahjin Jung, Jacek Jemielity, Eui-Ju Choi, Jeong Ho Chang, Je-Hyun Yoon
    Academic press:
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (rok: 2017, tom: 1860, strony: 761-772), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2017.05.002 - link to the publication

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