Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of pharmacological activity of new, nonselective gamma-aminobutyric acid (GABA) transport inhibitors in some behavioral models and the application of artificial intelligence for analysis, classification and prediction of effective and toxic dose regimens.

2012/05/B/NZ7/02705

Keywords:

GABA re-uptake seizures anxiety depression pain memory,oxidative stress isolated organs support vector machine genetic algorithms

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Kinga Sałat 

Number of co-investigators in the project: 15

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 597 000 PLN

Project start date (Y-m-d): 2013-02-18

Project end date (Y-m-d): 2016-10-17

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Generator elektrowstrząsów wraz z elektrodami usznymi (38 000 PLN)
  2. Gorąca/zimna płytka - podstawa termostatowania.
  3. Uniesiony labirynt krzyżowy (9 000 PLN)
  4. Labirynt wodny Morrisa (82 500 PLN)
  5. Laptopy, myszy komputerowe.
  6. Kolumny do chromatografii HPLC (4 000 PLN)
  7. Komputer z oprogramowaniem (2 szt.) (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (24)
  1. Modeling analgesic drug interactions using support vector regression: A new approach to isobolographic analysis
    Authors:
    Sałat R, Sałat K
    Academic press:
    Journal of Pharmacological and Toxicological Methods (rok: 2015, tom: 71, strony: 95-102), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.vascn.2014.09.006 - link to the publication
  2. Synthesis, biological evaluation and molecular docking studies of novel quinuclidinone derivatives as potential antimicrobial and anticonvulsant agents
    Authors:
    Łączkowski KZ, Landowska K, Biernasiuk A, Sałat K, Furgała A, Plech T, Malm A
    Academic press:
    Medicinal Chemistry Research (rok: 2017, tom: 26, strony: 2088-2104), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00044-017-1904-z - link to the publication
  3. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice
    Authors:
    Sałat K, Filipek B
    Academic press:
    Journal of Zhejiang University Science B (rok: 2015, tom: 16(3), strony: 167-178), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1631/jzus.B1400189 - link to the publication
  4. Black-Box modeling of PIDs implemented in PLCs without structural information: A Support Vector Regression approach.
    Authors:
    Sałat R, Awtoniuk M.
    Academic press:
    Neural Computing and Applications (rok: 2015, tom: 26, strony: 723-734), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00521-014-1754-2 - link to the publication
  5. Blonowe transportery dla kwasu gamma-aminomaslowego (GABA) jako potencjalny cel terapeutyczny dla lekow stosowanych w chorobach osrodkowego ukladu nerwowego.
    Authors:
    Podkowa A, Podkowa K
    Academic press:
    Acta Mygenica (rok: 2015, tom: 7, strony: 46-52), Wydawca: KNSB Mygen
    Status:
    Published
  6. Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties
    Authors:
    Sałat K, Podkowa A, Malikowska N, Kern F, Pabel J, Wojcieszak E, Kulig K, Wanner KT, Strach B, Wyska E
    Academic press:
    Neuropharmacology (rok: 2017, tom: 113, strony: 331-342), Wydawca: Elsevier
    Status:
    Published
  7. Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures
    Authors:
    Laczkowski KZ, Salat K, Misiura K, Podkowa A, Malikowska N.
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2016, tom: 31(6), strony: 1576-1582), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/14756366.2016.1158172 - link to the publication
  8. The effect of GABA transporter 1 (GAT1) inhibitor, tiagabine, on scopolamine-induced memory impairments in mice
    Authors:
    Salat K, Podkowa, A, Mogilski S, Zareba P, Kulig K, Salat R, Malikowska N, Filipek B
    Academic press:
    Pharmacological Reports (rok: 2015, tom: 67(6), strony: 1155-1162), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.04.018 - link to the publication
  9. 2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.
    Authors:
    Kowalczyk P, Sałat K, Höfner GC, Guzior N, Filipek B, Wanner KT, Kulig K.
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2013, tom: 21(17), strony: 5154-5167), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2013.06.038 - link to the publication
  10. ANTIHYPERALGESIC ACTIVITY OF 3-[4-(3-TRIFLUOROMETHYLPHENYL)-PIPERAZIN-1-YL]-DIHYDROFURAN-2-ONE IN THE OXALIPLATIN-INDUCED COLD HYPERALGESIA IN MICE
    Authors:
    Sałąt K, Włoch M, Krokosz M, Więckowski K, Malawska B, Librowski T, Rak A, Raźny K, Gaweł M, Gdula-Argasińska J
    Academic press:
    Acta Biologica Cracoviensia Series Zoologia (rok: 2014, tom: 55/56, strony: 92-99), Wydawca: PAN
    Status:
    Published
  11. Anticonvulsant active inhibitor of GABA transporter subtype 1, tiagabine, with activity in mouse models of anxiety, pain and depression
    Authors:
    Sałat K, Podkowa A, Kowalczyk P, Kulig K, Dziubina A, Filipek B, Librowski T
    Academic press:
    Pharmacological Reports (rok: 2015, tom: 67, strony: 465-472), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2014.11.003 - link to the publication
  12. Effect of pregabalin on fear-based conditioned avoidance learning and spatial learning in a mouse model of scopolamine-induced amnesia
    Authors:
    Sałat K, Podkowa A, Malikowska N, Trajer J
    Academic press:
    Toxicology Mechanisms and Methods (rok: 2017, tom: 27(3), strony: 181-190), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15376516.2016.1273426 - link to the publication
  13. Synthesis, biological evaluation and structure activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides
    Authors:
    Kowalczyk P, Sałat K, Hoefner G, Mucha M, Rapacz A, Podkowa A, Filipek B, Wanner KT, Kulig K.
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2014, tom: 83, strony: 256-273), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2014.06.024 - link to the publication
  14. Evaluation of anxiolytic-like, anticonvulsant, antidepressant-like and antinociceptive properties of new 2-substituted 4-hydroxybutanamides with affinity for GABA transporters in mice.
    Authors:
    Sałat K, Kulig K, Gajda J, Więckowski K, Filipek B, Malawska B.
    Academic press:
    Pharmacology, Biochemistry and Behavior (rok: 2013, tom: 110, strony: 145-153), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2013.06.013 - link to the publication
  1. Badanie właściwości przeciwdrgawkowych N-benzyloamidowych pochodnych kwasu gamma-hydroksymasłowego u myszy.
    Authors:
    Podkowa A, Kowalczyk P, Sałat K, Kulig K, Filipek B.
    Conference:
    VIII Kopernikańskie Seminarium Doktoranckie, Chomiąża Szlachecka k/Żnina (rok: 2014, ), Wydawca: Uniwersytet Mikołaja Kopernika w Toruniu
    Data:
    konferencja 25-27.06.2014
    Status:
    Published
  2. Badanie właściwości przeciwdrgawkowych nowych N-benzyloamidowych pochodnych kwasu gamma-hydroksymasłowego.
    Authors:
    Podkowa A
    Conference:
    Konferencja Doktorantów Collegium Medicum UJ (rok: 2014, ), Wydawca: Zeszyty Naukowe Towarzystwa Doktorantów UJ
    Data:
    konferencja 29-30.05.2014
    Status:
    Published
  3. EFFECT OF PREGABALIN ON FEAR-MOTIVATED MEMORY AND SPATIAL LEARNING IN SCOPOLAMINE-INDUCED MEMORY IMPAIRED MICE
    Authors:
    Sałat K, Podkowa A, Malikowska N, Sałat R
    Conference:
    8th World Congress of the World Institute of Pain, Nowy Jork, USA (rok: 2016, ), Wydawca: Wiley
    Data:
    konferencja 20-23.05.2016
    Status:
    Published
  4. POTENT AND SELECTIVE GAMMA-AMINOBUTYRIC ACID TRANSPORTER SUBTYPE 1 INHIBITOR EVOKES SPATIAL MEMORY IMPAIRMENTS IN THE MORRIS WATER MAZE TASK IN MICE
    Authors:
    Sałat K, Podkowa A, Malikowska N, Kern F, Pabel J, Wojcieszak E, Kulig K, Wanner KT
    Conference:
    1st International Conference on Pharmaceutical and Medical Sciences, Poprad, Słowacja (rok: 2016, ), Wydawca: UMEA SHINODA-KURACEJO
    Data:
    konferencja 22-24.07.2016
    Status:
    Published
  5. Plasma membrane GABA transporters (mGAT1-mGAT4) as targets for novel biologically active compounds.
    Authors:
    Sałat K.
    Conference:
    Molecular and Physiological Aspects of Regulatory Processess of the Organism (rok: 2013, ), Wydawca: Abaton
    Data:
    konferencja 14-15.06.2013
    Status:
    Published
  6. TIAGABINE – GABA TRANSPORTER TYPE 1 INHIBITOR ATTENUATES TACTILE ALLODYNIA IN OXALIPLATIN-INDUCED NEUROPATHIC PAIN WITHOUT IMPAIRING COGNITION
    Authors:
    Sałat K, Podkowa A, Sałat R, Kulig K, Zaręba P
    Conference:
    8th Congress of the World Institute of Pain, Nowy Jork, USA (rok: 2016, ), Wydawca: Wiley
    Data:
    konferencja 20-23.05.2016
    Status:
    Published
  7. The comparison of the effects of inhibition of different gamma-aminobutyric acid transporter isoforms in mice
    Authors:
    Podkowa A, Sałat K, Malikowska N, Rapacz A, Zareba P, Kulig K, Wanner KT, Hoefner G
    Conference:
    12th Warsaw International Medical Congress (rok: 2016, ), Wydawca: Warszawski Uniwersytet Medyczny
    Data:
    konferencja 12-15.05.2016
    Status:
    Published
  8. Badanie aktywności przeciwbólowej inhibitorów wychwytu zwrotnego kwasu gamma-aminomasłowego w teście bólu indukowanego kapsaicyną u myszy.
    Authors:
    Podkowa A, Salat K, Rapacz A, Dziubina A, Furgala A, Zareba P, Kulig K, Filipek B.
    Conference:
    IX Kopernikańskie Seminarium Doktoranckie w Toruniu (rok: 2015, ), Wydawca: Uniwersytet im. Mikolaja Kopernika w Toruniu
    Data:
    konferencja 24-26.06.2015
    Status:
    Published
  9. Effect of a novel GABA re-uptake inhibitor on cognitive functions in Morris water maze and radial-arm water maze in mice.
    Authors:
    Podkowa A, Salat K, Mogilski S, Mureddu V, Malikowska N, Zareba P, Kulig K, Filipek B.
    Conference:
    XXIV International Symposium: Molecular and Physiological Aspects of Regulatory Processes of the Organism. (rok: 2015, ), Wydawca: Joseph Dietl Malopolska Higher School in Cracow
    Data:
    konferencja 25.09.2015
    Status:
    Published
  10. GABA transporters as targets for the antidepressant-like action
    Authors:
    Podkowa A, Sałat K, Malikowska N, Dziubina A, Micallef D, Zareba P, Kulig K
    Conference:
    Neuronus 2016 IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronusforum
    Data:
    konferencja 22-24.04.2016
    Status:
    Published
  11. Novel gamma-aminobutyric acid reuptake inhibitor improves spatial learning and memory in Morris water maze and radial-arm water maze tests.
    Authors:
    Podkowa A, Salat K, Furgala A, Mogilski S, Zareba P, Kulig K, Filipek B.
    Conference:
    XIX International Congress of the Polish Pharmacological Society (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 17-19.09.2015
    Status:
    Published
  12. The comparison of the effects of donepezil and rivastigmine on memory and learning abilities using Morris water maze and two-day radial-arm water maze in mice.
    Authors:
    Podkowa A, Salat K, Wieckowska A, Malawska B, Mogilski S, Ziora A, Malikowska N, Furgala A, Filipek B.
    Conference:
    Neuronus IBRO & IRUN Neuroscience Forum (rok: 2015, ), Wydawca: Neuronusforum
    Data:
    konferencja 17-19.04.2015
    Status:
    Published
  13. Evaluation of anxiolytic-like properties of new GABA reuptake inhibitors.
    Authors:
    Podkowa A, Sałat K, Rapacz A.
    Conference:
    Neuronus 2014 IBRO & IRUN Neuroscience Forum (rok: 2014, ), Wydawca: Neuronusforum
    Data:
    konferencja 25-27.04.2014
    Status:
    Published
  14. GABA reuptake inhibitors attenuate anxiety and obsessive-compulsive behavior in the mouse marble-burying test
    Authors:
    Podkowa A, Sałat K, Malikowska N, Zareba P, Kulig K, Kern F, Pabel J, Wanner KT
    Conference:
    XXV International Symposium 'Molecular and Physiological Aspects of Regulatory Processes of the Organisms' (rok: 2016, ), Wydawca: Joseph Dietl Malopolska Higher School in Cracow
    Data:
    konferencja 24.09.2016
    Status:
    Published
  15. ROLA HAMOWANIA TRANSPORTERÓW KWASU GAMMA-AMINOMASŁOWEGO W AKTYWNOŚCI PRZECIWBÓLOWEJ I PRZECIWDRGAWKOWEJ U MYSZY
    Authors:
    Podkowa A, Sałat K, Rapacz A, Malikowska N, Zareba P, Kulig K, Filipek B
    Conference:
    VI Konferencja Doktorantów Uniwersytetu Jagiellońskiego - Collegium Medicum (rok: 2016, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 23.04.2016
    Status:
    Published
  16. Antiallodynic and antihyperalgesic activities of a novel, highly potent GABA transporter isoform 1 (GAT1) inhibitor in two mouse models of neuropathic pain
    Authors:
    Sałat K, Rojek A, Wojcieszak E, Sałat R, Podkowa A, Kern F, Pabel J, Wanner KT, Kulig K
    Conference:
    4th Annual International Conference on Pharmacology and Pharmaceutical Sciences (PHARMA 2016) (rok: 2016, ), Wydawca: Global Science and Technology Forum
    Data:
    konferencja 26-27.09.2016
    Status:
    Published
  17. Anticonvulsant activity of a novel gamma-aminobutyric acid transporter subtype 1 inhibitor in mice
    Authors:
    Podkowa A, Sałat K, Malikowska N, Kern F, Pabel J, Kulig K, Wanner KT, Wojcieszak E, Furgała A
    Conference:
    29th European Congress of Neuropsychopharmacology (rok: 2016, ), Wydawca: ECNP
    Data:
    konferencja 17-20.09.2016
    Status:
    Published
  18. Biological evaluation of novel inhibitors of plasma membrane GABA transporters in mice
    Authors:
    Sałat K, Podkowa A, Romanek K, Lechocka A, Szlonzak A, Kulig K, Kowalczyk P, Jakubowska A, Filipek B
    Conference:
    Molecular and Physiological Aspects of Regulatory Processess of the Organism (rok: 2013, ), Wydawca: Abaton
    Data:
    konferencja 14-15.06.2013
    Status:
    Published
  19. Discovery of novel anticonvulsant active GABA reuptake inhibitors.
    Authors:
    Salat K, Podkowa A, Rapacz A, Zareba P, Kulig K.
    Conference:
    Drug Discovery and Therapy World Congress 2015 (rok: 2015, ), Wydawca: Eureka Conferences, Inc.
    Data:
    konferencja 22-25.07.2015
    Status:
    Published
  20. Influence of a novel SLC6 family transporter inhibitor on scopolamine-induced memory impairments in mice.
    Authors:
    Podkowa A, Salat K, Mogilski S, Zareba P, Jakubowska A, Kulig K.
    Conference:
    10th Bialystok International Medical Congress for Young Scientists (rok: 2015, ), Wydawca: Students' Scientific Society of the Medical University of Białystok
    Data:
    konferencja 14-16.05.2015
    Status:
    Published
  21. Pharmacological activity of new N-benzylamide derivatives of gamma-aminobutyric acid and gamma-hydroxybutyric acid in mouse pain models
    Authors:
    Podkowa A, Sałat K, Kowalczyk P, Dziubina A, Kulig K, Filipek B.
    Conference:
    XXIII International Symposium 'Molecular and Physiological Aspects of Regulatory Processes of the Organisms' (rok: 2014, ), Wydawca: JKB Print
    Data:
    konferencja 26-27.09.2014
    Status:
    Published
  22. Plasma membrane GABA transporters - a target for biologically active derivatives of 4-aminobutanamides.
    Authors:
    Sałat K, Podkowa A, Rapacz A, Kowalczyk P, Kulig K, Filipek B.
    Conference:
    19th International Medical Esperanto Congress & 1st Central European Biomedical Congress, Budapest, Hungary (rok: 2014, ), Wydawca: ZOZ Ośrodek UMEA Shinoda-Kuracejo
    Data:
    konferencja 16-20.07.2014
    Status:
    Published
  23. Rola błonowych transporterów (mGAT1-4) dla kwasu gamma-aminomasłowego w aktywności przeciwlękowej i przeciwdepresyjnej u myszy.
    Authors:
    Podkowa A, Sałat K, Rapacz A, Kowalczyk P, Kulig K, Filipek B, Librowski T.
    Conference:
    XXVIII Ogólnopolskie Seminarium "Mechanizmy służące utrzymaniu życia i regulacji fizjologicznych" (rok: 2014, ), Wydawca: JKB Print
    Data:
    konferencja 14.06.2014
    Status:
    Published
  24. Solute carrier 6A1 (SLC6A1; GAT1) transporter subfamily as a target for novel memory-enhancing drugs.
    Authors:
    Salat K.
    Conference:
    Drug Discovery and Therapy World Congress 2015 (rok: 2015, ), Wydawca: Eureka Conferences, Inc.
    Data:
    konferencja 22-25.07.2015
    Status:
    Published