Projects funded by the NCN
Effect of deimination of essential arginine residues on the function of protease inhibitors and other components of innate immunity system
2012/05/B/NZ6/00581
Keywords:
deimination citrullination inflammation peptidylarginine deiminase proteolysis PAR complement kinins coagulation clotting innate immunity
Descriptors:
- NZ1_2: Biochemistry
- NZ6_1: Adaptive and innate immunity
- NZ2_3: Proteomics
Panel:
NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution :
Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 3 - announced on 2012-03-15
Amount awarded: 419 998 PLN
Project start date (Y-m-d): 2013-02-21
Project end date (Y-m-d): 2016-02-20
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Komora do pracy z RNA/DNA (20 000 PLN)
- System filtracyjny do wody o jakości HPLC (25 000 PLN)
- Inkubator CO2.
- Zamrażarka -80C, "kompaktowa" (35 000 PLN)
- Koagulometr optyczny (14 995 PLN)
- Drobny sprzęt laboratoryjny (15 000 PLN)
Information in the final report
- Publication in academic press/journals (5)
- Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activityAuthors:Bielecka E, Scavenius C, Kantyka T, Jusko M, Mizgalska D, Szmigielski B, Potempa B, Enghild JJ, Prossnitz ER, Blom AM, Potempa JAcademic press:Journal of Biological Chemistry (rok: 2014, tom: 289(47), strony: 32481-7), Wydawca: American Society for Biochemistry and Molecular BiologyStatus:PublishedDOI:10.1074/jbc.C114.617142. - link to the publication
- Citrullination in the periodontium-a possible link between periodontitis and rheumatoid arthritisAuthors:Laugisch O, Wong A, Sroka A, Kantyka T, Koziel J, Neuhaus K, Sculean A, Venables PJ, Potempa J, Möller B, Eick S.Academic press:Clinical Oral investigations (rok: 2016, tom: 20(4), strony: 675-83), Wydawca: SpringerStatus:PublishedDOI:10.1007/s00784-015-1556-7 - link to the publication
- Gingipains of Porphyromonas gingivalis affect the stability and function of SPINK6, a tissue inhibitor of human kallikreinsAuthors:Karolina Plaza, Magdalena Kalinska, Oliwia Bochenska, Ulf Meyer-Hoffert, Zhihong Wu, Jan Fischer, Katherine Falkowski, Laura Sasiadek, Ewa Bielecka, Barbara Potempa, Andrzej Kozik, Jan Potempa and Tomasz KantykaAcademic press:Journal of Biological Chemistry (rok: 2016, tom: 2016 Jun 27, strony: pii: jbc.M116.722942. [Epub ahead of print]), Wydawca: American Society of Biological Chemists; Rockefeller Institute for Medical Research; American Society for Biochemistry and Molecular Biology, American Society for Biochemistry and Molecular BiologyStatus:PublishedDOI:10.1074/jbc.M116.722942 - link to the publication
- Kallikreins - The melting pot of activity and functionAuthors:Kalinska M, Meyer-Hoffert U, Kantyka T, Potempa JAcademic press:Biochimie (rok: 2016, tom: 122, strony: 270-82), Wydawca: Elsevier\Société Française de Biochimie et Biologie MoléculaireStatus:PublishedDOI:10.1016/j.biochi.2015.09.023 - link to the publication
- Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminaseAuthors:Goulas T, Mizgalska D, Garcia-Ferrer I, Kantyka T, Guevara T, Szmigielski B, Sroka A, Millán C, Usón I, Veillard F, Potempa B, Mydel P, Solà M, Potempa J, Gomis-Rüth FXAcademic press:Scientific Reports (rok: 2015, tom: 5, strony: 11969), Wydawca: NatureStatus:PublishedDOI:10.1038/srep11969 - link to the publication