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COX-2 inhibitors and/or PPAR agonists-conjugated PAMAM G3 dendrimers targeted into cancer cells. Biological properties and localization in vitro.

2014/13/D/NZ3/02825

Keywords

Descriptors

  • NZ3_1: Biologia komórki
  • NZ3_14: Inne zagadnienia pokrewne

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

Voivodeship: podkarpackie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Łukasz Stanisław Uram

Number of co-investigators in the project: 3

Call

SONATA 7 – announced on 2014-03-17

Amount awarded
547 350 PLN
Project start date
2015-01-23
Project end date
2019-01-22
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (14)

  1. Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

    Authors:
    Piotr Maj, Mattia Mori, Justyna Sobich, Joanna Markowicz, Łukasz Uram, Zbigniew Zieliński, Deborah Quaglio, Andrea Calcaterra, Ylenia Cau, Bruno Botta, Wojciech Rode
    Academic press:
    Molecules (year: 2020, volume: 25/12, pages: 2894), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25122894 – link to the publication

  2. Celecoxib substituted biotinylated poly (amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent

    Authors:
    Łukasz Uram, Joanna Markowicz, Maria Misiorek, Aleksandra Filipowicz-Rachwał, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
    Academic press:
    European Journal of Pharmaceutical Sciences (year: 2020, volume: 152, pages: 105439), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejps.2020.105439 – link to the publication

  3. Antitumor and anti-nematode activities of α-mangostin

    Authors:
    Joanna Markowicz, Łukasz Uram, Justyna Sobich, Laura Mangiardi, Piotr Maj, Wojciech Rode
    Academic press:
    European Journal of Pharmacology (year: 2019, volume: 863, pages: 172678), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2019.172678 – link to the publication

  4. Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-L-Leucine and its cytotoxicity for normal and cancer human cell lines

    Authors:
    Łukasz Uram, Aleksandra Filipowicz, Maria Misiorek, Natalia Pieńkowska, Joanna Markowicz, Elżbieta Wałajtys-Rode, Stanisław Wołowiec
    Academic press:
    European Journal of Pharmaceutical Sciences (year: 2018, volume: 124, pages: 46031), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejps.2018.08.019 – link to the publication

  5. Evaluation of the localization and biological effects of PAMAM G3 dendrimer-biotin/pyridoxal conjugate as HaCaT keratinocyte targeted nanocarrier

    Authors:
    Magdalena Szuster, Łukasz Stanisław Uram, Aleksandra Filipowicz-Rachwał, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
    Academic press:
    Acta Biochimica Polonica (year: 2019, volume: 66/2, pages: 191-200), Publisher: Polish Biochemical Sciety and the Committiee of Biochemistry and Biophysics Polish Academy of Science
    Status:
    Published
    DOI:
    10.18388/abp.2018_2767 – link to the publication

  6. The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro

    Authors:
    Łukasz Uram, Maria Misiorek, Monika Pichla, Aleksandra Filipowicz-Rachwał, Joanna Markowicz, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
    Academic press:
    Molecules (year: 2019, volume: 24, pages: 3801), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24203801 – link to the publication

  7. Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells

    Authors:
    Łukasz Uram, Aleksandra Filipowicz-Rachwał, Maria Misiorek, Aleksandra Winiarz, Elżbieta Wałajtys-Rode, Stanisław Wołowiec
    Academic press:
    Biomolecules (year: 2019, volume: 46274, pages: 437), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biom9090437 – link to the publication

  8. Study of chemical, physico-mechanical and biological properties of 4, 4′-methylenebis (cyclohexyl isocyanate)-based polyurethane films

    Authors:
    Piotr Król, Łukasz Uram, Bożena Król, Kinga Pielichowska, Małgorzata Walczak
    Academic press:
    Materials Science and Engineering: C (year: 2018, volume: 93, pages: 483-494), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.msec.2018.07.082 – link to the publication

  9. PAMAM Dendrimers Attached to Collagen via a Malondialdehyde Linker

    Authors:
    Magdalena Zaręba, Łukasz Uram, Agata Białońska, Monika Stompor, Stanisław Wołowiec
    Academic press:
    Chemistry Select (year: 2017, volume: 2, pages: 8262–8269), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/slct.201700719 – link to the publication

  10. The effect of G3 PAMAM dendrimer conjugated with B-group vitamins on cell morphology, motility and ATP level in normal and cancer cells

    Authors:
    Łukasz Uram, Magdalena Szuster, Maria Misiorek, Aleksandra Filipowicz, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
    Academic press:
    European Journal of Pharmaceutical Sciences (year: 2017, volume: 102, pages: 275-283), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2017.03.022 – link to the publication

  11. N(4)-[B-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan)methyl]-2′-deoxycytidine as a potential boron delivery agent with respect to glioblastoma

    Authors:
    Łukasz Uram, Joanna Nizioł, Piotr Maj, JustynaSobich, Wojciech Rode, Tomasz Ruman
    Academic press:
    Biomedicine & Pharmacotherapy (year: 2017, volume: 95, pages: 749-755), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biopha.2017.08.134 – link to the publication

  12. Different patterns of nuclear and mitochondrial penetration by the G3 PAMAM dendrimer and its biotin–pyridoxal bioconjugate BC-PAMAM in normal and cancer cells in vitro

    Authors:
    Uram Ł., Szuster M., Filipowicz A., Gargasz K., Wołowiec S., Wałajtys-Rode E.
    Academic press:
    International Journal of Nanomedicine (year: 2015, volume: 10, pages: 5647 - 5661), Publisher: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S87307 – link to the publication

  13. Mixed-generation PAMAM G3-G0 megamer as a drug delivery system for nimesulide: Antitumor activity of the conjugate against human squamous carcinoma and glioblastoma cells

    Authors:
    Magdalena Zaręba, Przemysław Sareło, Marta Kopaczyńska, Agata Białońska, Łukasz Uram, Małgorzata Walczak, David Aebisher, Stanisław Wołowiec
    Academic press:
    International journal of molecular sciences (year: 2019, volume: 20, pages: 4998), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20204998 – link to the publication

  14. Cellular uptake of glucoheptoamidated poly(amidoamine) PAMAM G3 dendrimer with amide-conjugated biotin, a potential carrier of anticancer drugs

    Authors:
    Uram Łukasz, Szuster Magdalena, Filipowicz Aleksandra, Zaręba Magdalena, Wałajtys-Rode Elżbieta, Wołowiec Stanisław
    Academic press:
    Bioorganic & Medicinal Chemistry (year: 2016, volume: 25, pages: 706-713), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2016.11.047 – link to the publication

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