Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The influence of perinatal exposure to selective serotonin reuptake inhibitors on the structure and functions of mice dorsal raphe nucleus neurons

2017/27/B/NZ4/01527

Keywords:

whole-cell patch-clamp electrophysiology serotonergic system SSRI neuroplasticity

Descriptors:

  • NZ4_7:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Władysław Hess 

Number of co-investigators in the project: 4

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 416 000 PLN

Project start date (Y-m-d): 2018-07-31

Project end date (Y-m-d): 2024-01-30

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice
    Authors:
    Bartosz Bobula, Magdalena Kusek, Grzegorz Hess
    Academic press:
    Pharmacology, Biochemistry and Bahavior (rok: 2024, tom: 240, strony: 173779 (1 - 6)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2024.173779 - link to the publication
  2. Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice
    Authors:
    Bartosz Bobula, Joanna Bąk, Agnieszka Kania, Marcin Siwiec, Michał Kiełbinski, Krzysztof Tokarski, Agnieszka Pałucha-Poniewiera, Grzegorz Hess
    Academic press:
    Pharmacology, Biochemistry and Behavior (rok: 2024, tom: 244, strony: 173849 (1-15)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2024.173849 - link to the publication
  1. The excitability and reactivity of 5-HT1A receptors in dorsal raphe neurons of 5-HT7 receptor knock-out mice
    Authors:
    Agnieszka Kania, Marcin Siwiec, Grzegorz Hess
    Conference:
    12th Neuronus 2022 Neuroscience Forum (rok: 2022, ), Wydawca: Acta Neurobiologiae Experimentalis Vol. 82 Supplement
    Data:
    konferencja 15-17 października
    Status:
    Published
  2. 5-HT7 receptor increases excitability of inhibitory interneurons but not projection neurons in the mouse dorsal raphe nucleus
    Authors:
    Joanna Bąk, Bartosz Bobula, Marcin Siwiec, Grzegorz Hess
    Conference:
    Virtual FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: Federation of European Neuroscience Societies
    Data:
    konferencja 27 - 27 sierpnia
    Status:
    Published

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