Projects funded by the NCN

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Information of the project and the call

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Evaluation of SLC22A5 activity modulation in sensitizing glioma cells to the suppression of fatty acid oxidation by CPT1 inhibitors.

2016/23/N/NZ3/02430

Keywords:

glioma fatty acid oxidation SLC22A5 CPT1 carnitine anticancer drugs

Descriptors:

  • NZ3_6: Cell neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Barbara Juraszek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2017-07-12

Project end date (Y-m-d): 2019-12-11

Project duration:: 29 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. SLC22A5 (OCTN2) Carnitine Transporter-Indispensable for Cell Metabolism, a Jekyll and Hyde of Human Cancer.
    Authors:
    Barbara Juraszek, Katarzyna A Nałęcz
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 45314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25010014 - link to the publication
  2. Glioma cells survival depends both on fatty acid oxidation and on functional carnitine transport by SLC22A5
    Authors:
    Barbara Juraszek, Joanna Czarnecka‐Herok, Katarzyna A. Nałęcz
    Academic press:
    Journal of Neurochemistry (rok: 2021, tom: Vol156, Issue 5, strony: 642-657), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/jnc.15124 - link to the publication
  1. PO-227 Sensitising glioma cells to fatty acid oxidation inhibitor by modulation of SLC22A5 transporter activity.
    Authors:
    Barbara Juraszek, Katarzyna A. Nałęcz
    Conference:
    25th Biennial Congress of the European Association for Cancer Research (rok: 2018, ), Wydawca: ESMO Open 2018
    Data:
    konferencja 30 czerwca - 3 lipca
    Status:
    Published
    DOI:
    link to the publication
  2. Sensitizing glioma cells to fatty acid oxidation inhibitor by inhibition of SLC22A5 transporter activity.
    Authors:
    Barbara Juraszek, Joanna Czarnecka, Katarzyna A. Nałęcz
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS OPEN BIO
    Data:
    konferencja 6-11 lipca
    Status:
    Published
  3. Sensitizing glioma cells to fatty acid oxidation inhibitor by modulation of SLC22A5 carnitine transporter activity.
    Authors:
    Barbara Juraszek, Joanna Czarnecka, Katarzyna A. Nałęcz
    Conference:
    EMBO Workshop: Cellular Signalling and Cancer Therapy (rok: 2018, ), Wydawca: EMBO
    Data:
    konferencja 14-18 września
    Status:
    Published

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