Significance of the TNF, TNFR1, TNFR2, TRAF1, TRAF6 and TACE gene polymorphisms, clinical parameters and biomarkers for the efficacy of the treatment with TNF alfa inhibitors in patients with rheumatoid arthritis

2011/01/B/NZ5/05367

Keywords

Descriptors

  • NZ5_7: Leczenie chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarski

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Jerzy Piotr Świerkot

Number of co-investigators in the project: 8

Call

OPUS 1 – announced on 2011-03-15

Amount awarded
279 600 PLN
Project start date
2011-12-01
Project end date
2014-11-30
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (3)

  1. IL-17A, IL-17F and IL-23R gene polymorphisms in rheumatoid arthritis

    Authors:
    Bogunia-Kubik K, Świerkot J, Malak A, Wysoczańska B, Nowak B, Białowąs K, Gębura K, Korman L, Wiland P
    Academic press:
    Arch Immunol Ther Exp (year: 2015, volume: 63 (3), pages: 215-221), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-014-0319-5 – link to the publication
  2. Analysis of associations between polymorphisms within genes codingfor tumour necrosis factor (TNF)-alpha and TNF receptors andresponsiveness to TNF-alpha blockers in patients with rheumatoidarthritis

    Authors:
    Jerzy Swierkot, Katarzyna Bogunia-Kubik, Beata Nowak, Katarzyna Bialowas,Lucyna Korman, Katarzyna Gebura, Katarzyna Kolossa, Slawomir Jeka, Piotr Wilanda
    Academic press:
    Joint Bone Spine (year: 2014, volume: in press, pages: in press), Publisher: Elsevier Mason France
    Status:
    Published
    DOI:
    10.1016/j.jbspin.2014.08.006 – link to the publication
  3. Significance of association of HLA-C and HLA-E with psoriatic arthritis

    Authors:
    Renata Sokolik, Katarzyna Gebura , Milena Iwaszko, Jerzy Swierkot, Lucyna Korman, Piotr Wiland , Katarzyna Bogunia-Kubik
    Academic press:
    Human Immunology (year: 2014, volume: 75, pages: 1188-1191), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.humimm.2014.10.005 – link to the publication

Articles in post-conference publications (4)

  1. Wpływ polimorfizmu czynnika martwicy nowotworów TNF -308 G>A na skuteczność leczenia chorych na reumatoidalne zapalenie stawów inhibitorami TNF-alfa

    Authors:
    Świerkot J,Bogunia -Kubik K, Nowak B, Kolossa K, Białowąs K, Gębura K, Korman L, Jeka S, Wiland P
    Conference:
    IX Środkowoeuropejski Kongres Reumatologiczny CECR 2012 (year: 2012, pages: 72), Publisher: Termedia
    Date:
    conference 01-03.09. 2012
    Status:
    Published
  2. ANALYSIS OF ASSOCIATIONS BETWEEN TUMOR NECROSIS FACTOR-ALPHA (TNFA -308 G>A, TNFA -238 G>A, TNFA -857 C>T) AND TNF RECEPTORS (TNFRA 36 A>G, TNFRB 676 T>G) GENE POLYMORPHISMS STATUS AND RESPONSIVENESS TO TNF-A BLOCKERS IN RHEUMATOID ARTHRITIS

    Authors:
    J. Swierkot, K. Bogunia-Kubik, B. Nowak, K. Bialowas, L. Korman, K. Gebura, K. Kolossa, S. Jeka, P. Wiland
    Conference:
    Annual European Congress of Rheumatology 2013 (year: 2013, pages: 386), Publisher: BMJ/Journals
    Date:
    conference czerwiec 2013
    Status:
    Published
  3. Czy oznaczenie polimorfizmów genów kodujących TNF-alfa i jego receptory może pomóc w personalizacji terapii chorych na RZS?

    Authors:
    J Świerkot, K. Bogunia- Kubik, B. Nowak, K. Białowąs, L.Korman, K.Gębura, K.Kolossa, S.Jeka, P. Wiland
    Conference:
    IV Krajowe Spotkania Reumatologiczne (year: 2013, pages: 38), Publisher: Skolamed
    Date:
    conference 12-14.09.2013
    Status:
    Published
  4. TNF-alfa, TNF receptor, HLA-E and NKG2A gene polymorphisms and response to anti TNF-alfa treatment in rheumatoid arthritis

    Authors:
    Swierkot J, Iwaszko M, Gebura K, Nowak B, Korman L, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K
    Conference:
    Annual European Congress of Rheumatology EULAR 2014 (year: 2014, pages: 87-88), Publisher: BMJ
    Date:
    conference 11-14.06.2014
    Status:
    Published

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