Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The alterations of lipid metabolism in colorectal cancer - their role in the development of disease and the asessment of antiproliferative action of lipid metabolism inhibitors

2016/22/E/NZ4/00665

Keywords:

colorectal cancer fatty acid phospholipid lipogenesis

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ4_11: Metabolism
  • ST4_6: Instrumental methods in chemistry

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Śledziński 

Number of co-investigators in the project: 6

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 596 586 PLN

Project start date (Y-m-d): 2017-05-18

Project end date (Y-m-d): 2021-11-17

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikroskop z cyfrowym aparatem fotograficznym (23 000 PLN)
  2. automatyczny licznik komórek.
  3. wirowka z chlodzeniem (25 000 PLN)
  4. zamrażarka niskotemperaturowa.
  5. cieplarka (6 500 PLN)
  6. komputer o specjalnych parametrach.
  7. wirówka (6 500 PLN)
  8. System aspiracji próżniowej (12 500 PLN)
  9. oprogramowanie SimLipid 5.10 (47 500 PLN)
  10. Inkubator do hodowli komórkowych z regulacją temperatury i stężenia dwutlenku węgla (53 500 PLN)
  11. Inkubator do hodowli komórek z regulacją temperatury, stężęnia dwutlenku węgla i stężenia tlenu.
  12. Komora laminarna z filtrem typu HEPA (49 000 PLN)

Information in the final report

  • Publication in academic press/journals (13)
  • Articles in post-conference publications (1)
  1. Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment
    Authors:
    JUDYTA ZABIELSKA, TOMASZ SLEDZINSKI and EWA STELMANSKA
    Academic press:
    Anticancer Research (rok: 2019, tom: 39, strony: 3385-3394), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13482 - link to the publication
  2. Inhibitors of fatty acid synthesis and oxidation as potential anticancer agents in colorectal cancer treatment
    Authors:
    Mozolewska Paulina, Duzowska Katarzyna, Pakiet Alicja, Mika Adriana, Śledziński Tomasz.
    Academic press:
    Anticancer Research (rok: 2020, tom: 40, strony: 4843-4856), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.14487 - link to the publication
  3. Preferential uptake of polyunsaturated fatty acids by colorectal cancer cells
    Authors:
    Adriana Mika, Jaroslaw Kobiela, Alicja Pakiet, Aleksandra Czumaj, Ewa Sokołowska, Wojciech Makarewicz, Michał Chmielewski, Piotr Stepnowski, Antonella Marino-Gamazza, Tomasz Sledzinski.
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 1954), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-58895-7. - link to the publication
  4. Alterations in complex lipids in tumor tissue of patients with colorectal cancer
    Authors:
    Pakiet Alicja, Sikora Kinga, Kobiela Jarek, Rostkowska Olga, Mika Adriana, Sledzinski Tomasz
    Academic press:
    Lipids in Health and Disease (rok: 2021, tom: 20, strony: ID 85), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12944-021-01512-x - link to the publication
  5. Biological role of unsaturated fatty acid desaturases in health and disease
    Authors:
    Czumaj Aleksandra, Śledziński Tomasz
    Academic press:
    Nutrients (rok: 2020, tom: 12, strony: 356), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu12020356 - link to the publication
  6. Methods of the analysis of oxylipins in biological samples
    Authors:
    Liakh Ivan, Pakiet Alicja, Śledziński Tomasz, Mika Adriana.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 349), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25020349 - link to the publication
  7. The pathophysiological role of CoA
    Authors:
    Aleksandra, Szrok-Jurga Sylwia, Hebanowska Areta, Turyn Jacek, Świerczyński Julian, Śledziński Tomasz, Stelmańska Ewa.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 9057), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239057 - link to the publication
  8. Changes in lipids composition and metabolism in colorectal cancer: a review
    Authors:
    Alicja Pakiet, Jarosław Kobiela, Piotr Stepnowski, Tomasz Sledzinski, Adriana Mika.
    Academic press:
    Lipids in Health and Disease (rok: 2019, tom: 18, strony: 21 (1-21)), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12944-019-0977-8 - link to the publication
  9. Rearrangements of blood and tissue fatty acid profile in colorectal cancer - molecular mechanism and diagnostic potential
    Authors:
    Adriana Mika, Katarzyna Duzowska, Lukasz P. Halinski, Alicja Pakiet, Aleksandra Czumaj, Olga Rostkowska, Malgorzata Dobrzycka, Jaroslaw Kobiela, Tomasz Sledzinski
    Academic press:
    Frontiers in Oncology (rok: 2021, tom: 11, strony: ID 689701), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2021.689701 - link to the publication
  10. Decreased Triacylglycerol Content and Elevated Contents of Cell Membrane Lipids in Colorectal Cancer Tissue: A Lipidomic Study
    Authors:
    Adriana Mika, Alicja Pakiet, Aleksandra Czumaj, Zbigniew Kaczynski, Ivan Liakh, Jarek Kobiela, Adrian Perdyan, Krystian Adrych, Wojciech Makarewicz and Tomasz Sledzinski
    Academic press:
    Journal of Clinical Medicine (rok: 2020, tom: 9, strony: 1095), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9041095 - link to the publication
  11. In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation
    Authors:
    ALEKSANDRA CZUMAJ, JUDYTA ZABIELSKA, ALICJA PAKIET, ADRIANA MIKA, OLGA ROSTKOWSKA, WOJCIECH MAKAREWICZ, JAROSŁAW KOBIELA, TOMASZ SLEDZINSKI and EWA STELMANSKA
    Academic press:
    Anticancer Research (rok: 2019, tom: 39, strony: 3815-3822), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13531 - link to the publication
  12. Inhibitors of Protein Tyrosine Phosphatase PTP1B With Anticancer Potential
    Authors:
    TOMASZ KOSTRZEWA, JOANNA STYSZKO, MAGDALENA GORSKA-PONIKOWSKA, TOMASZ SLEDZINSKI and ALICJA KUBAN-JANKOWSKA
    Academic press:
    Anticancer Research (rok: 2019, tom: 39, strony: 3379-3384), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13481 - link to the publication
  13. Modern Methods of Sample Preparation for the Analysis of Oxylipins in Biological Samples
    Authors:
    Ivan Liakh, Alicja Pakiet, Tomasz Sledzinski and Adriana Mika
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 1639), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24081639 - link to the publication
  1. Reprogramming of lipid metabolism in colorectal cancer cell
    Authors:
    Liakh Ivan, Mika Adriana.
    Conference:
    Ogólnopolska Konferencja Interdyscyplinarna "Eureka" (rok: 2020, ), Wydawca: Idea Knowledge Future
    Data:
    konferencja 9-10 styczeń 2020
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy