Projects funded by the NCN
Optical and time-resolved spectroscopy for hypothesis veryfication of the conducting by mTS the reductive reaction with THF utilization as a cofactor and for description of the inhibition mechanism of the mTS activity by chosen inhibitors.
2017/25/N/NZ1/01535
Keywords:
thymidylate synthase reaction uncoupling mTHF THF dUMP FdUMP N-4OH-dCMP absorption spectroscopy emission spectroscopy time-resolved spectroscopy
Descriptors:
- NZ1_3: Biophysics
- NZ1_2: Biochemistry
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Uniwersytet Warszawski, Wydział Fizyki
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 13 - announced on 2017-03-15
Amount awarded: 58 320 PLN
Project start date (Y-m-d): 2018-03-05
Project end date (Y-m-d): 2019-09-04
Project duration:: 18 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- BEKO Chłodziarko-zamrażarka, RCNA406E40LZXR 711 (2 798 PLN)
Information in the final report
- Publication in academic press/journals (1)
- Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP.Authors:J. Sobich, M. Prokopowicz, P. Maj, P. Wilk, Z. Zieliński, T. Frączyk, W. Rode.Academic press:Archives of Biochemistry and Biophysics (rok: 2019, tom: 674, strony: 108106), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.abb.2019.108106 - link to the publication