Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Molecular mechanisms of high sensitivity of pathogenic fungi belonging to the genus Cryptococcus to the action of new potential anticancer and antifungal drug - 3-bromopyruvate (3-BP)

2015/19/N/NZ7/00956

Keywords:

Cryptococcus spp. 3-bromopyruvate transport heterologous gene expression glutathione

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ2_1: Molecular genetics
  • NZ6_7: Mycology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Przywara 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 98 447 PLN

Project start date (Y-m-d): 2016-08-19

Project end date (Y-m-d): 2019-08-18

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Microjet - Enbio - autoklaw (5 228 PLN)
  2. Komora laminarna (Polon - nr kat. KL-21) (18 819 PLN)
  3. komputer - HP (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma
    Authors:
    Katarzyna Niedźwiecka, Mariusz Dyląg, Daria Augustyniak, Grażyna Majkowska-Skrobek, Magdalena Cal-Bąkowska, Young H. Ko, Peter L. Pedersen, Andre Goffeau, Stanisław Ułaszewski
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 65614 - 65626), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.11592 - link to the publication
  2. The Cryptococcus neoformans monocarboxylate transporter Jen4 is responsible for increased 3-bromopyruvate sensitivity.
    Authors:
    Katarzyna Niedźwiecka, David Ribas, Margarida Casal, Stanisław Ułaszewski
    Academic press:
    FEMS Yeast Research (rok: 2019, tom: 19, strony: pii: foz029), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/femsyr/foz029 - link to the publication
  3. 3‐Bromopyruvate as a potent anti-cancer therapy in honor and memory of the late Professor André Goffeau
    Authors:
    Young H. Ko, Katarzyna Niedźwiecka, Margarida Casal, Peter L. Pedersen, Stanisław Ułaszewski
    Academic press:
    Yeast (rok: 2018, tom: 2018, strony: 45302), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1002/yea.3367 - link to the publication
  4. The HK2 Dependent Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
    Authors:
    Paweł Lis, Mariusz Dyląg, Katarzyna Niedźwiecka, Young H. Ko, Peter L. Pedersen, Andre Goffeau and Stanisław Ułaszewski
    Academic press:
    Molecules (rok: 2016, tom: 21, strony: pii: E1730), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules21121730 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy