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Studies of alkylation mechanism of DNA oligomers using new Top I inhibitors from camptothecin family by physical organic methods and bioassays in terms of application in targeted oncological chemotherapy

2017/27/B/ST4/00190

Keywords:

mechanism of targeted chemotherapy new camptothecin derivatives NMR MS X-Ray CD DNA alkylation bioassays in vitro

Descriptors:

  • ST4_3:
  • ST5_16:
  • NZ7_14:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Narodowy Instytut Leków

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Lech Jan Kozerski 

Number of co-investigators in the project: 6

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 066 484 PLN

Project start date (Y-m-d): 2018-10-31

Project end date (Y-m-d): 2023-09-29

Project duration:: 59 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. New camptothecin derivatives for generalized oncological chemotherapy:Synthesis, stereochemistry and biology
    Authors:
    B. Naumczuk, M. Górecki, K. Wiktorska, M. Urbanowicz, J. Sitkowski, K. Lubelska, M. Milczarek, E. Bednarek, W. Bocian, L. Kozerski
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2021, tom: 46, strony: 128146), Wydawca: Elcevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2021.128146 - link to the publication
  2. Insight on the Interaction betweenthe Camptothecin Derivatives and DNA oligomer Mimicking the Target of the Topo I Inhibitors
    Authors:
    W. Bocian, B. Naumczuk, M.Urbanowicz, J.Sitkowski, E. Bednarek, K. Wiktorka, A. POgorzelska, E. Wielgus, L. Kozerski
    Academic press:
    Molecules (rok: 2022, tom: n27, strony: 45678), Wydawca: MDPI
    Status:
    Published
    DOI:
    103390/molecules/27206946 - link to the publication
  3. Novel Nontoxic 5,9-Disubstituted SN38 Derivatives: Characterization of Their Pharmacological Properties and Interactions with DNA Oligomers
    Authors:
    Bednarek E., Bocian W., Urbanowicz M., Sitkowski J., Naumczuk B., Kozerski L.,
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 7471), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22158190 - link to the publication
  4. The Mode of SN38 Derivatives Interacting with Nicked DNA Mimics Biological Targeting of Topo I Poisons
    Authors:
    Bocian W., Naumczuk B., Urbanowicz M., Sitkowski J., Bierczyńska-Krzysik A., Bednarek E., Wiktorska K., Milczarek M., Kozerski L.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 7471), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22147471 - link to the publication
  5. Solvent-dependent regioselectivity of 2'-deoxyadenosine alkylation by 9-aminomethyl derivatives of SN38
    Authors:
    B. Naumczuk, W. Bocian, J. Sitkowski, R. Kawęcki, L. Kozerski
    Academic press:
    New Journal of Chemistry (rok: 2019, tom: 43, strony: 18975-18978), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9nj04828f - link to the publication
  6. A NMR study of binding the metabolite of SN38 derivatives to a model nicked DNA decamer mimicking target of Topo I inhibitors,
    Authors:
    B. Naumczuk, J. Sitkowski, W. Bocian, M. Urbanowicz (Stolarska), E. Bednarek, L. Kozerski
    Academic press:
    Bioorganic Chemistry (rok: 2021, tom: 107, strony: 104631'), Wydawca: Elsevier B.V., Amsterdam, Holandia,
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2021.104631 - link to the publication
  7. Regioselective alkylation reaction of the 2'-deoxycytidine with 9-aminomethyl derivatives of SN38
    Authors:
    Beata Naumczuk, Robert Kawęcki, Wojciech Bocian, Elżbieta Bednarek, Jerzy Sitkowski, Lech Kozerski
    Academic press:
    Journal of Molecular Structure (rok: 2019, tom: 1176, strony: 298-302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruct.2018.08.096 - link to the publication

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