Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The active center and beyond: towards new selective inhibitors of S-adenosyl-L-homocysteine hydrolase. Structural enzymological studies.

2013/09/B/NZ1/01880

Keywords:

S-adenosyl-L-homocysteine S-adenosyl-L-homocysteine hydrolase S-adenosyl-L-methionine methyltransferases protein crystalography

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_9: Biotechnology
  • NZ1_10: Microbiology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet w Białymstoku, Wydział Biologiczno-Chemiczny

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Krzysztof Brzeziński 

Number of co-investigators in the project: 5

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 502 065 PLN

Project start date (Y-m-d): 2014-02-24

Project end date (Y-m-d): 2018-02-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mini-spektrofotometr UV-VIS (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. S-adenosyl-L-homocysteine hydrolase from a hyperthermophile (Thermotoga maritima) is expressed in Escherichia coli in inactive form - biochemical and structural studies
    Authors:
    Krzysztof Brzezinski, Justyna Czyrko, Joanna Sliwiak, Edyta Nalewajko-Sieliwoniuk, Mariusz Jaskolski, Boguslaw Nocek, Zbigniew Dauter
    Academic press:
    International Journal of Biological Macromolecules (rok: 2017, tom: 104, strony: 584-596), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2017.06.065 - link to the publication
  2. Crystal structure of S-adenosyl-L-homocysteine hydrolase from Cytophaga hutchinsonii, a case of combination of crystallographic and non-crystallographic symmetry
    Authors:
    Czyrko, J., Jaskolski, M., Brzezinski, K.
    Academic press:
    Croatica Chemica Acta (rok: 2018, tom: 91(2), strony: 153-162), Wydawca: Croatioan Chemical Society
    Status:
    Published
    DOI:
    10.5562/cca3345 - link to the publication
  3. Metal-cation regulation of enzyme dynamics is a key factor influencing the activity of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa
    Authors:
    Czyrko, J., Sliwiak, j., Imiolczyk, B., Gdaniec, Z., Jaskolski, M., Brzezinski, K.
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 11334), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-29535-y - link to the publication

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