Projects funded by the NCN
New 1,3,4-thiadiazole derivatives as inhibitors of critical steps of the glutamine-glutamate cycle in glioblastoma cells.
2013/11/D/NZ7/00925
Keywords:
1,3,4-thiadiazole derivatives glioblastoma glutamine glutamate glutaminase
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: SONATA 6 - announced on 2013-09-16
Amount awarded: 435 500 PLN
Project start date (Y-m-d): 2014-07-10
Project end date (Y-m-d): 2018-01-09
Project duration:: 42 months (the same as in the proposal)
Project status: Project settled
Information in the final report
- Publication in academic press/journals (2)
- Downregulation of GLS2 in glioblastoma cells is related to DNA hypermethylation but not to the p53 status.Authors:Szeliga M, Bogacińska-Karaś M, Kuźmicz K, Rola R, Albrecht J.Academic press:Molecular Carcinogenesis (rok: 2016, tom: 55(9), strony: 1309-1316), Wydawca: Wiley Periodicals, Inc.Status:PublishedDOI:10.1002/mc.22372 - link to the publication
- Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway.Authors:Majewska E, Márquez J, Albrecht J, Szeliga M.Academic press:Cansers (Basel) (rok: 2019, tom: 11, strony: pii: E115), Wydawca: MDPIStatus:PublishedDOI:10.3390/cancers11010115. - link to the publication