Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome inhibitor-mediated cardiotoxicity

2017/25/B/NZ6/01139

Keywords:

aginase proteasome multiple myeloma cardiotoxicity immune response

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ4_4: Pathophysiology
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jakub Gołąb 

Number of co-investigators in the project: 6

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 952 100 PLN

Project start date (Y-m-d): 2018-01-24

Project end date (Y-m-d): 2022-07-23

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do echokardiografii myszy (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells
    Authors:
    Grzywa TM, Sosnowska A, Rydzynska Z, Lazniewski M, Plewczynski D, Klicka K, Malecka-Gieldowska M, Rodziewicz-Lurzynska A, Ciepiela O, Justyniarska M, Pomper P, Grzybowski MM, Blaszczyk R, Wegrzynowicz M, Tomaszewska A, Basak G, Golab J, Nowis D.
    Academic press:
    Communications Biology (rok: 2021, tom: 4, strony: 19), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s42003-021-02914-4 - link to the publication
  2. Myeloid Cell-Derived Arginase in Cancer Immune Response
    Authors:
    Full text links full text provider logo Actions Favorites Share Page navigation Title & authors Abstract Figures Similar articles Cited by References Publication types Related information LinkOut - more resources Review Front Immunol . 2020 May 15;11:938. doi: 10.3389/fimmu.2020.00938. eCollection 2020. Myeloid Cell-Derived Arginase in Cancer Immune Response Tomasz M Grzywa 1 , Anna Sosnowska 1 2 , Paweł Matryba 1 3 4 , Zuzanna Rydzynska 1 , Marcin Jasinski 1 , Dominika Nowis 1 5 6 , Jakub Golab 1 7
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 11, strony: 24), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.00938 - link to the publication
  3. Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity
    Authors:
    Kavita Ramji, Tomasz M. Grzywa, Anna Sosnowska, Aleksandra Paterek, Marta Okninska, Zofia Pilch, Joanna Barankiewicz, Filip Garbicz, Katarzyna Borg, Urszula Bany-Laszewicz, Abdesamad Zerrouqi, Beata Pyrzynska, Anna Rodziewicz-Lurzynska, Diana Papiernik, Piotr Sklepkiewicz, Hanna Kedzierska, Adam Staruch, Radoslaw Sadowski, Olga Ciepiela, Ewa Lech-Maranda, Przemyslaw Juszczynski, Urszula Mackiewicz, Michal Maczewski, Dominika Nowis, Jakub Golab
    Academic press:
    Scientific Reports , Wydawca: Springer Nature
    Status:
    Submitted
    DOI:
    brak - link to the publication

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