Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

2012/07/N/ST5/00128

Keywords:

cathepsin C fluorescent peptides peptide nitriles

Descriptors:

  • ST5_16:
  • ST5_23:
  • NZ1_2: Biochemistry

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Monika Łęgowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 4 - announced on 2012-09-15

Amount awarded: 149 940 PLN

Project start date (Y-m-d): 2013-07-10

Project end date (Y-m-d): 2016-07-09

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wyparka próżniowa (15 000 PLN)
  2. Łaźnia ultradźwiękowa.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. Ultrasensitive internally quenched substrates of human cathepsin L
    Authors:
    Łęgowska Monika, Wysocka Magdalena, Burster Timo, Pikuła Michał, Rolka Krzysztof, Lesner Adam
    Academic press:
    Analytical Biochemistry (rok: 2014, tom: 466, strony: 30-37), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ab.2014.08.010 - link to the publication
  2. Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples.
    Authors:
    Łęgowska Monika, Hamon Yveline, Wojtysiak Anna, Grzywa Renata, Sieńczyk Marcin, Burster Timo, Korkmaz Brice, Lesner Adam
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2016, tom: 612, strony: 91-102), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.007 - link to the publication
  3. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases
    Authors:
    Hamon Yveline, Łęgowska Monika, Hervé Virginie, Dallet-Choisy Sandrine, Marchand-Adam Sylvain, Vanderlynden Lise, Demonte Michèle, Williams Rich, Scott Christopher J., Si-Tahar Mustapha, Heuzé-Vourc'h Nathalie, Lalmanach Gilles, Jenne Dieter E., Lesner Adam, Gauthier Francis, Korkmaz Brice
    Academic press:
    The Journal of Biological Chemistry (rok: 2016, tom: 291, strony: 8486-8499), Wydawca: The American Society for Biochemistry and Molecular Biology, Inc.
    Status:
    Published
    DOI:
    10.1074/jbc.M115.707109 - link to the publication
  1. Novel substrates of human cathepsin C
    Authors:
    Łęgowska Monika, Reszka Przemysław, Bednarski Patrick J, Rolka Krzysztof, Lesner Adam
    Conference:
    33rd European Peptide Symposium (rok: 2014, ), Wydawca: John Wiley and Sons, LTD
    Data:
    konferencja 31.08 - 05.09.2014
    Status:
    Published

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