Projects funded by the NCN

Mechanisms of Antidepressant Action of Psilocybin: The Role of 5-HT2B-5-HT1A Receptor Dimerization and GSK-3β Activation...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Agata Faron-Górecka

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Uncovering the NK cell-dependent mechanisms of action of daratumumab in T-ALL

Call: PRELUDIUM 23 , Panel: NZ3

Principal investigator: Karolina Maria Bełdzińska-Gądek

Gdański Uniwersytet Medyczny

New Insight into the Mechanism of Action of Antibiotic Peptides - The Role of the Electric Double Layer

Call: OPUS 27 , Panel: ST4

Principal investigator: prof. Sławomir Marcin Sęk

Uniwersytet Warszawski

Cellular and molecular basis of antifungal activity of metallacarboranes against Candida albicans

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Konrad Kubiński

Katolicki Uniwersytet Lubelski Jana Pawła II

Metabolomic comparison of Mycobacterium tuberculosis and Mycobacterium marinum model organisms in response to antimicrob...

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Marcin Karol Ziomek

Uniwersytet Medyczny w Lublinie

Is metformin having a cardioprotective role in mouse model of autoimmune myocarditis. Evaluation of the mechanism of act...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Monika Marta Stefańska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr Tomasz Krzysztof Prajsnar

Uniwersytet Jagielloński, Wydział Biologii

Actin cytoskeleton disorders as a pro-survival signaling activator and a therapeutic biomarker in Diffuse Large B-cell L...

Call: SONATA BIS 13 , Panel: NZ5

Principal investigator: dr Patryk Górniak

Instytut Hematologii i Transfuzjologii

Modulation of Gi/0 activity by disulfiram as the mechanism preventing tolerance development to the antinociceptive actio...

Call: SONATA BIS 13 , Panel: NZ3

Principal investigator: dr hab. Anna Agata Leśniak

Warszawski Uniwersytet Medyczny

Determination of the molecular mechanism of action of TRIM32 E3 ligase in the regulation of adipocytes' function

Call: PRELUDIUM 22 , Panel: NZ4

Principal investigator: Katia Alghoz

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

The effects of myopathy-causing mutations in TPM2 on tropomyosin-dependent regulation of the thin filament length

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Recep Küçükdoğru

Uniwersytet Kazimierza Wielkiego

Mechanism of action of b-cyclocitral and its derivative in inducing flax resistance to Fusarium oxysporum infection

Call: OPUS 24 , Panel: NZ9

Principal investigator: dr Aleksandra Anna Boba

Uniwersytet Wrocławski, Wydział Biotechnologii

Searching for new chemical compounds inducing resistance of apple to diseases and determination of the molecular mechani...

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Artur Mikiciński

Instytut Ogrodnictwa - Państwowy Instytut Badawczy

Exploring the anticancer, antibacterial and antifungal potential and underlying mechanism of action of plants used in Po...

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Kamila Jadwiga Rachwał

Uniwersytet Przyrodniczy w Lublinie

The role of GPR39 receptor in the mechanism of antidepressant action

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr Katarzyna Młyniec

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Mechanisms of cyclization reactions leading to biologically active compounds catalyzed by iron dependent enzymes.

Call: OPUS 23 , Panel: ST4

Principal investigator: prof. Tomasz Maciej Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera Polskiej Akademii Nauk

Two-dimensional MBene materials as novel photocatalysts for the removal of pharmaceuticals from wastewaters

Call: PRELUDIUM 21 , Panel: ST5

Principal investigator: Dominika Bury

Politechnika Warszawska, Wydział Inżynierii Materiałowej

Tropomyosin isoform Tpm2.3 in regulation of actin dynamics and osteosarcoma metastasis

Call: WEAVE-UNISONO , Panel: NZ5

Principal investigator: prof. Joanna Moraczewska

Uniwersytet Kazimierza Wielkiego w Bydgoszczy

The mechanism of action of pesticides and their impact on rooster's fertility

Call: OPUS 22 , Panel: NZ9

Principal investigator: dr hab. Agnieszka Diana Partyka

Uniwersytet Przyrodniczy we Wrocławiu

Ugly, Dirty and Bad? - the quest for the mechanisms of antioxidant action ofsome nitrogen and sulfur compounds.

Call: OPUS 22 , Panel: ST4

Principal investigator: prof. Grzegorz Robert Litwinienko

Uniwersytet Warszawski, Wydział Chemii

Adaptation of mitochondrial functions to stress caused by plastic dust/pollution; action of mitochondrial retrograde sig...

Call: OPUS 22 , Panel: NZ5

Principal investigator: prof. Joanna Bogumiła Szczepanowska

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Tailoring multicomponent nanometric alloys formed on active support for designing the stable anodes of Solid Oxide Fuel ...

Call: SONATA BIS 11 , Panel: ST5

Principal investigator: dr hab. Beata Maria Bochentyn

Politechnika Gdańska

Diamond and graphite nanoparticles as an antitumor agents - characteristics of antinutritional mechanism of action on an...

Call: PRELUDIUM 2 , Panel: NZ9

Principal investigator: dr Mateusz Krzysztof Wierzbicki

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Nauk o Zwierzętach; Katedra Żywienia Zwierząt i Gospodarki Paszowej

CONTROLLED CRAZING IN BIOPOLYMER SYSTEMS: THE ROLE OF ACTIVE LIQUID ENVIRONMENTS, POLYMER MORPHOLOGY AND CHEMICAL STRUCT...

Call: PRELUDIUM 20 , Panel: ST5

Principal investigator: Ramin Hosseinnezhad

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Research of the mechanism of microbial membrane disorders caused by the presence of copper as an effective antibacterial...

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: dr Agata Ładniak

Katolicki Uniwersytet Lubelski Jana Pawła II

Mitochondria-targeting conjugates as a new anticancer agents

Call: OPUS 21 , Panel: ST4

Principal investigator: prof. Adam Włodzimierz Huczyński

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Chemical composition, antioxidant properties and related molecular mechanisms of action of matcha green tea extracts - i...

Call: PRELUDIUM 20 , Panel: NZ9

Principal investigator: Joanna Alicja Kika

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Nauk o Zdrowiu

The impact and mechanism of action of the lactoperoxidase system modified by using non-physiological substrates on cario...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Marcin Rafał Magacz

Uniwersytet Jagielloński, Collegium Medicum

A new class of antimicrobial compounds. Design, synthesis and study of the mechanism of action.

Call: PRELUDIUM BIS 2 , Panel: NZ7

Principal investigator: dr hab. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Combined experimental and theoretical studies of the catalytic activity of RPE65 enzyme using biomimetic active centre m...

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Adam Maciej Kubas

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Comparison of the mechanism of action of valproic acid and levetiracetam as histone deacetylase inhibitors in ovarian ca...

Call: PRELUDIUM 2 , Panel: NZ7

Principal investigator: Patrycja Katarzyna Kwiecińska

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

Conditional factors of processes and mechanism of interaction between vision for perception and vision for action in rel...

Call: OPUS 2 , Panel: HS6

Principal investigator: dr Piotr Paweł Styrkowiec

Uniwersytet Wrocławski, Wydział Nauk Historycznych i Pedagogicznych

Clinical effect and molecular mechanisms of action of s-adenosylmethionine (SAMe) in patients with primary sclerosing ch...

Call: PRELUDIUM BIS 2 , Panel: NZ5

Principal investigator: prof. Piotr Milkiewicz

Warszawski Uniwersytet Medyczny

Reinforcement learning for semi-active structural control and decentralized mitigation of vibrations: development of new...

Call: OPUS 20 , Panel: ST8

Principal investigator: dr hab. Łukasz Michał Jankowski

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

Uracil in DNA and aberrant DNA methylation/hydroxymethylation as a new biomarkers of multiple myeloma development? A sea...

Call: OPUS 20 , Panel: NZ5

Principal investigator: prof. Ryszard Oliński

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr Natalia Eleonora Małek-Chudzik

Politechnika Wrocławska

In vivo and ex vivo tracking the cocaine's mechanism of action in the medial part of the central amygdala

Call: PRELUDIUM 19 , Panel: NZ4

Principal investigator: Łukasz Damian Bijoch

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Determination of the mechanisms responsible for the mobility of non-integrin laminin receptor (LamR) isoforms, including...

Call: PRELUDIUM 19 , Panel: NZ1

Principal investigator: Ewa Mazurkiewicz

Uniwersytet Wrocławski, Wydział Biotechnologii

Understanding the molecular mechanism of toxic action of the most dangerous trichothecene - T-2 toxin

Call: PRELUDIUM 19 , Panel: NZ9

Principal investigator: Edyta Wioleta Janik-Karpińska

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Novel therapy for pulmonary hypertension with dual mechanism of action: Myo-inositol trispyrophosphate targeting both pu...

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Michał Maria Mączewski

Centrum Medyczne Kształcenia Podyplomowego

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

In vivo effects, underlying signaling pathways and mechanism of action of ghrelin receptor agonist against pathological ...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Piotr Chmielarz

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Gamma-glutamylcysteine ligase participation in the antioxidant mechanism of action of sulodexide on vascular endothelial...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Klaudia Katarzyna Bontor

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

Probiotics and prebiotics- their effect on the chicken intestine health and organism performance, from the pre-hatch per...

Call: OPUS 18 , Panel: NZ9

Principal investigator: dr hab. Katarzyna Stadnicka

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Evaluation of molecular mechanisms of neuroprotective action of dental pulp stromal cells in an ex vivo organotypic mode...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: dr Natalia Helena Bryniarska-Kubiak

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Toxicological features of new two-dimensional nanomaterials from the MBenes family

Call: OPUS 18 , Panel: ST5

Principal investigator: dr hab. Agnieszka Maria Jastrzębska

Politechnika Warszawska, Wydział Mechatroniki

Dual action of HBK-15 – unraveling cellular mechanisms underlying its fast antidepressant-like and procognitive effects...

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Karolina Anna Pytka

Uniwersytet Jagielloński, Collegium Medicum

Synthesis and biochemical properties of sulfonamide antibiotic derivatives together with analyses of changes in their bi...

Call: OPUS 17 , Panel: ST4

Principal investigator: prof. Mariusz Makowski

Uniwersytet Gdański, Wydział Chemii

Specific interactions of new antitumor unsymmetrical bisacridines, UAs, with DNA and ABC proteins and their potential to...

Call: OPUS 17 , Panel: NZ7

Principal investigator: prof. Zofia Mazerska

Politechnika Gdańska

Investigation of parabens' estrogen-like mechanism of action in the context of assessment its influence on the functions...

Call: PRELUDIUM 16 , Panel: NZ7

Principal investigator: Karolina Nowak

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej