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Information of the project and the call

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Evaluation of primary and secondary molecular disorders determinig drug resistance from a group of proteasome inhibitors (bortezomib, carfilzomib) and other anti myeloma drugs in patients with multiple myeloma

2016/23/B/NZ5/02529

Keywords:

multiple myeloma resistance molecular basis

Descriptors:

  • NZ5_5: Diagnostics in human diseases
  • NZ5_7: Human disease treatment
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tadeusz Robak 

Number of co-investigators in the project: 4

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 015 564 PLN

Project start date (Y-m-d): 2017-10-01

Project end date (Y-m-d): 2021-12-31

Project duration:: 51 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Book publications / chapters in book publications (1)
  1. The Prognostic Value of Whole-Blood PSMB5, CXCR4, POMP, and RPL5 mRNA Expression in Patients with Multiple Myeloma Treated with Bortezomib
    Authors:
    Robak P, Jarych D, Mikulski D, Dróżdż I, Węgłowska E, Kotkowska A, Misiewicz M, Smolewski P, Stawiski K, Fendler W, Szemraj J, Robak T
    Academic press:
    Cancers (rok: 2021, tom: 13(5), strony: 951-968), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13050951 - link to the publication
  2. Pretreatment Serum Levels of IL-1 Receptor Antagonist and IL-4 Are Predictors of Overall Survival in Multiple Myeloma Patients Treated with Bortezomib
    Authors:
    Mikulski D, Robak P, Perdas E, Węgłowska E, Łosiewicz A, Dróżdż I, Jarych D, Misiewicz M, Szemraj J, Fendler W, Robak T
    Academic press:
    J Clin Med (rok: 2021, tom: 11(1), strony: 112-126), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm11010112 - link to the publication
  3. Cytokine and Chemokine Profile in Patients with Multiple Myeloma Treated with Bortezomib
    Authors:
    Paweł Robak, Edyta Węgłowska, Izabela Dróżdż, Damian Mikulski , Dariusz Jarych, Magdalena Ferlińska, Ewa Wawrzyniak, Małgorzata Misiewicz, Piotr Smolewski , Wojciech Fendler, Janusz Szemraj, and Tadeusz Robak
    Academic press:
    Mediators of Inflammation (rok: 2020, tom: 45449, strony: 1835836), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/1835836 - link to the publication
  4. Drug resistance in multiple myeloma.
    Authors:
    Robak P, Drozdz I, Szemraj J, Robak T.
    Academic press:
    Cancer Treat Rev (rok: 2018, tom: 70, strony: 199-208), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ctrv.2018.09.001 - link to the publication
  5. The Value of Serum MicroRNA Expression Signature in Predicting Refractoriness to Bortezomib-Based Therapy in Multiple Myeloma Patients
    Authors:
    Paweł Robak , Izabela Drozdz , Dariusz Jarych, Damian Mikulski, Edyta Wegłowska, Monika Siemieniuk-Rys, Małgorzata Misiewicz, Konrad Stawiski, Wojciech Fendler, Janusz Szemraj, Piotr Smolewski and Tadeusz Robak
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 45340), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12092569 - link to the publication
  6. Bortezomib for the treatment of hematologic malignancies: 15 years later
    Authors:
    Pawel Robak, Tadeusz Robak
    Academic press:
    Expert Opin Investig Drugs. (rok: 2019, tom: 19, strony: 73-92), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1007/s40268-019-0269-9 - link to the publication
  7. Prognostic Value of Resistance Proteins in Plasma Cells from Multiple Myeloma Patients Treated with Bortezomib-Based Regimens
    Authors:
    Robak P, Szemraj J, Mikulski D, Drozdz I, Juszczak K, Jarych D, Misiewicz M, Kościelny K, Fendler W, Robak T
    Academic press:
    J Clin Med (rok: 2021, tom: 10(21), strony: 5028-5040), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm10215028. - link to the publication
  1. Novel drugs for multiple myeloma
    Authors:
    Pawel Robak, Tadeusz Robak
    Book:
    Topics in Anti-Cancer Research (rok: 2019, tom: 8, strony: 15707), Wydawca: eurekaselect
    Status:
    Published

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