Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New mulitple target-directed ligands - A1/A2A adenosine receptors antagonists and monoamine oxidase B inhibitors - searching for innovative therapeutic approaches for the neurodegenerative diseases

2016/23/N/NZ7/00475

Keywords:

adenosine receptors monoamine oxidase B Parkinson's disease neuroptotection

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Michał Załuski 

Number of co-investigators in the project: 3

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 96 200 PLN

Project start date (Y-m-d): 2017-10-02

Project end date (Y-m-d): 2020-04-01

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. sonda światłowodowa do syntetyzatora mikrofalowego CEM Discovery (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies
    Authors:
    Michał Załuski, Jakub Schabikowski, Miriam Schlenk, Agnieszka Olejarz-Maciej, Bartłomiej Kubas, Tadeusz Karcz, Kamil Kuder, Gniewomir Latacz, Małgorzata Zygmunt, David Synak, Sonja Hinz, Christa E. Müller, Katarzyna Kieć-Kononowicz
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2019, tom: 27, strony: 1195-1210), Wydawca: Elsevier Ltd
    Status:
    Published
    DOI:
    10.1016/j.bmc.2019.02.004. - link to the publication
  2. Novel, Dual Target‐Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B.
    Authors:
    Kuder, K.J., Załuski, M., Schabikowski, J., Latacz, G., Olejarz‐Maciej, A., Jaśko, P., Doroz‐Płonka, A., Brockmann, A., Müller, C.E. and Kieć‐Kononowicz, K.
    Academic press:
    ChemMedChem (rok: 2020, tom: 6, strony: 772-786), Wydawca: John Wiley & Sons, Inc.
    Status:
    Accepted for publication
    DOI:
    10.1002/cmdc.201900717 - link to the publication
  3. 8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation.
    Authors:
    Michał Załuski, Jakub Schabikowski, Piotr Jaśko, Adrian Bryła, Agnieszka Olejarz-Maciej, Maria Kaleta, Monika Głuch-Lutwin, Andreas Brockmann, Sonja Hinz, Małgorzata Zygmunt, Kamil Kuder, Gniewomir Latacz, Christin Vielmuth, Christa E. Müller, Katarzyna Kieć- Kononowicz
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 101, strony: brak), Wydawca: Elsevier Ltd
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.104033. - link to the publication

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