The active center and beyond: towards new selective inhibitors of S-adenosyl-L-homocysteine hydrolase. Structural enzymological studies.
2013/09/B/NZ1/01880
Keywords
Descriptors
- NZ1_4: Biologia strukturalna
- NZ1_9: Biotechnologia
- NZ1_10: Biologia drobnoustrojów
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet w Białymstoku, Wydział Biologiczno-Chemiczny
Voivodeship: podlaskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 5
Call
OPUS 5 – announced on 2013-03-15
- Amount awarded
- 502 065 PLN
- Project start date
- 2014-02-24
- Project end date
- 2018-02-23
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Mini-spektrofotometr UV-VIS. Cost: 60 000 PLN
Information in the final report
Publication in academic press/journals (3)
-
Crystal structure of S-adenosyl-L-homocysteine hydrolase from Cytophaga hutchinsonii, a case of combination of crystallographic and non-crystallographic symmetry
- Authors:
- Czyrko, J., Jaskolski, M., Brzezinski, K.
- Academic press:
- Croatica Chemica Acta (year: 2018, volume: 91(2), pages: 153-162), Publisher: Croatioan Chemical Society
- Status:
- Published
- DOI:
- 10.5562/cca3345 – link to the publication
-
Metal-cation regulation of enzyme dynamics is a key factor influencing the activity of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa
- Authors:
- Czyrko, J., Sliwiak, j., Imiolczyk, B., Gdaniec, Z., Jaskolski, M., Brzezinski, K.
- Academic press:
- Scientific Reports (year: 2018, volume: 8, pages: 11334), Publisher: Nature
- Status:
- Published
- DOI:
- 10.1038/s41598-018-29535-y – link to the publication
-
S-adenosyl-L-homocysteine hydrolase from a hyperthermophile (Thermotoga maritima) is expressed in Escherichia coli in inactive form - biochemical and structural studies
- Authors:
- Krzysztof Brzezinski, Justyna Czyrko, Joanna Sliwiak, Edyta Nalewajko-Sieliwoniuk, Mariusz Jaskolski, Boguslaw Nocek, Zbigniew Dauter
- Academic press:
- International Journal of Biological Macromolecules (year: 2017, volume: 104, pages: 584-596), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ijbiomac.2017.06.065 – link to the publication