Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of neutral endopeptidase (NEP) and its inhibitor, sialorphin, in colon cancer cells biology.

2012/07/B/NZ3/00209

Keywords:

neutral endopeptidase colon cancer sialorphin,

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej, Wydział Biologii i Biotechnologii

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Martyna Kandefer-Szerszeń 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 477 175 PLN

Project start date (Y-m-d): 2013-07-10

Project end date (Y-m-d): 2017-07-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw HPLC Waters z detektorem Waters 486, systemem kontroli Waters 600-MS i pompami wodnymi (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Opioids, Neutral Endopeptidase, its Inhibitors and Cancer: Is There a Relationship among them?
    Authors:
    Magdalena Mizerska-Dudka, Martyna Kandefer-Szerszeń
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2015, tom: 63, strony: 197-205), Wydawca: Springer Basel
    Status:
    Published
    DOI:
    10.1007/s00005-014-0311-0 - link to the publication
  2. Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development.
    Authors:
    Mizerska-Kowalska Magdalena, Bojarska-Junak Agnieszka, Jakubowicz-Gil Joanna, Kandefer-Szerszeń Martyna.
    Academic press:
    Tumour Biology (rok: 2016, tom: 37, strony: 13355-13368), Wydawca: Springer Basel
    Status:
    Published
    DOI:
    10.1007/s13277-016-5248-y - link to the publication
  3. Neutral endopeptidase (NEP) inhibitors – thiorphan, sialorphin and its derivatives AHNPR, QANPR, QHAPR, and QHNAR exert anti-colorectal cancer activity in vitro through inhibition of cell cycle progression and induction of cell differentiation
    Authors:
    Magdalena Mizerska-Kowalska, Joanna Kreczko-Kurzawa, Barbara Zdzisińska, Arkadiusz Czerwonka, Adrianna Sławińska-Brych, Zbigniew Maćkiewicz, Dawid Nidzworski, Martyna Kandefer-Szerszeń
    Academic press:
    Chemico-Biological Interactions , Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Tumor-associated neutral endopeptidase (tNEP) regulates cell proliferation and TGF-β production in cultures and co-cultures of colon cancer cells with colon fibroblasts.
    Authors:
    Magdalena Mizerska-Kowalska, Katarzyna Sawa-Wejksza, Adrianna Sławińska-Brych, Barbara Zdzisińska
    Conference:
    3rd Congress BIO2018 (rok: 2018, ), Wydawca: Polish Biochemical Society
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
  2. NEP as an endopeptidase is moderately involved in growth and metastatic activity of colon cancer cells in vitro.
    Authors:
    M. Mizerska-Kowalska; A. Bojarska-Junak; J. Jakubowicz-Gil; P. Pożarowski; B. Zdzisińska; M. Kandefer-Szerszeń
    Conference:
    The XVIth Congress of the Polish Society of Experimental and Clincal Immunology (rok: 2017, ), Wydawca: Termedia Publishing House LTD
    Data:
    konferencja 8 -10 czerwca 2017
    Status:
    Published

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