Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The alterations of lipid metabolism in colorectal cancer - their role in the development of disease and the asessment of antiproliferative action of lipid metabolism inhibitors

2016/22/E/NZ4/00665

Keywords:

colorectal cancer fatty acid phospholipid lipogenesis

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ4_11: Metabolism
  • ST4_6: Instrumental methods in chemistry

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Śledziński 

Number of co-investigators in the project: 6

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 596 586 PLN

Project start date (Y-m-d): 2017-05-18

Project end date (Y-m-d): 2021-11-17

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator do hodowli komórkowych z regulacją temperatury i stężenia dwutlenku węgla (53 500 PLN)
  2. Inkubator do hodowli komórek z regulacją temperatury, stężęnia dwutlenku węgla i stężenia tlenu.
  3. Komora laminarna z filtrem typu HEPA (49 000 PLN)
  4. automatyczny licznik komórek.
  5. cieplarka (6 500 PLN)
  6. wirówka (6 500 PLN)
  7. Mikroskop z cyfrowym aparatem fotograficznym (23 000 PLN)
  8. System aspiracji próżniowej (12 500 PLN)
  9. komputer o specjalnych parametrach.
  10. oprogramowanie SimLipid 5.10 (47 500 PLN)
  11. wirowka z chlodzeniem (25 000 PLN)
  12. zamrażarka niskotemperaturowa.

Information in the final report

  • Publication in academic press/journals (13)
  • Articles in post-conference publications (1)
  1. Changes in lipids composition and metabolism in colorectal cancer: a review
    Authors:
    Alicja Pakiet, Jarosław Kobiela, Piotr Stepnowski, Tomasz Sledzinski, Adriana Mika.
    Academic press:
    Lipids in Health and Disease (rok: 2019, tom: 18, strony: 21 (1-21)), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12944-019-0977-8 - link to the publication
  2. Inhibitors of fatty acid synthesis and oxidation as potential anticancer agents in colorectal cancer treatment
    Authors:
    Mozolewska Paulina, Duzowska Katarzyna, Pakiet Alicja, Mika Adriana, Śledziński Tomasz.
    Academic press:
    Anticancer Research (rok: 2020, tom: 40, strony: 4843-4856), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.14487 - link to the publication
  3. The pathophysiological role of CoA
    Authors:
    Aleksandra, Szrok-Jurga Sylwia, Hebanowska Areta, Turyn Jacek, Świerczyński Julian, Śledziński Tomasz, Stelmańska Ewa.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 9057), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239057 - link to the publication
  4. Methods of the analysis of oxylipins in biological samples
    Authors:
    Liakh Ivan, Pakiet Alicja, Śledziński Tomasz, Mika Adriana.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 349), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25020349 - link to the publication
  5. Rearrangements of blood and tissue fatty acid profile in colorectal cancer - molecular mechanism and diagnostic potential
    Authors:
    Adriana Mika, Katarzyna Duzowska, Lukasz P. Halinski, Alicja Pakiet, Aleksandra Czumaj, Olga Rostkowska, Malgorzata Dobrzycka, Jaroslaw Kobiela, Tomasz Sledzinski
    Academic press:
    Frontiers in Oncology (rok: 2021, tom: 11, strony: ID 689701), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2021.689701 - link to the publication
  6. Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment
    Authors:
    JUDYTA ZABIELSKA, TOMASZ SLEDZINSKI and EWA STELMANSKA
    Academic press:
    Anticancer Research (rok: 2019, tom: 39, strony: 3385-3394), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13482 - link to the publication
  7. Alterations in complex lipids in tumor tissue of patients with colorectal cancer
    Authors:
    Pakiet Alicja, Sikora Kinga, Kobiela Jarek, Rostkowska Olga, Mika Adriana, Sledzinski Tomasz
    Academic press:
    Lipids in Health and Disease (rok: 2021, tom: 20, strony: ID 85), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12944-021-01512-x - link to the publication
  8. Decreased Triacylglycerol Content and Elevated Contents of Cell Membrane Lipids in Colorectal Cancer Tissue: A Lipidomic Study
    Authors:
    Adriana Mika, Alicja Pakiet, Aleksandra Czumaj, Zbigniew Kaczynski, Ivan Liakh, Jarek Kobiela, Adrian Perdyan, Krystian Adrych, Wojciech Makarewicz and Tomasz Sledzinski
    Academic press:
    Journal of Clinical Medicine (rok: 2020, tom: 9, strony: 1095), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9041095 - link to the publication
  9. In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation
    Authors:
    ALEKSANDRA CZUMAJ, JUDYTA ZABIELSKA, ALICJA PAKIET, ADRIANA MIKA, OLGA ROSTKOWSKA, WOJCIECH MAKAREWICZ, JAROSŁAW KOBIELA, TOMASZ SLEDZINSKI and EWA STELMANSKA
    Academic press:
    Anticancer Research (rok: 2019, tom: 39, strony: 3815-3822), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13531 - link to the publication
  10. Modern Methods of Sample Preparation for the Analysis of Oxylipins in Biological Samples
    Authors:
    Ivan Liakh, Alicja Pakiet, Tomasz Sledzinski and Adriana Mika
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 1639), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24081639 - link to the publication
  11. Preferential uptake of polyunsaturated fatty acids by colorectal cancer cells
    Authors:
    Adriana Mika, Jaroslaw Kobiela, Alicja Pakiet, Aleksandra Czumaj, Ewa Sokołowska, Wojciech Makarewicz, Michał Chmielewski, Piotr Stepnowski, Antonella Marino-Gamazza, Tomasz Sledzinski.
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 1954), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-58895-7. - link to the publication
  12. Biological role of unsaturated fatty acid desaturases in health and disease
    Authors:
    Czumaj Aleksandra, Śledziński Tomasz
    Academic press:
    Nutrients (rok: 2020, tom: 12, strony: 356), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu12020356 - link to the publication
  13. Inhibitors of Protein Tyrosine Phosphatase PTP1B With Anticancer Potential
    Authors:
    TOMASZ KOSTRZEWA, JOANNA STYSZKO, MAGDALENA GORSKA-PONIKOWSKA, TOMASZ SLEDZINSKI and ALICJA KUBAN-JANKOWSKA
    Academic press:
    Anticancer Research (rok: 2019, tom: 39, strony: 3379-3384), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.13481 - link to the publication
  1. Reprogramming of lipid metabolism in colorectal cancer cell
    Authors:
    Liakh Ivan, Mika Adriana.
    Conference:
    Ogólnopolska Konferencja Interdyscyplinarna "Eureka" (rok: 2020, ), Wydawca: Idea Knowledge Future
    Data:
    konferencja 9-10 styczeń 2020
    Status:
    Published

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