Determination of arginase-1 as a potential drug target in the treatment of multi

Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome inhibitor-mediated cardiotoxicity

2017/25/B/NZ6/01139

Keywords

Descriptors

NZ5_7: Leczenie chorób człowieka
NZ4_4: Patofizjologia ogólna
NZ6_1: Odporność swoista i nieswoista

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Jakub Adam Gołąb

Number of co-investigators in the project: 6

Call

OPUS 13 – announced on 2017-03-15

Amount awarded: 1 952 100 PLN
Project start date: 2018-01-24
Project end date: 2022-07-23
Project duration: 54 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

System do echokardiografii myszy. Cost: 200 000 PLN

Information in the final report

Publication in academic press/journals (2)

Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells

Authors:
Grzywa TM, Sosnowska A, Rydzynska Z, Lazniewski M, Plewczynski D, Klicka K, Malecka-Gieldowska M, Rodziewicz-Lurzynska A, Ciepiela O, Justyniarska M, Pomper P, Grzybowski MM, Blaszczyk R, Wegrzynowicz M, Tomaszewska A, Basak G, Golab J, Nowis D.

Academic press:
Communications Biology (year: 2021, volume: 4, pages: 19), Publisher: Nature Publishing Group

Status:
Published

DOI:
10.1038/s42003-021-02914-4 – link to the publication
Myeloid Cell-Derived Arginase in Cancer Immune Response

Authors:
Full text links full text provider logo Actions Favorites Share Page navigation Title & authors Abstract Figures Similar articles Cited by References Publication types Related information LinkOut - more resources Review Front Immunol . 2020 May 15;11:938. doi: 10.3389/fimmu.2020.00938. eCollection 2020. Myeloid Cell-Derived Arginase in Cancer Immune Response Tomasz M Grzywa 1 , Anna Sosnowska 1 2 , Paweł Matryba 1 3 4 , Zuzanna Rydzynska 1 , Marcin Jasinski 1 , Dominika Nowis 1 5 6 , Jakub Golab 1 7

Academic press:
Frontiers in Immunology (year: 2020, volume: 11, pages: 24), Publisher: Frontiers Media SA

Status:
Published

DOI:
10.3389/fimmu.2020.00938 – link to the publication

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