Studies of alkylation mechanism of DNA oligomers using new Top I inhibitors from camptothecin family by physical organic methods and bioassays in terms of application in targeted oncological chemotherapy
2017/27/B/ST4/00190
Keywords
Descriptors
- ST4_3: Metody spektroskopowe i spektrometryczne
- ST5_16: Chemia biologiczna
- NZ7_14: Farmacja, farmakoterapia, farmakologia
Panel
ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution
Narodowy Instytut Leków
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 14 – announced on 2017-09-15
- Amount awarded
- 1 066 484 PLN
- Project start date
- 2018-10-31
- Project end date
- 2023-09-29
- Project duration
- 59 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (7)
-
The Mode of SN38 Derivatives Interacting with Nicked DNA Mimics Biological Targeting of Topo I Poisons
- Authors:
- Bocian W., Naumczuk B., Urbanowicz M., Sitkowski J., Bierczyńska-Krzysik A., Bednarek E., Wiktorska K., Milczarek M., Kozerski L.
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 7471), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22147471 – link to the publication
-
A NMR study of binding the metabolite of SN38 derivatives to a model nicked DNA decamer mimicking target of Topo I inhibitors,
- Authors:
- B. Naumczuk, J. Sitkowski, W. Bocian, M. Urbanowicz (Stolarska), E. Bednarek, L. Kozerski
- Academic press:
- Bioorganic Chemistry (year: 2021, volume: 107, pages: 104631'), Publisher: Elsevier B.V., Amsterdam, Holandia,
- Status:
- Published
- DOI:
- 10.1016/j.bioorg.2021.104631 – link to the publication
-
Novel Nontoxic 5,9-Disubstituted SN38 Derivatives: Characterization of Their Pharmacological Properties and Interactions with DNA Oligomers
- Authors:
- Bednarek E., Bocian W., Urbanowicz M., Sitkowski J., Naumczuk B., Kozerski L.,
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 7471), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22158190 – link to the publication
-
Solvent-dependent regioselectivity of 2'-deoxyadenosine alkylation by 9-aminomethyl derivatives of SN38
- Authors:
- B. Naumczuk, W. Bocian, J. Sitkowski, R. Kawęcki, L. Kozerski
- Academic press:
- New Journal of Chemistry (year: 2019, volume: 43, pages: 18975-18978), Publisher: Royal Society of Chemistry
- Status:
- Published
- DOI:
- 10.1039/c9nj04828f – link to the publication
-
Insight on the Interaction betweenthe Camptothecin Derivatives and DNA oligomer Mimicking the Target of the Topo I Inhibitors
- Authors:
- W. Bocian, B. Naumczuk, M.Urbanowicz, J.Sitkowski, E. Bednarek, K. Wiktorka, A. POgorzelska, E. Wielgus, L. Kozerski
- Academic press:
- Molecules (year: 2022, volume: n27, pages: 46043), Publisher: MDPI
- Status:
- Published
-
New camptothecin derivatives for generalized oncological chemotherapy:Synthesis, stereochemistry and biology
- Authors:
- B. Naumczuk, M. Górecki, K. Wiktorska, M. Urbanowicz, J. Sitkowski, K. Lubelska, M. Milczarek, E. Bednarek, W. Bocian, L. Kozerski
- Academic press:
- Bioorganic & Medicinal Chemistry Letters (year: 2021, volume: 46, pages: 128146), Publisher: Elcevier
- Status:
- Published
- DOI:
- 10.1016/j.bmcl.2021.128146 – link to the publication
-
Regioselective alkylation reaction of the 2'-deoxycytidine with 9-aminomethyl derivatives of SN38
- Authors:
- Beata Naumczuk, Robert Kawęcki, Wojciech Bocian, Elżbieta Bednarek, Jerzy Sitkowski, Lech Kozerski
- Academic press:
- Journal of Molecular Structure (year: 2019, volume: 1176, pages: 298-302), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.molstruct.2018.08.096 – link to the publication