Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the presence of kinase CK2 inhibitors.

2015/17/B/ST5/00547

Keywords:

glutamate receptors antagonists willardiine derivatives anticancer agents,

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Warszawska, Wydział Chemiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bretner 

Number of co-investigators in the project: 14

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 963 000 PLN

Project start date (Y-m-d): 2016-01-26

Project end date (Y-m-d): 2020-01-25

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometr VIS Metertech SP-830plus.
  2. pH-metr (3 800 PLN)
  3. polarymetr (48 000 PLN)
  4. waga analityczna (5 800 PLN)
  5. wytrząsarka do płytek wielodołkowych (6 000 PLN)
  6. Aparat do transferu.
  7. kamera do mikroskopu Olimpus z odwróconym polem, z komputerem i oprogramowaniem (21 000 PLN)
  8. rotor do wirówki Sorwal (21 000 PLN)
  9. wyparka (2 szt.) (52 000 PLN)
  10. zestawy komputerowe z drukarkami (3 szt.) (10 500 PLN)
  11. waga analityczna.
  12. Łażnia ultradźwiękowa (5 500 PLN)
  13. autoklaw stołowy (7 000 PLN)
  14. inkubator.

Information in the final report

  • Publication in academic press/journals (5)
  1. New insight into nucleo α-amino acids - synthesis and SAR studies on antitumor activity of 􀀀-pyrimidine alanines
    Authors:
    J.Ignatowska, E.Mironiuk-Puchalska, P. Grzeskowiak, P. Wińska, M. Wielechowska, M. Bretner, O.Karatsai, M.J.Redowicz, M. Koszytkowska-Stawińska
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 100, strony: 103864-), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103864 - link to the publication
  2. Potential bioisosteres of β-uracilalanines derived from 1H-1,2,3-triazole-Ccarboxylic acids
    Authors:
    E.Mironiuk-Puchalska, W.Buchowicz, P.Grześkowiak, P.Wińska, M.Wielechowska, O.Karatsai, M.J.Rędowicz, M.Bretner, M.Koszytkowska-Stawińska
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: 83, strony: 500-510), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.061 - link to the publication
  3. Ferrocene Amino Acid Ester Uracil Conjugates: Synthesis, Structure, Electrochemistry and Antimicrobial Evaluation
    Authors:
    M.Daniluk, W. Buchowicz, M.Koszytkowska-Stawińska, K.Jarząbek, K.N.Jarzembska, R.Kamiński, M. Piszcz, A.E. Laudy, S.Tyski
    Academic press:
    ChemistrySelect (rok: 2019, tom: 4, strony: 11130 - 11135), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/slct.201902518 - link to the publication
  4. Formylation of a metathesis-derived ansa[4]- ferrocene: a simple route to anticancer organometallics†
    Authors:
    Maria Mazur,Michał Mrozowicz, Włodzimierz Buchowicz, Mariola Koszytkowska- Stawińska, Radosław Kamiński,[Zbigniew Ochal, Patrycja Wińska, Maria Bretner
    Academic press:
    Dalton Trans (rok: 2020, tom: 49, strony: 11504-11511), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0dt01975e - link to the publication
  5. Supramolecular Interactions between β‑Cyclodextrin and the Nucleobase Derivatives of Ferrocene
    Authors:
    A.Kasprzak, M.Koszytkowska-Stawińska, A.M. Nowicka, W.Buchowicz, M. Poplawska
    Academic press:
    The Journal of Organic Chemistry (rok: 2019, tom: 84, strony: 15900 - 15914), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.9b02353 - link to the publication

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