Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the presence of kinase CK2 inhibitors.

2015/17/B/ST5/00547

Keywords:

glutamate receptors antagonists willardiine derivatives anticancer agents,

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Warszawska, Wydział Chemiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bretner 

Number of co-investigators in the project: 14

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 963 000 PLN

Project start date (Y-m-d): 2016-01-26

Project end date (Y-m-d): 2020-01-25

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. waga analityczna.
  2. waga analityczna (5 800 PLN)
  3. zestawy komputerowe z drukarkami (3 szt.) (10 500 PLN)
  4. Spektrofotometr VIS Metertech SP-830plus.
  5. inkubator.
  6. polarymetr (48 000 PLN)
  7. wyparka (2 szt.) (52 000 PLN)
  8. Łażnia ultradźwiękowa (5 500 PLN)
  9. pH-metr (3 800 PLN)
  10. wytrząsarka do płytek wielodołkowych (6 000 PLN)
  11. Aparat do transferu.
  12. autoklaw stołowy (7 000 PLN)
  13. kamera do mikroskopu Olimpus z odwróconym polem, z komputerem i oprogramowaniem (21 000 PLN)
  14. rotor do wirówki Sorwal (21 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Formylation of a metathesis-derived ansa[4]- ferrocene: a simple route to anticancer organometallics†
    Authors:
    Maria Mazur,Michał Mrozowicz, Włodzimierz Buchowicz, Mariola Koszytkowska- Stawińska, Radosław Kamiński,[Zbigniew Ochal, Patrycja Wińska, Maria Bretner
    Academic press:
    Dalton Trans (rok: 2020, tom: 49, strony: 11504-11511), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0dt01975e - link to the publication
  2. Potential bioisosteres of β-uracilalanines derived from 1H-1,2,3-triazole-Ccarboxylic acids
    Authors:
    E.Mironiuk-Puchalska, W.Buchowicz, P.Grześkowiak, P.Wińska, M.Wielechowska, O.Karatsai, M.J.Rędowicz, M.Bretner, M.Koszytkowska-Stawińska
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: 83, strony: 500-510), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.061 - link to the publication
  3. New insight into nucleo α-amino acids - synthesis and SAR studies on antitumor activity of 􀀀-pyrimidine alanines
    Authors:
    J.Ignatowska, E.Mironiuk-Puchalska, P. Grzeskowiak, P. Wińska, M. Wielechowska, M. Bretner, O.Karatsai, M.J.Redowicz, M. Koszytkowska-Stawińska
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 100, strony: 103864-), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103864 - link to the publication
  4. Supramolecular Interactions between β‑Cyclodextrin and the Nucleobase Derivatives of Ferrocene
    Authors:
    A.Kasprzak, M.Koszytkowska-Stawińska, A.M. Nowicka, W.Buchowicz, M. Poplawska
    Academic press:
    The Journal of Organic Chemistry (rok: 2019, tom: 84, strony: 15900 - 15914), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.9b02353 - link to the publication
  5. Ferrocene Amino Acid Ester Uracil Conjugates: Synthesis, Structure, Electrochemistry and Antimicrobial Evaluation
    Authors:
    M.Daniluk, W. Buchowicz, M.Koszytkowska-Stawińska, K.Jarząbek, K.N.Jarzembska, R.Kamiński, M. Piszcz, A.E. Laudy, S.Tyski
    Academic press:
    ChemistrySelect (rok: 2019, tom: 4, strony: 11130 - 11135), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/slct.201902518 - link to the publication

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