Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanism of unique action of clozapine in the context of GPCR.

2014/15/B/NZ7/01019

Keywords:

schizophrenia clozapine receptor heterodimerization PLA BDNF MMP-9 intracellular signaling

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agata Faron-Górecka 

Number of co-investigators in the project: 4

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 752 160 PLN

Project start date (Y-m-d): 2015-09-22

Project end date (Y-m-d): 2018-09-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. mikroskop fluorescencyjny (150 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  • Book publications / chapters in book publications (1)
  1. Effect of clozapine on ketamine-induced deficits in attentional set shift task in mice.
    Authors:
    Szlachta M, Pabian P, Kuśmider M, Solich J, Kolasa M, Żurawek D, Dziedzicka-Wasylewska M, Faron-Górecka A
    Academic press:
    Psychopharmacology (rok: 2017, tom: brak, strony: 2103-2112), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-017-4613-x - link to the publication
  2. Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex
    Authors:
    Szlachta M, Kusmider M, Pabian P, Solich J, Kolasa M, Żurawek D, Dziedzicka-Wasylewska M, Faron-Górecka A
    Academic press:
    Frontiers in Molecular Neurosciences (rok: 2018, tom: Volume 11, strony: 45305), Wydawca: www.frontiersin.org
    Status:
    Published
    DOI:
    10.3389/fnmol.2018.00040 - link to the publication
  3. Clozapine administered repeatedly following pretreatment with ketamine enhances dopamine D2 receptors in the dopamine mesolimbic pathway in mice brain.
    Authors:
    Szlachta M, Kusmider M, Solich J, Kolasa M, Pabian P, Dziedzicka-Wasylewska M, Faron-Górecka A
    Academic press:
    Neuroscience Letter (rok: 2019, tom: 707, strony: -), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2019.134292 - link to the publication
  1. Chronic administration of clozapine increases the level of serotonin 5-HT1A receptors heterodimerization with 5-HT2A or dopamine D2 receptors in the mouse cortex
    Authors:
    Marta Szlachta, Agata Faron-Górecka, Maciej Kuśmider, Magdalena Kolasa, Joanna Solich, Marta Dziedzicka-Wasylewska
    Conference:
    ECNP Workshop for young scientists in Nice (rok: 2018, ), Wydawca: Elsevier
    Data:
    konferencja 15-18.03.2018
    Status:
    Published
    DOI:
    link to the publication
  2. Effect of clozapine on BDNF and MMP-9 levels in the context of cognitive deficits
    Authors:
    Faron-Górecka A, Szlachta M, Kuśmider M, Pabian P, Solich J, Kolasa M, Żurawek D, Dziedzicka-Wasylewska M
    Conference:
    Gordon Research Conference on Neurotrophic Factors (rok: 2017, ), Wydawca: Gordon Research Conference
    Data:
    konferencja 06/04/2017 - 06/09/2017
    Status:
    Published
  3. The impact of clozapine on the dopamine D2 receptor binding in ketamine induced attentional set shift task model.
    Authors:
    Marta Dubiel, Agata Faron-Górecka, Paulina Pabian, Maciej Kuśmider, Magdalena Kolasa, Joanna Solich, Dariusz Żurawek, Marta Dziedzicka-Wasylewska
    Conference:
    Dopamine 2016 (rok: 2016, ), Wydawca: Campus of the Medical University of Vienna, Austria
    Data:
    konferencja 5-8 wrzesień 2016
    Status:
    Published
  4. Effect of clozapine on ketamine–induced cognitive impairments in mice
    Authors:
    Marta Dubiel, Agata Faron-Górecka, Paulina Pabian, Marta Dziedzicka-Wasylewska
    Conference:
    Neuronus 2016 (rok: 2016, ), Wydawca: IBRO & IRUN Neuroscience Forum
    Data:
    konferencja 22-24 kwietnia 2016
    Status:
    Published
  1. Understanding GPCR dimerization
    Authors:
    Faron-Gorecka A, Szlachta M, Kolasa M, Solich J, Górecki A, Kuśmider M, Zurawek D, Dziedzicka-Wasylewska M
    Book:
    Methods in cell biology (rok: 2018, tom: -, strony: 45315), Wydawca: Elsevier
    Status:
    Published

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