Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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Significance of the TNF, TNFR1, TNFR2, TRAF1, TRAF6 and TACE gene polymorphisms, clinical parameters and biomarkers for the efficacy of the treatment with TNF alfa inhibitors in patients with rheumatoid arthritis

2011/01/B/NZ5/05367

Keywords:

polymorphism TNF alfa rheumatoid arthritis

Descriptors:

  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jerzy Świerkot 

Number of co-investigators in the project: 8

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 279 600 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2014-11-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. Analysis of associations between polymorphisms within genes codingfor tumour necrosis factor (TNF)-alpha and TNF receptors andresponsiveness to TNF-alpha blockers in patients with rheumatoidarthritis
    Authors:
    Jerzy Swierkot, Katarzyna Bogunia-Kubik, Beata Nowak, Katarzyna Bialowas,Lucyna Korman, Katarzyna Gebura, Katarzyna Kolossa, Slawomir Jeka, Piotr Wilanda
    Academic press:
    Joint Bone Spine (rok: 2014, tom: in press, strony: in press), Wydawca: Elsevier Mason France
    Status:
    Published
    DOI:
    10.1016/j.jbspin.2014.08.006 - link to the publication
  2. IL-17A, IL-17F and IL-23R gene polymorphisms in rheumatoid arthritis
    Authors:
    Bogunia-Kubik K, Świerkot J, Malak A, Wysoczańska B, Nowak B, Białowąs K, Gębura K, Korman L, Wiland P
    Academic press:
    Arch Immunol Ther Exp (rok: 2015, tom: 63 (3), strony: 215-221), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-014-0319-5 - link to the publication
  3. Significance of association of HLA-C and HLA-E with psoriatic arthritis
    Authors:
    Renata Sokolik, Katarzyna Gebura , Milena Iwaszko, Jerzy Swierkot, Lucyna Korman, Piotr Wiland , Katarzyna Bogunia-Kubik
    Academic press:
    Human Immunology (rok: 2014, tom: 75, strony: 1188-1191), Wydawca: ELSEVIER
    Status:
    Published
  1. TNF-alfa, TNF receptor, HLA-E and NKG2A gene polymorphisms and response to anti TNF-alfa treatment in rheumatoid arthritis
    Authors:
    Swierkot J, Iwaszko M, Gebura K, Nowak B, Korman L, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K
    Conference:
    Annual European Congress of Rheumatology EULAR 2014 (rok: 2014, ), Wydawca: BMJ
    Data:
    konferencja 11-14.06.2014
    Status:
    Published
  2. ANALYSIS OF ASSOCIATIONS BETWEEN TUMOR NECROSIS FACTOR-ALPHA (TNFA -308 G>A, TNFA -238 G>A, TNFA -857 C>T) AND TNF RECEPTORS (TNFRA 36 A>G, TNFRB 676 T>G) GENE POLYMORPHISMS STATUS AND RESPONSIVENESS TO TNF-A BLOCKERS IN RHEUMATOID ARTHRITIS
    Authors:
    J. Swierkot, K. Bogunia-Kubik, B. Nowak, K. Bialowas, L. Korman, K. Gebura, K. Kolossa, S. Jeka, P. Wiland
    Conference:
    Annual European Congress of Rheumatology 2013 (rok: 2013, ), Wydawca: BMJ/Journals
    Data:
    konferencja czerwiec 2013
    Status:
    Published
  3. Wpływ polimorfizmu czynnika martwicy nowotworów TNF -308 G>A na skuteczność leczenia chorych na reumatoidalne zapalenie stawów inhibitorami TNF-alfa
    Authors:
    Świerkot J,Bogunia -Kubik K, Nowak B, Kolossa K, Białowąs K, Gębura K, Korman L, Jeka S, Wiland P
    Conference:
    IX Środkowoeuropejski Kongres Reumatologiczny CECR 2012 (rok: 2012, ), Wydawca: Termedia
    Data:
    konferencja 01-03.09. 2012
    Status:
    Published
  4. Czy oznaczenie polimorfizmów genów kodujących TNF-alfa i jego receptory może pomóc w personalizacji terapii chorych na RZS?
    Authors:
    J Świerkot, K. Bogunia- Kubik, B. Nowak, K. Białowąs, L.Korman, K.Gębura, K.Kolossa, S.Jeka, P. Wiland
    Conference:
    IV Krajowe Spotkania Reumatologiczne (rok: 2013, ), Wydawca: Skolamed
    Data:
    konferencja 12-14.09.2013
    Status:
    Published