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Information on the principal investigator and host institution

Information of the project and the call

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Conjugates of prion protein with dendrimers as inhibitors of Abeta peptide amyloidogenesis and cytotoxicity of potential application in Alzheimer disease therapy

2013/10/M/NZ4/00311

Keywords:

Alzheimer disease Abeta peptide prion protein amyloidogenesis

Descriptors:

  • NZ1_2: Biochemistry
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Nieznański 

Number of co-investigators in the project: 8

Call: HARMONIA 5 - announced on 2013-06-14

Amount awarded: 662 000 PLN

Project start date (Y-m-d): 2014-05-19

Project end date (Y-m-d): 2018-05-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Identification of prion protein-derived peptides of potential use in Alzheimer's disease therapy
    Authors:
    Hanna Nieznanska, Magdalena Bandyszewska, Krystyna Surewicz, Tomasz Zajkowski, Witold K. Surewicz, Krzysztof Nieznanski
    Academic press:
    BBA - Molecular Basis of Disease (rok: 2018, tom: 1864, strony: 2143-2153), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2018.03.023. - link to the publication
  2. Soluble prion protein and its N-terminal fragment prevent impairment of synaptic plasticity by Aβ oligomers: Implications for novel therapeutic strategy in Alzheimer's disease.
    Authors:
    Scott-McKean J.J., Surewicz K., Choi J.K., Ruffin V.A., Salameh A.I., Nieznanski K., Costa A.C., Surewicz W.K.
    Academic press:
    Neurobiology of Disease (rok: 2016, tom: 91, strony: 124-131), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nbd.2016.03.001. - link to the publication
  1. Neuroprotective role of prion protein in Alzheimer's disease
    Authors:
    Magdalena Bandyszewska, Hanna Nieznanska, Krzysztof Nieznanski
    Conference:
    VII International Conference Aspects of Neuroscience (rok: 2017, ), Wydawca: Uniwersytet Warszawski
    Data:
    konferencja 24-26 listopada
    Status:
    Published
  2. Prion protein - the therapeutic strategy in Alzheimer's disease?
    Authors:
    Magdalena Bandyszewska, Hanna Nieznańska, Bartosz Niżyński, Krzysztof Nieznański
    Conference:
    Protein misfolding in disease - Toxic aggregation-prone proteins in aging and age-related diseases: from structure to pathology and spreading (rok: 2016, ), Wydawca: CNRS
    Data:
    konferencja 12-16.09.2016
    Status:
    Published

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