Projects funded by the NCN
Design of new small molecular regulators (inhibitors, activators) of the catalytic activity of adenylate kinases. Molecular basis for the mechanism of the regulator action.
2017/25/B/ST4/00376
Keywords:
adenylate kinase statins substrate analogues X-ray structure SPR
Descriptors:
- ST4_4: Theoretical and computational chemistry
- NZ1_4: Structural biology
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Chemii
woj. kujawsko-pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 13 - announced on 2017-03-15
Amount awarded: 729 900 PLN
Project start date (Y-m-d): 2018-01-19
Project end date (Y-m-d): 2023-01-18
Project duration:: 60 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- HPLC system (210 000 PLN)
- Notebook Dell Latitude 3490.
- system chromatografii niskociśnieniowej - AKTA START.
- Spektrofotometr (30 000 PLN)
- Wytwornica lodu.
- Zamrażarka niskotemperaturowa (30 000 PLN)
Information in the final report
- Publication in academic press/journals (1)
- Assessing the Interactions of Statins with Human Adenylate Kinase Isoenzyme 1: Fluorescence and Enzyme Kinetic StudiesAuthors:M. Wujak, A. Kozakiewicz, A. Ciarkowska, J.I. Loch, M. Barwiołek, Z. Sokołowska, M. Budny, A. WojtczakAcademic press:International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 5541-5559), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms22115541 - link to the publication