Projects funded by the NCN
Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activity
2012/05/N/ST5/01145
Keywords:
meningococcal meningitis alanyl aminopeptidase transition state analogues phosphonic analogues of amino acids
Descriptors:
- ST5_16:
- ST5_23:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Politechnika Wrocławska, Wydział Chemiczny
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 3 - announced on 2012-03-15
Amount awarded: 49 985 PLN
Project start date (Y-m-d): 2013-03-15
Project end date (Y-m-d): 2014-03-14
Project duration:: 12 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- pompa olejowa (7 919 PLN)
- waga analityczna (5 239 PLN)
Information in the final report
- Publication in academic press/journals (1)
- A structural insight into the P1-S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.Authors:Ewelina Węglarz-Tomczak, Łukasz Berlicki, Małgorzata Pawełczak, Bogusław Nocek, Andrzej Joachimiak, Artur MuchaAcademic press:European Journal of Medicinal Chemistry (rok: 2016, tom: 117, strony: 187-196), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2016.04.018 - link to the publication