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Molecular mechanism of unique action of clozapine in the context of GPCR.

2014/15/B/NZ7/01019

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Agata Faron-Górecka

Number of co-investigators in the project: 4

Call

OPUS 8 – announced on 2014-09-15

Amount awarded
752 160 PLN
Project start date
2015-09-22
Project end date
2018-09-21
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. mikroskop fluorescencyjny. Cost: 150 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex

    Authors:
    Szlachta M, Kusmider M, Pabian P, Solich J, Kolasa M, Żurawek D, Dziedzicka-Wasylewska M, Faron-Górecka A
    Academic press:
    Frontiers in Molecular Neurosciences (year: 2018, volume: Volume 11, pages: 46036), Publisher: www.frontiersin.org
    Status:
    Published
    DOI:
    10.3389/fnmol.2018.00040 – link to the publication

  2. Effect of clozapine on ketamine-induced deficits in attentional set shift task in mice.

    Authors:
    Szlachta M, Pabian P, Kuśmider M, Solich J, Kolasa M, Żurawek D, Dziedzicka-Wasylewska M, Faron-Górecka A
    Academic press:
    Psychopharmacology (year: 2017, volume: brak, pages: 2103-2112), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-017-4613-x – link to the publication

  3. Clozapine administered repeatedly following pretreatment with ketamine enhances dopamine D2 receptors in the dopamine mesolimbic pathway in mice brain.

    Authors:
    Szlachta M, Kusmider M, Solich J, Kolasa M, Pabian P, Dziedzicka-Wasylewska M, Faron-Górecka A
    Academic press:
    Neuroscience Letter (year: 2019, volume: 707, pages: -), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2019.134292 – link to the publication

Articles in post-conference publications (4)

  1. Effect of clozapine on ketamine–induced cognitive impairments in mice

    Authors:
    Marta Dubiel, Agata Faron-Górecka, Paulina Pabian, Marta Dziedzicka-Wasylewska
    Conference:
    Neuronus 2016 (year: 2016, pages: 72), Publisher: IBRO & IRUN Neuroscience Forum
    Date:
    conference 22-24 kwietnia 2016
    Status:
    Published

  2. Chronic administration of clozapine increases the level of serotonin 5-HT1A receptors heterodimerization with 5-HT2A or dopamine D2 receptors in the mouse cortex

    Authors:
    Marta Szlachta, Agata Faron-Górecka, Maciej Kuśmider, Magdalena Kolasa, Joanna Solich, Marta Dziedzicka-Wasylewska
    Conference:
    ECNP Workshop for young scientists in Nice (year: 2018, pages: S7-S8), Publisher: Elsevier
    Date:
    conference 15-18.03.2018
    Status:
    Published
    DOI:
    link to the publication

  3. Effect of clozapine on BDNF and MMP-9 levels in the context of cognitive deficits

    Authors:
    Faron-Górecka A, Szlachta M, Kuśmider M, Pabian P, Solich J, Kolasa M, Żurawek D, Dziedzicka-Wasylewska M
    Conference:
    Gordon Research Conference on Neurotrophic Factors (year: 2017, pages: brak), Publisher: Gordon Research Conference
    Date:
    conference 06/04/2017 - 06/09/2017
    Status:
    Published

  4. The impact of clozapine on the dopamine D2 receptor binding in ketamine induced attentional set shift task model.

    Authors:
    Marta Dubiel, Agata Faron-Górecka, Paulina Pabian, Maciej Kuśmider, Magdalena Kolasa, Joanna Solich, Dariusz Żurawek, Marta Dziedzicka-Wasylewska
    Conference:
    Dopamine 2016 (year: 2016, pages: brak), Publisher: Campus of the Medical University of Vienna, Austria
    Date:
    conference 5-8 wrzesień 2016
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Understanding GPCR dimerization

    Authors:
    Faron-Gorecka A, Szlachta M, Kolasa M, Solich J, Górecki A, Kuśmider M, Zurawek D, Dziedzicka-Wasylewska M
    Book:
    Methods in cell biology (year: 2018, volume: -, pages: 46046), Publisher: Elsevier
    Status:
    Published

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