Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Inhibitors of serine proteases as regulators of dendritic cell function.

2011/02/A/NZ5/00337

Keywords:

psoriasis reumatoid arthritis neutrophil extracellular traps plasmacytoid dendritic cells SLPI anti-trypsin

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Cichy 

Number of co-investigators in the project: 14

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 655 900 PLN

Project start date (Y-m-d): 2012-04-30

Project end date (Y-m-d): 2017-12-30

Project duration:: 68 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Laser fioletowy (90 000 PLN)
  2. Wirówka laboratoryjna z chłodzeniem.
  3. Doposażenie mikroskopu fluorescencyjnego Nikon Eclipse: Dwa obiektywy 100x i 4x oraz program do dekonwolucji. (92 000 PLN)
  4. Zestaw pipet automatycznych.

Information in the final report

  • Publication in academic press/journals (9)
  1. Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation.
    Authors:
    Cassetta L, Bruderek K, Skrzeczynska-Moncznik J, et al.
    Academic press:
    Journal for ImmunoTherapy of Cancer (rok: 2020, tom: 8, strony: 45304), Wydawca: BMJ Journals
    Status:
    Published
    DOI:
    10.1136/jitc-2020-001223 - link to the publication
  2. Role of Myeloid Regulatory Cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in inflammatory and autoimmune diseases and transplantation
    Authors:
    Giada Amodio, Joanna Cichy, Patricia Conde, Gianluca Matteoli, Aurélie Moreau, Jordi Ochando, H. Barbaros Oral, Michaela Pekarova, Elizabeth J. Ryan, Johannes Roth, Yahya Sohrabi, Maria-Cristina Cuturi, Silvia Gregori
    Academic press:
    Cancer Immunology, Immunotherapy (rok: 2019, tom: 68(4), strony: 661-672), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00262-018-2264-3 - link to the publication
  3. Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis.
    Authors:
    Skrzeczynska-Moncznik J, Wlodarczyk A, Zabieglo K, Kapinska-Mrowiecka M, Marewicz E, Dubin A, Potempa J, Cichy J
    Academic press:
    J Immunol (rok: 2012, tom: 189, strony: 1611-1617), Wydawca: J Immunol
    Status:
    Published
    DOI:
    10.4049/jimmunol.1103293 - link to the publication
  4. Inhibitors of Serine Proteases in Regulating the Production and Function of Neutrophil Extracellular Traps.
    Authors:
    Majewski P, Majchrzak-Gorecka M, Grygier B, Skrzeczynska-Moncznik J, Osiecka O, Cichy J.
    Academic press:
    Frontiers in Immunology (rok: 2016, tom: 7;261, strony: 45301), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2016.00261 - link to the publication
  5. Differences in immunoreactivity for neutrophil elastase and its controlling inhibitor SLPI reveal heterogeneity among neutrophils in psoriasis.
    Authors:
    J. Skrzeczynska-Moncznik, K. Zabieglo, O. Osiecka, A. Morytko, P. Brzoza, L. Drozdz, M. Kapinska-Mrowiecka, B. Korkmaz, M. Pastuszczak, J. Koslaka-Wegiel, J. Musial, J. Cichy
    Academic press:
    Journal of Investigative Dermatology (rok: 2020, tom: 7, strony: 1371-1378), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jid.2019.12.015 - link to the publication
  6. Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response
    Authors:
    Majchrzak-Gorecka M, Majewski P, Grygier B, Murzyn K, Cichy J.
    Academic press:
    Cytokine and Growth Factor Reviews (rok: 2015, tom: S1359-6101(15), strony: 30017-4), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cytogfr.2015.12.001 - link to the publication
  7. The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps.
    Authors:
    Zabieglo K, Majewski P, Majchrzak-Gorecka M, Wlodarczyk A, Grygier B, Zegar A, Kapinska-Mrowiecka M, Naskalska A, Pyrc K, Dubin A, Wahl SM, Cichy J.
    Academic press:
    Journal of Leukocyte Biology (rok: 2015, tom: 98(1):, strony: 99-106), Wydawca: Society of Leukocyte Biology
    Status:
    Published
    DOI:
    10.1189/jlb.4AB1114-543R - link to the publication
  8. DNA structures decorated with cathepsin G/secretory leukocyte proteinase inhibitor stimulate IFNI production by plasmacytoid dendritic cells.
    Authors:
    Skrzeczynska-Moncznik J, Wlodarczyk A, Banas M, Kwitniewski M, Zabieglo K, Kapinska-Mrowiecka M, Dubin A, Cichy J.
    Academic press:
    Am J Clin Exp Immunol. 2013 (rok: 2013, tom: 2, strony: 186-194), Wydawca: AJCEI
    Status:
    Published
    DOI:
    brak - link to the publication
  9. Eosinophils Regulate Interferon Alpha Production in Plasmacytoid Dendritic Cells Stimulated with Components of Neutrophil Extracellular Traps.
    Authors:
    Skrzeczynska-Moncznik J, Zabieglo K, Bossowski JP, Osiecka O, Wlodarczyk A, Kapinska-Mrowiecka M, Kwitniewski M, Majewski P, Dubin A, Cichy J.
    Academic press:
    J Interferon Cytokine Res. (rok: 2017, tom: 37, strony: 119-128), Wydawca: Marry Ann Liebert Inc.
    Status:
    Published
    DOI:
    10.1089/jir.2016.0036 - link to the publication

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