Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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3D structure-based search for selective inhibitor of thymidylate synthase of nematodes, a potential drug in chemotherapy of diseases caused by parasitic nematodes

2011/01/B/NZ6/01781

Keywords:

Thymidylate synthase Trichinella spiralis Caenorhabditis elegans Protein crystallography

Descriptors:

  • NZ6_6: Parasitology
  • NZ1_9: Biotechnology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Rode 

Number of co-investigators in the project: 8

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 396 000 PLN

Project start date (Y-m-d): 2011-12-12

Project end date (Y-m-d): 2015-12-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop stereoskopowy (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (6)
  1. Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer.
    Authors:
    Wilk P, Jarmuła A, Ruman T, Banaszak K, Rypniewski W, Cieśla J, Dowierciał A, Rode W
    Academic press:
    Bioorg Chem (rok: 2014, tom: 52, strony: 44-49), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2013.11.003 - link to the publication
  2. Crystal structures of thymidylate synthase from nematodes, Trichinella spiralis and Caenorhabditis elegans, as a potential template for species-specific drug design.
    Authors:
    Dowierciał A, Wilk P, Rypniewski W, Frączyk T, Jarmuła A, Banaszak K, Dąbrowska M, Cieśla J, Rode W
    Academic press:
    Pteridines (rok: 2013, tom: 24, strony: 87-91), Wydawca: DeGruyter
    Status:
    Published
    DOI:
    10.1515/pterid-2013-0011 - link to the publication
  3. Uncommon and parallel developmental patterns of thymidylate synthase expression and localization in Trichinella spiralis and Caenorhabditis elegans.
    Authors:
    Dąbrowska M, Gołos B, Wałajtys-Rode E, Zieliński Z, Wińska P, Cieśla J, Moczoń T, Rode W
    Academic press:
    Pteridines (rok: 2013, tom: 24, strony: 121-125), Wydawca: DeGruyter
    Status:
    Published
    DOI:
    10.1515/pterid-2013-0009 - link to the publication
  4. Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N4-hydroxy-dCMP
    Authors:
    Ludwiczak J, Maj P, Wilk P, Frączyk T, Ruman T, Kierdaszuk B, Jarmułaa A, Rode W
    Academic press:
    Mol. BioSyst. (rok: 2016, tom: 12, strony: 1333-1341), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C6MB00026F - link to the publication
  5. Properties of phosphorylated thymidylate synthase
    Authors:
    Frączyk T, Ruman T, Wilk P, Palmowski P, Rogowska-Wrzesinska A, Cieśla J, Zieliński Z, Nizioł J, Jarmuła A, Maj P, Gołos B, Wińska P, Ostafil S, Wałajtys-Rode E, Shugar D, Rode W
    Academic press:
    Biochim Biophys Acta - Proteins Proteom (rok: 2015, tom: 1854, strony: 1922-1934), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbapap.2015.08.007 - link to the publication
  6. Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate.
    Authors:
    Dowierciał A, Jarmuła A, Wilk P, Rypniewski W, Kierdaszuk B, Rode W
    Academic press:
    Pteridines (rok: 2013, tom: 24, strony: 93-98), Wydawca: DeGruyter
    Status:
    Published
    DOI:
    10.1515/pterid-2013-0010 - link to the publication
  7. Immunofluorescent localization of thymidylate synthase in the development of Trichinella spiralis and Caenorhabditis elegans.
    Authors:
    Gołos B, Dąbrowska M, Wałajtys-Rode E, Zieliński Z, Wińska P, Cieśla J, Jagielska E, Moczoń T, Rode W
    Academic press:
    Mol. Biochem. Parasitol. (rok: 2012, tom: 183, strony: 63-69), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molbiopara.2012.02.002 - link to the publication
  1. Crystal structures of thymidylate synthase from nematodes, Trichinella spiralis and Caenorhabditis elegans, as a potential template for species-specific drug design.
    Authors:
    Wilk P, Dowierciał A, Rypniewski W, Frączyk T, Jarmuła A, Rode W
    Conference:
    15th International Symposium on Pteridines and Folates (rok: 2012, ), Wydawca: INT SOC PTERIDINOLOGY
    Data:
    konferencja 9-13 maja 2012
    Status:
    Published
  2. Unusual and parallel developmental patterns of thymidylate synthase expression and localization in Trichinella spiralis and Caenorhabditis elegans.
    Authors:
    Dąbrowska M, Gołos B, Wałajtys-Rode E, Zieliński Z, Wińska P, Cieśla J, Jagielska E, Moczoń T, Rode W
    Conference:
    15th International Symposium on Pteridines and Folates, Antalya (rok: 2012, ), Wydawca: INT SOC PTERIDINOLOGY
    Data:
    konferencja 9-13 maja 2012
    Status:
    Published
  3. Mechanism of thymidylate synthase-catalyzed reaction inhibition by N4-OH-dCMP in view of crystallographic studies
    Authors:
    Dowierciał A, Wilk P, Jarmuła A, Krawiec K, Rypniewski W, Kierdaszuk B, Rode W/Rode W
    Conference:
    9th International Conference of Anticancer Research (rok: 2014, ), Wydawca: International Institute of Anticancer Research
    Data:
    konferencja 6-10.10. 2014
    Status:
    Published
    DOI:
    link to the publication
  4. Crystal structure of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N10-methylenetetrahydrofolate()
    Authors:
    Dowierciał A, Wilk P, Jarmuła A, Rypniewski W, Kierdaszuk B, Rode W
    Conference:
    15th International Symposium on Pteridines and Folates, 2012, Antalya (rok: 2012, ), Wydawca: INT SOC PTERIDINOLOGY
    Data:
    konferencja 9-13 maja
    Status:
    Published
  5. Mechanism of slow-binding inhibition of thymidylate synthase-catalyzed reaction by N4-OH-dCMP in view of crystallographic studies.
    Authors:
    Anna Dowierciał, Piotr Wilk, Adam Jarmuła, Krzysztof Krawiec, Wojciech Rypniewski, Borys Kierdaszuk, Wojciech Rode
    Conference:
    Prof. David Shugar 100th Anniversary Conference: Challenges in molecular biology, biophysics, and biomedicine (rok: 2015, ), Wydawca: Instytut Biochemii i Biofizyki PAN
    Data:
    konferencja 17-19 września
    Status:
    Published
  6. SEARCHING FOR THE DIFFERENCES BETWEEN TRICHINELLA SPIRALIS AND MOUSE THYMIDYLATE SYNTHASES: A QUEST FOR SPECIES − SPECIFIC DRUGS
    Authors:
    A. Dowierciał, A. Jarmuła, W.R. Rypniewski, T. Frączyk1, P. Wilk and W. Rode
    Conference:
    ISSRNS 2012 (rok: 2012, ), Wydawca: Instytut Fizyki PAN
    Data:
    konferencja maj 2012
    Status:
    Published

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