Projects funded by the NCN
Development of HTS method based on fluorescently labelled guanosine analogues: novel route for RNA (guanosine-N7)-methyltransferase (N7MTase) activity studies and inhibitors searching
2016/23/N/ST4/03169
Keywords:
nucleotide cap methylation fluorescence molecular probes
Descriptors:
- ST4_3: Molecular architecture and structure
- ST4_13: Solid-state chemistry, surface physicochemistry
- NZ1_3: Biophysics
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 12 - announced on 2016-09-15
Amount awarded: 150 000 PLN
Project start date (Y-m-d): 2017-11-07
Project end date (Y-m-d): 2020-11-06
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Development of HTS method based on fluorescently labelled guanosine analogues: novel route for RNA (guanosine-N7)-methyltransferase (N7MTase) activity studies and inhibitors searching
2016/23/N/ST4/03169
Keywords:
nucleotide cap methylation fluorescence molecular probes
Descriptors:
- ST4_3: Molecular architecture and structure
- ST4_13: Solid-state chemistry, surface physicochemistry
- NZ1_3: Biophysics
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 12 - announced on 2016-09-15
Amount awarded: 150 000 PLN
Project start date (Y-m-d): 2017-11-07
Project end date (Y-m-d): 2020-11-06
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Jednopozycyjny uchwyt do kuwet do spektrofluorymetry Cary Eclipse termostatowany systemem Peltier (22 800 PLN)
Information in the final report
- Publication in academic press/journals (1)
- Articles in post-conference publications (2)
- Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase ActivityAuthors:Renata Kasprzyk; Mateusz Fido; Adam Mamot; Przemyslaw Wanat; Miroslaw Smietanski; Michal Kopcial; Victoria Cowling; Joanna Kowalska; Jacek JemielityAcademic press:Chemistry - A European Journal (rok: 2020, tom: 26, strony: 11266-11275), Wydawca: WileyStatus:PublishedDOI:10.1002/chem.202001036 - link to the publication
- Rozwój metod wysokoprzepustowych do badań białek oddziałujących z kapem w oparciu o fluorescencyjne sondy nukleotydoweAuthors:Kasprzyk R., Starek B.J., Kubacka D., Walczak S., Kowalska J., Jemielity J.Conference:61 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2018, ), Wydawca: Polskie Towarzystwo ChemiczneData:konferencja 17-21.09.2018Status:Published
- Tlenek grafenu jako wygaszacz w opracowywanej metodzie HTS do badań nad białkami oddziałującymi z końcem 5'-mRNAAuthors:Starek B.J., Kasprzyk R., Kowalska J., Jemielity J.Conference:61 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2018, ), Wydawca: Polskie Towarzystwo ChemiczneData:konferencja 17-21.09.2018Status:Published