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The mechanism of neurotoxic action of benzophenone-3

2014/15/B/NZ7/00892

Keywords

Descriptors

  • NZ3_6: Neurobiologia komórkowa
  • NZ3_7: Przekaźnictwo sygnału
  • NZ7_15: Toksykologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Bogusława Budziszewska

Number of co-investigators in the project: 6

Call

OPUS 8 – announced on 2014-09-15

Amount awarded
997 200 PLN
Project start date
2015-07-13
Project end date
2018-07-12
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Ramiona do przeprowadzenia mikrodializy na wolnoporuszających się zwierzętach. Cost: 18 450 PLN
  2. Stolik stereotaktyczny dla szczurów. Cost: 30 000 PLN
  3. Termocykler RT-PCR. Cost: 120 000 PLN
  4. aparat do pomiaru stężenia i czystości DNA/RNA.

Information in the final report

Publication in academic press/journals (3)

  1. The effects of benzophenone-3 on apoptosis and the expression of sex hormone receptors in the frontal cortex and hippocampus of rats

    Authors:
    Krzyżanowska W., Pomierny B., Starek-Świechowicz B., Broniowska Ż., Strach B., Budziszewska B.
    Academic press:
    Toxicology Letters (year: 2018, volume: 296, pages: 63-72), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2018.08.006 – link to the publication

  2. Benzophenone-3 passes through the blood-brain barrier, increases the level of extracellular glutamate, and induces apoptotic processes in the hippocampus and frontal cortex of rats

    Authors:
    Pomierny B., Krzyżanowska W., Broniowska Ż., Strach B., Bystrowska B., Starek-Świechowicz B., Maciejska A., Skórkowska A., Wesołowska J., Walczak M., Budziszewska B.
    Academic press:
    Toxicological Sciences (year: 2019, volume: 171, pages: 485-500), Publisher: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/toxsci/kfz160 – link to the publication

  3. Effect of combined prenatal and adult benzophenone-3 dermal exposure on factors regulating neurodegenerative processes, blood hormone levels, and hematological parameters in female rats

    Authors:
    Skórkowska A., Maciejska A., Pomierny B., Krzyżanowska W., Starek-Świechowicz B., Bystrowska B., Broniowska Ż., Kazek G., Budziszewska B.
    Status:
    Accepted for publication

Articles in post-conference publications (5)

  1. Mechanizm neurotoksycznego działania benzofenonu-3

    Authors:
    Weronika Krzyżanowska, Beata Starek-Świechowicz, Żaneta Broniowska, Bartosz Pomierny, Beata Bystrowska, Bogusława Budziszewska
    Conference:
    Różne oblicza Toksykologii (year: 2017, pages: 107), Publisher: Polskie Towarzystwo Toksykologiczne
    Date:
    conference 19-22 wrzesień 2017
    Status:
    Published

  2. Benzophenone-3 concentration and its effect on oxidative stress markers in rat brain

    Authors:
    Bogusława Budziszewska, Żaneta Broniowska, Bartosz Pomierny, Beata Starek-Świechowicz, Weronika Krzyżanowska, Beata Bystrowska, Beata Strach
    Conference:
    18th World Kongress of Basic and Clinical Pharmacology (year: 2018, pages: 483), Publisher: Japanese Pharmcological Society
    Date:
    conference 01.07-06.07. 2018
    Status:
    Published

  3. Benzophenone-3 and its proapoptotic activity in the rat brain

    Authors:
    Bartosz Pomierny, Weronika Krzyżanowska, Beata Strach, Beata Starek-Świechowicz, Żaneta Broniowska, Bogusława Budziszewska
    Conference:
    18th World Kongress of Basic and Clinical Pharmacology (year: 2018, pages: 323), Publisher: Japanese Pharmcological Society
    Date:
    conference 01.07-06.07. 2018
    Status:
    Published

  4. The effect of benzophenone-3 on the steroid receptors expression in the brain

    Authors:
    Beata Starek-Swiechowicz, Zaneta Broniowska, Bartosz PomiernWeronika Krzyzanowska, Beata Strach, Agnieszka Basta-Kaim, Boguslawa Budziszewska
    Conference:
    18th World Kongress of Basic and Clinical Pharmacology (year: 2018, pages: 323), Publisher: Japanese Pharmcological Society
    Date:
    conference 01.07-06.07. 2018
    Status:
    Published

  5. Benzophenone-3 affects glutaminergic system in the rat brain.

    Authors:
    Weronika Krzyżanowska, Bartosz Pomierny, Beata Starek-Świechowicz, Żaneta Broniowska, Beata Strach, Beata Bystrowska, Bogusława Budziszewska
    Conference:
    18th World Kongress of Basic and Clinical Pharmacology (year: 2018, pages: 479), Publisher: Japanese Pharmcological Society
    Date:
    conference 01.07-06.07. 2018
    Status:
    Published

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