New 2(5H)-furanone derivatives with tailored hydrophobicity of substitutents - synthesis, molecular targets, mechanism of action and anticancer activity in vitro in breast cancer cell lines
2016/21/B/NZ7/01766
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_16: Inne zagadnienia pokrewne
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Politechnika Śląska, Wydział Chemiczny
Voivodeship: śląskie
Principal investigator (from the host institution)
prof. Krzysztof Zdzisław Walczak
Number of co-investigators in the project: 7
Call
OPUS 11 – announced on 2016-03-15
- Amount awarded
- 1 073 510 PLN
- Project start date
- 2017-02-09
- Project end date
- 2020-10-08
- Project duration
- 44 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Mieszadło magnetyczne z płytą grzewczą.
- Mieszadło magnetyczne z płytą grzewczą (2 pcs). Cost: 9 000 PLN
- Wymrażacz do pompy membarnowej. Cost: 19 000 PLN
- Wyparka rotacyjna z pompą ptóżniową. Cost: 28 000 PLN
- olejowa pompa próżniowa.
- vortex.
Information in the final report
Publication in academic press/journals (1)
-
Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 – Synthesis, structure-activity relationship and biological evaluation
- Authors:
- A. Byczek-Wyrostek, R. Kitel, K. Rumak, M. Skonieczna, A. Kasprzycka, K. Walczak
- Academic press:
- European Journal of Medicinal Chemistry (year: 2018, volume: 150, pages: 687-697), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ejmech.2018.03.021 – link to the publication