Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Novel urease inhibitors as means to control ureolytic microbial pathogens

2011/03/B/NZ6/04964

Keywords:

urease virulence Helicobacter pylori Proteus mirabilis

Descriptors:

  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

POLITECHNIKA WROCŁAWSKA

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Grabowiecka 

Number of co-investigators in the project: 6

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 248 000 PLN

Project start date (Y-m-d): 2012-08-02

Project end date (Y-m-d): 2016-06-01

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Nablatowa komora klasy II z pionowym laminarnym przepływem oczyszczonego powietrza.
  2. Titrator z funkcją pH-stat. (35 000 PLN)
  3. Waga analityczna (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Bis(aminomethyl)phosphinic Acid, a Highly Promising Scaffold for the Development of Bacterial Urease Inhibitors
    Authors:
    Katarzyna Macegoniuk, Anna Dziełak, Artur Mucha, Łukasz Berlicki
    Academic press:
    ACS Medicinal Chemistry Letters (rok: 2015, tom: 6, strony: 146-150), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/ml500380f - link to the publication
  2. Interferences in the Optimization of the MTT Assay for Viability Estimation of Proteus mirabilis
    Authors:
    Ewa Grela, Adam Ząbek, Agnieszka Grabowiecka
    Academic press:
    Avicenna Journal of Medical Microbiology (rok: 2015, tom: 7(4), strony: 159-167), Wydawca: Avicenna Research Institute
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Aminophosphinic and aminophosphonic acids as highly effective inhibitors of Helicobacter pylori urease
    Authors:
    Katarzyna Macegoniuk Ewa Grela Monika Biernat Grazyna Gosciniak Anna Dzielak Artur Mucha Łukasz Berlicki Agnieszka Grabowiecka
    Academic press:
    PLOS ONE , Wydawca: PLOS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. 1,2-Benzisoselenazol-3(2H)-one derivatives as a new class of bacterial urease inhibitors
    Authors:
    Katarzyna Macegoniuk, Ewa Grela, Jerzy Palus, Ewa Rudzińska-Szostak, Agnieszka Grabowiecka, Monika Biernat, Łukasz Berlicki
    Academic press:
    Journal of Medicinal Chemistry (rok: 2016, tom: 59 (17), strony: 8125-8133), Wydawca: American Chemical Society (ACS)
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.6b00986 - link to the publication
  5. Whole-cell Proteus mirabilis urease inhibition by aminophosphinates for the control of struvite formation
    Authors:
    Ewa Grela, Anna Dziełak, Katarzyna Szydłowska, Artur Mucha, Paweł Kafarski, Agnieszka 5 Grabowiecka
    Academic press:
    Journal of Medical Microbiology , Wydawca: Microbiology Society Journals
    Status:
    Accepted for publication
    DOI:
    10.1099/jmm.0.000342 - link to the publication
  1. Proteus mirabilis as the example of ureolytic pathogen: Characteristics and methodology
    Authors:
    Ewa Grela
    Book:
    Na pograniczu chemii i biologii, ISBN 978-83-232-2803-5 (rok: 2014, tom: XXXIII, strony: 305-3011), Wydawca: Wydawnictwo Naukowe Uniwersytetu im. Adama Mickiewicza
    Status:
    Published

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