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The alterations of lipid metabolism in colorectal cancer - their role in the development of disease and the asessment of antiproliferative action of lipid metabolism inhibitors

2016/22/E/NZ4/00665

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ4_11: Metabolizm
  • ST4_6: Chemia analityczna

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Tomasz Śledziński

Number of co-investigators in the project: 6

Call

SONATA BIS 6 – announced on 2016-06-15

Amount awarded
1 596 586 PLN
Project start date
2017-05-18
Project end date
2021-11-17
Project duration
54 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator do hodowli komórek z regulacją temperatury, stężęnia dwutlenku węgla i stężenia tlenu.
  2. Inkubator do hodowli komórkowych z regulacją temperatury i stężenia dwutlenku węgla. Cost: 53 500 PLN
  3. Komora laminarna z filtrem typu HEPA. Cost: 49 000 PLN
  4. Mikroskop z cyfrowym aparatem fotograficznym. Cost: 23 000 PLN
  5. System aspiracji próżniowej. Cost: 12 500 PLN
  6. automatyczny licznik komórek.
  7. cieplarka. Cost: 6 500 PLN
  8. komputer o specjalnych parametrach.
  9. oprogramowanie SimLipid 5.10. Cost: 47 500 PLN
  10. wirowka z chlodzeniem. Cost: 25 000 PLN
  11. wirówka. Cost: 6 500 PLN
  12. zamrażarka niskotemperaturowa.

Information in the final report

Publication in academic press/journals (13)

  1. The pathophysiological role of CoA

    Authors:
    Aleksandra, Szrok-Jurga Sylwia, Hebanowska Areta, Turyn Jacek, Świerczyński Julian, Śledziński Tomasz, Stelmańska Ewa.
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 9057), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239057 – link to the publication

  2. Alterations in complex lipids in tumor tissue of patients with colorectal cancer

    Authors:
    Pakiet Alicja, Sikora Kinga, Kobiela Jarek, Rostkowska Olga, Mika Adriana, Sledzinski Tomasz
    Academic press:
    Lipids in Health and Disease (year: 2021, volume: 20, pages: ID 85), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s12944-021-01512-x – link to the publication

  3. Modern Methods of Sample Preparation for the Analysis of Oxylipins in Biological Samples

    Authors:
    Ivan Liakh, Alicja Pakiet, Tomasz Sledzinski and Adriana Mika
    Academic press:
    Molecules (year: 2019, volume: 24, pages: 1639), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24081639 – link to the publication

  4. Inhibitors of Protein Tyrosine Phosphatase PTP1B With Anticancer Potential

    Authors:
    TOMASZ KOSTRZEWA, JOANNA STYSZKO, MAGDALENA GORSKA-PONIKOWSKA, TOMASZ SLEDZINSKI and ALICJA KUBAN-JANKOWSKA
    Academic press:
    Anticancer Research (year: 2019, volume: 39, pages: 3379-3384), Publisher: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13481 – link to the publication

  5. Inhibitors of fatty acid synthesis and oxidation as potential anticancer agents in colorectal cancer treatment

    Authors:
    Mozolewska Paulina, Duzowska Katarzyna, Pakiet Alicja, Mika Adriana, Śledziński Tomasz.
    Academic press:
    Anticancer Research (year: 2020, volume: 40, pages: 4843-4856), Publisher: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.14487 – link to the publication

  6. Decreased Triacylglycerol Content and Elevated Contents of Cell Membrane Lipids in Colorectal Cancer Tissue: A Lipidomic Study

    Authors:
    Adriana Mika, Alicja Pakiet, Aleksandra Czumaj, Zbigniew Kaczynski, Ivan Liakh, Jarek Kobiela, Adrian Perdyan, Krystian Adrych, Wojciech Makarewicz and Tomasz Sledzinski
    Academic press:
    Journal of Clinical Medicine (year: 2020, volume: 9, pages: 1095), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9041095 – link to the publication

  7. Rearrangements of blood and tissue fatty acid profile in colorectal cancer - molecular mechanism and diagnostic potential

    Authors:
    Adriana Mika, Katarzyna Duzowska, Lukasz P. Halinski, Alicja Pakiet, Aleksandra Czumaj, Olga Rostkowska, Malgorzata Dobrzycka, Jaroslaw Kobiela, Tomasz Sledzinski
    Academic press:
    Frontiers in Oncology (year: 2021, volume: 11, pages: ID 689701), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2021.689701 – link to the publication

  8. Methods of the analysis of oxylipins in biological samples

    Authors:
    Liakh Ivan, Pakiet Alicja, Śledziński Tomasz, Mika Adriana.
    Academic press:
    Molecules (year: 2020, volume: 25, pages: 349), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25020349 – link to the publication

  9. Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment

    Authors:
    JUDYTA ZABIELSKA, TOMASZ SLEDZINSKI and EWA STELMANSKA
    Academic press:
    Anticancer Research (year: 2019, volume: 39, pages: 3385-3394), Publisher: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13482 – link to the publication

  10. Biological role of unsaturated fatty acid desaturases in health and disease

    Authors:
    Czumaj Aleksandra, Śledziński Tomasz
    Academic press:
    Nutrients (year: 2020, volume: 12, pages: 356), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nu12020356 – link to the publication

  11. Preferential uptake of polyunsaturated fatty acids by colorectal cancer cells

    Authors:
    Adriana Mika, Jaroslaw Kobiela, Alicja Pakiet, Aleksandra Czumaj, Ewa Sokołowska, Wojciech Makarewicz, Michał Chmielewski, Piotr Stepnowski, Antonella Marino-Gamazza, Tomasz Sledzinski.
    Academic press:
    Scientific Reports (year: 2020, volume: 10, pages: 1954), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-58895-7. – link to the publication

  12. In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation

    Authors:
    ALEKSANDRA CZUMAJ, JUDYTA ZABIELSKA, ALICJA PAKIET, ADRIANA MIKA, OLGA ROSTKOWSKA, WOJCIECH MAKAREWICZ, JAROSŁAW KOBIELA, TOMASZ SLEDZINSKI and EWA STELMANSKA
    Academic press:
    Anticancer Research (year: 2019, volume: 39, pages: 3815-3822), Publisher: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13531 – link to the publication

  13. Changes in lipids composition and metabolism in colorectal cancer: a review

    Authors:
    Alicja Pakiet, Jarosław Kobiela, Piotr Stepnowski, Tomasz Sledzinski, Adriana Mika.
    Academic press:
    Lipids in Health and Disease (year: 2019, volume: 18, pages: 21 (1-21)), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s12944-019-0977-8 – link to the publication

Articles in post-conference publications (1)

  1. Reprogramming of lipid metabolism in colorectal cancer cell

    Authors:
    Liakh Ivan, Mika Adriana.
    Conference:
    Ogólnopolska Konferencja Interdyscyplinarna Eureka (year: 2020, pages: 88-96), Publisher: Idea Knowledge Future
    Date:
    conference 9-10 styczeń 2020
    Status:
    Published

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