Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Research of mechanisms of antidepressant action of group II and III mGlu receptor ligands and their role in inducing rapid therapeutic effects in behavioral models of depression.

2014/13/B/NZ7/02222

Keywords:

glutamate ketamine antidepressant drugs mGlu receptors

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Pałucha-Poniewiera 

Number of co-investigators in the project: 6

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 550 820 PLN

Project start date (Y-m-d): 2015-01-23

Project end date (Y-m-d): 2018-01-22

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do pionowej elektroforezy białeki kwasów nukleinowych dla czterech żeli (14 500 PLN)
  2. Zasilacz do aparatu elektroforetycznego (5 200 PLN)
  3. Aparat do transferu białek z żelu poliakrylamidowego na membranę nitrocelulozową. (10 367 PLN)
  4. Blok grzejny z wytrząsaniem (11 700 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (3)
  1. Role of AMPA receptor stimulation and TrkB signaling in the antidepressant-like effect of ketamine co-administered with a group II mGlu receptor antagonist, LY341495, in the forced swim test in rats.
    Authors:
    Pałucha-Poniewiera Agnieszka, Podkowa Karolina, Pilc Andrzej
    Academic press:
    Behavioural Pharmacology (rok: 2019, tom: 30, strony: 471-477), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/FBP.0000000000000471. - link to the publication
  2. The involvement of monoaminergic neurotransmission in the antidepressant-like action of scopolamine in the tail suspension test.
    Authors:
    Pałucha-Poniewiera Agnieszka, Podkowa Karolina, Lenda Tomasz, Pilc Andrzej
    Academic press:
    Progress in Neuropsychopharmacology and Biological Psychiatry (rok: 2017, tom: 79, strony: 155-161), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2017.06.022 - link to the publication
  3. A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action
    Authors:
    Podkowa Karolina, Rzeźniczek Szymon, Marciniak Marcin, Acher Francine, Pilc Andrzej, Pałucha-Poniewiera Agnieszka
    Academic press:
    Neuropharmacology (rok: 2015, tom: 97, strony: 338-345), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2015.05.039 - link to the publication
  4. Antidepressant-like effects of scopolamine in mice are enhanced by the group II mGlu receptor antagonist LY341495
    Authors:
    Podkowa Karolina, Podkowa Adrian, Sałat Kinga, Lenda Tomasz, Pilc Andrzej, Pałucha-Poniewiera Agnieszka
    Academic press:
    Neuropharmacology (rok: 2016, tom: 111, strony: 169-179), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2016.08.031 - link to the publication
  5. Glutamate-Based Drug Discovery for Novel Antidepressants
    Authors:
    Pałucha-Poniewiera Agnieszka, Pilc Andrzej
    Academic press:
    Expert Opinion of Drug Discovery (rok: 2016, tom: 11, strony: 873-883), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/17460441.2016.1213234 - link to the publication
  6. Group II mGlu receptor antagonist LY341495 enhances the antidepressant-like effects of ketamine in the forced swim test in rats.
    Authors:
    Podkowa Karolina, Pochwat Bartłomiej, Brański Piotr, Pilc Andrzej, Pał ucha-Poniewiera Agnieszka
    Academic press:
    Psychopharmacology (rok: 2016, tom: 233, strony: 2901-2914), Wydawca: Springer Berlin Heidelberg
    Status:
    Published
    DOI:
    10.1007/s00213-016-4325-7. - link to the publication
  1. The potential antidepressant effect of the joint administration of ketamine and mGLU2/3 receptor antagonist, LY341495 in the forced swim test in rats
    Authors:
    Podkowa Karolina, Pilc Andrzej, Pałucha-Poniewiera Agnieszka
    Conference:
    28th Congress of the European-College-of-Neuropsychopharmacology (ECNP) (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 29 sierpnia - 1 września 2015
    Status:
    Published
  2. Pro-depressive-like effects of mGlu4 selective agonist LSP4-2022 in mice
    Authors:
    Rzeźniczek Szymon, Podkowa Karolina, Marciniak Marcin, Acher Francine, Pilc Andrzej, Pałucha-Poniewiera Agnieszka
    Conference:
    28th Congress of the European-College-of-Neuropsychopharmacology (ECNP) (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 29 sierpnia - 1 września 2015
    Status:
    Published
  3. Possible mechanisms involved in the antidepressant-like effect of ketamine co-administered with the group II mGlu receptor antagonist, LY341495 in the forced swim test in rats.
    Authors:
    Pałucha-Poniewiera Agnieszka, Podkowa Karolina
    Conference:
    Biennial Meeting of European Behavioural Pharmacology Society (EBPS) (rok: 2017, ), Wydawca: EBPS
    Data:
    konferencja 31.08-03.09.2017
    Status:
    Published

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