Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Kinetin riboside and its derivatives-analysis of apoptotic properties and mechanism of action in brain tumor cells

2014/13/B/NZ7/02291

Keywords:

kinetin riboside KR small compounds cells proliferation cytotoxicity apoptosis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Eliza Wyszko 

Number of co-investigators in the project: 6

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 862 940 PLN

Project start date (Y-m-d): 2015-01-23

Project end date (Y-m-d): 2019-10-22

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw komputerowy z kolorową drukarką laserową i oprogramowaniem (MS Office, Corel Draw, GraphPad Prism, pakiet programów Adobe) (13 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside
    Authors:
    Marta Orlicka-Płocka, Dorota Gurda-Wozna, Agnieszka Fedoruk-Wyszomirska, Eliza Wyszko
    Academic press:
    Apoptosis (rok: 2020, tom: 25, strony: 835-852), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-020-01637-x - link to the publication
  2. Involvement of kinetin riboside as an adenosine derivative in the metabolic flux determining the serious cellular consequences leading to apoptosis
    Authors:
    Fedoruk-Wyszomirska A., Orlicka-Płocka M., Gurda D., Giel-Pietraszuk M., Krawczyk P., Framski G., Ostrowski T., Wyszko E.
    Academic press:
    Metabolic Engineering (tom: -, strony: -), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Effect of kinetin riboside on proapoptotic activities in human cancer and normal cell lines
    Authors:
    Marta Orlicka-Płocka, Dorota Gurda, Agnieszka Fedoruk-Wyszomirska, Jan Barciszewski, Eliza Wyszko
    Academic press:
    New Biotechnology (rok: 2016, tom: 33S, strony: S168), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nbt.2016.06.1303 - link to the publication
  4. Studies on structure of kinetin riboside and its analogues by variable-temperature NMR
    Authors:
    Baranowski D., Framski G., Wyszko E., Ostrowski T.
    Academic press:
    Journal of Molecular Structure (rok: 2019, tom: 1195, strony: 110-118), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2019.05.112 - link to the publication
  1. Cytotoxic effect if kinetin riboside on mitochondria in 3D-cultures of hepatocyte carcinoma cells
    Authors:
    Fedoruk-Wyszomirska A., Orlicka-Płocka M., Gurda D., Wyszko E.
    Conference:
    8th World Congress on Targeting Mitochondria (rok: 2017, ), Wydawca: WMS Archives
    Data:
    konferencja 23-24.10.2017
    Status:
    Published
  2. Kinetin riboside acts on mitochondria to alter cellular bioenergetics
    Authors:
    Orlicka-Płocka M., Fedoruk-Wyszomirska A., Gurda D., Grobys D, Kmita H., Wyszko E.
    Conference:
    8th World Congress on Targeting Mitochondria (rok: 2017, ), Wydawca: WMS Archives
    Data:
    konferencja 23-24.10.2017
    Status:
    Published
  3. Effect of kinetin riboside on proapoptotic activities in human cancer and normal cell lines
    Authors:
    Marta Orlicka-Płocka, Dorota Gurda, Agnieszka Fedoruk-Wyszomirska, Jan Barciszewski, Eliza Wyszko
    Conference:
    17th Congress on Biotechnology (rok: 2016, ), Wydawca: Elsevier
    Data:
    konferencja 3-6.07.2016
    Status:
    Published
  4. Kinetin riboside – potential anticancer agent acting via rapid cellular ATP depletion leading to mitochondrial electron transport chain disruption
    Authors:
    Orlicka-Płocka M., Fedoruk-Wyszomirska A., Gurda D., Kmita H., Wyszko E
    Conference:
    6th Mitochondrion "Bioenergetics Update" (rok: 2017, ), Wydawca: Uniwersytet im. A. Mickiewicza w Poznaniu
    Data:
    konferencja 8.12.2017
    Status:
    Published
  5. The oxidative phosphorylation increases the mitotoxicity of kinetin riboside in cancer cells
    Authors:
    A. Fedoruk-Wyszomirska, M. Orlicka-Płocka, D. Gurda, Grobys, H. Kmita, E. Wyszko
    Conference:
    9th Congres on Targeting Mitochondria, Berlin (rok: 2018, ), Wydawca: WMS Archives
    Data:
    konferencja 23-25.10
    Status:
    Published
  6. Changes in mitochondrial bioenergetics as a result of kinetin riboside activity analysed in 2D and 3D-cultures of hepatocyte carcinoma cells (wystąpienie ustne)
    Authors:
    Fedoruk-Wyszomirska A., Orlicka-Płocka M., Gurda D., Kmita H., Wyszko E.
    Conference:
    6th Mitochondrion "Bioenergetics Update" (rok: 2017, ), Wydawca: Uniwersytet im. A. Mickiewicza w Poznaniu
    Data:
    konferencja 8.12.2017
    Status:
    Published

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