Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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COX-2 inhibitors and/or PPAR agonists-conjugated PAMAM G3 dendrimers targeted into cancer cells. Biological properties and localization in vitro.

2014/13/D/NZ3/02825

Keywords:

COX-2 PPAR gamma receptor folate modified PAMAM dendrimer cancer cells

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_14: Other related subjects

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łukasz Uram 

Number of co-investigators in the project: 3

Call: SONATA 7 - announced on 2014-03-17

Amount awarded: 547 350 PLN

Project start date (Y-m-d): 2015-01-23

Project end date (Y-m-d): 2019-01-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (14)
  1. Antitumor and anti-nematode activities of α-mangostin
    Authors:
    Joanna Markowicz, Łukasz Uram, Justyna Sobich, Laura Mangiardi, Piotr Maj, Wojciech Rode
    Academic press:
    European Journal of Pharmacology (rok: 2019, tom: 863, strony: 172678), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2019.172678 - link to the publication
  2. Cellular uptake of glucoheptoamidated poly(amidoamine) PAMAM G3 dendrimer with amide-conjugated biotin, a potential carrier of anticancer drugs
    Authors:
    Uram Łukasz, Szuster Magdalena, Filipowicz Aleksandra, Zaręba Magdalena, Wałajtys-Rode Elżbieta, Wołowiec Stanisław
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2016, tom: 25, strony: 706-713), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2016.11.047 - link to the publication
  3. Different patterns of nuclear and mitochondrial penetration by the G3 PAMAM dendrimer and its biotin–pyridoxal bioconjugate BC-PAMAM in normal and cancer cells in vitro
    Authors:
    Uram Ł., Szuster M., Filipowicz A., Gargasz K., Wołowiec S., Wałajtys-Rode E.
    Academic press:
    International Journal of Nanomedicine (rok: 2015, tom: 10, strony: 5647 - 5661), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S87307 - link to the publication
  4. Evaluation of the localization and biological effects of PAMAM G3 dendrimer-biotin/pyridoxal conjugate as HaCaT keratinocyte targeted nanocarrier
    Authors:
    Magdalena Szuster, Łukasz Stanisław Uram, Aleksandra Filipowicz-Rachwał, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
    Academic press:
    Acta Biochimica Polonica (rok: 2019, tom: 66/2, strony: 191-200), Wydawca: Polish Biochemical Sciety and the Committiee of Biochemistry and Biophysics Polish Academy of Science
    Status:
    Published
    DOI:
    10.18388/abp.2018_2767 - link to the publication
  5. Study of chemical, physico-mechanical and biological properties of 4, 4′-methylenebis (cyclohexyl isocyanate)-based polyurethane films
    Authors:
    Piotr Król, Łukasz Uram, Bożena Król, Kinga Pielichowska, Małgorzata Walczak
    Academic press:
    Materials Science and Engineering: C (rok: 2018, tom: 93, strony: 483-494), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.msec.2018.07.082 - link to the publication
  6. Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells
    Authors:
    Łukasz Uram, Aleksandra Filipowicz-Rachwał, Maria Misiorek, Aleksandra Winiarz, Elżbieta Wałajtys-Rode, Stanisław Wołowiec
    Academic press:
    Biomolecules (rok: 2019, tom: 45544, strony: 437), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom9090437 - link to the publication
  7. Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities
    Authors:
    Piotr Maj, Mattia Mori, Justyna Sobich, Joanna Markowicz, Łukasz Uram, Zbigniew Zieliński, Deborah Quaglio, Andrea Calcaterra, Ylenia Cau, Bruno Botta, Wojciech Rode
    Academic press:
    Molecules (rok: 2020, tom: 25/12, strony: 2894), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25122894 - link to the publication
  8. PAMAM Dendrimers Attached to Collagen via a Malondialdehyde Linker
    Authors:
    Magdalena Zaręba, Łukasz Uram, Agata Białońska, Monika Stompor, Stanisław Wołowiec
    Academic press:
    Chemistry Select (rok: 2017, tom: 2, strony: 8262–8269), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/slct.201700719 - link to the publication
  9. Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-L-Leucine and its cytotoxicity for normal and cancer human cell lines
    Authors:
    Łukasz Uram, Aleksandra Filipowicz, Maria Misiorek, Natalia Pieńkowska, Joanna Markowicz, Elżbieta Wałajtys-Rode, Stanisław Wołowiec
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2018, tom: 124, strony: 45300), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejps.2018.08.019 - link to the publication
  10. Celecoxib substituted biotinylated poly (amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent
    Authors:
    Łukasz Uram, Joanna Markowicz, Maria Misiorek, Aleksandra Filipowicz-Rachwał, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2020, tom: 152, strony: 105439), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejps.2020.105439 - link to the publication
  11. N(4)-[B-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan)methyl]-2′-deoxycytidine as a potential boron delivery agent with respect to glioblastoma
    Authors:
    Łukasz Uram, Joanna Nizioł, Piotr Maj, JustynaSobich, Wojciech Rode, Tomasz Ruman
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2017, tom: 95, strony: 749-755), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biopha.2017.08.134 - link to the publication
  12. The effect of G3 PAMAM dendrimer conjugated with B-group vitamins on cell morphology, motility and ATP level in normal and cancer cells
    Authors:
    Łukasz Uram, Magdalena Szuster, Maria Misiorek, Aleksandra Filipowicz, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2017, tom: 102, strony: 275-283), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2017.03.022 - link to the publication
  13. Mixed-generation PAMAM G3-G0 megamer as a drug delivery system for nimesulide: Antitumor activity of the conjugate against human squamous carcinoma and glioblastoma cells
    Authors:
    Magdalena Zaręba, Przemysław Sareło, Marta Kopaczyńska, Agata Białońska, Łukasz Uram, Małgorzata Walczak, David Aebisher, Stanisław Wołowiec
    Academic press:
    International journal of molecular sciences (rok: 2019, tom: 20, strony: 4998), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20204998 - link to the publication
  14. The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro
    Authors:
    Łukasz Uram, Maria Misiorek, Monika Pichla, Aleksandra Filipowicz-Rachwał, Joanna Markowicz, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 3801), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24203801 - link to the publication

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