Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Role of the NLRP3 inflammasome in the mechanisms of action of antidepressant drugs - study in an animal model of depression

2015/17/N/NZ7/00924

Keywords:

depression inflammasome NLRP3 primary microglia cultures

Descriptors:

  • NZ6_3: Animal immunology
  • NZ5_3: Pathogenesis of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Trojan 

Number of co-investigators in the project: 3

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 149 784 PLN

Project start date (Y-m-d): 2016-03-24

Project end date (Y-m-d): 2020-03-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (10)
  1. Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway.
    Authors:
    Trojan Ewa, Chamera Katarzyna, Bryniarska Natalia, Kotarska Katarzyna, Leśkiewicz Monika, Regulska Magda, Basta-Kaim Agnieszka
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 56, strony: 5365-5380), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1458-1. - link to the publication
  2. Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures
    Authors:
    Ślusarczyk J, Trojan E, Głombik K, Piotrowska A, Budziszewska B, Kubera M, Popiołek-Barczyk K, Lasoń W, Mika J, Basta-Kaim A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 18, strony: 23), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19071965. - link to the publication
  1. Effect of reboxetine treatment in lipopolysaccharide (LPS)- stimulated microglial cells
    Authors:
    Trojan E., Chamera K., Bryniarska N., Basta-Kaim A.
    Conference:
    3rd Central European Biomedical Congress News on biomarker discovery and research innovations in medicine and biomedical sciences" (rok: 2018, ), Wydawca: Institute of Pharmacology Polish Academy of Sciences in Cracow, Faculty of Medicine Jagiellonian University Medical College
    Data:
    konferencja 15-18.09.201 8
    Status:
    Published
  2. AC-YVAD-CMK prevents NLRP3 inflammasome activation and pyroptosis in animal model of depression.
    Authors:
    Ewa Trojan, Anna Kurek, Katarzyna Chamera, Natalia Bryniasrka, Magda Szuster, Martyna Strzelec, Agnieszka Basta-Kaim
    Conference:
    XIV European Meeting on Glial Cells in Health and Disease (rok: 2019, ), Wydawca: Glia
    Data:
    konferencja 10-13.07.2019
    Status:
    Published
  3. THE EFFECT OF TIANEPTINE ADMINISTARTION ON NLRP3 INFLAMMASOME ACTIVATION IN PRIMARY MICROGLIAL CULTURES
    Authors:
    E. Trojan, K. Chamera, K. Głombik, K. Kotarska, N. Bryniarska, A. Basta-Kaim
    Conference:
    XLVth Winter School of Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University in Kraków Signaling – from molecules to cells and back" (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 9-14.02.2018
    Status:
    Published
  4. THE IMPACT OF FLUOXETINE ON THE ACTIVITY OF PRIMARY MICROGLIAL CULTURES – STUDY IN AN ANIMAL MODEL OF DEPRESSION
    Authors:
    Ewa Trojan, Joanna Slusarczyk, Katarzyna Chamera, Anna Kurek, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    XI Copernican International Young Scientists Conference (rok: 2017, ), Wydawca: Faculty of Chemistry NCU in Toruń, Poland
    Data:
    konferencja 28-30.06.2017
    Status:
    Published
  5. The influence of reboxetine on inflammatory response mediated by the NLRP3/caspase-1/IL-1β axis in primary microglial cultures
    Authors:
    Martyna Strzelec, Ewa Trojan, Katarzyna Chamera, Magda Szuster, Natalia Bryniarska, Agnieszka Basta-Kaim
    Conference:
    5th International Conference of Cell Biology (ICCB) (rok: 2019, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 10-12.05.2019
    Status:
    Published
  6. Wpływ leku przeciwdepresyjnego – tianeptyny – na ekspresję podjednostek inflammasomu NLRP3 w pierwotnych hodowlach mikrogleju – badania w zwierzęcym modelu depresji
    Authors:
    E. Trojan, K. Chamera, K. Kotarska, N. Bryniarska, A. Basta-Kaim
    Conference:
    X Interdyscyplinarna konferencja naukowa TYGIEL: Interdyscyplinarność kluczem do rozwoju" (rok: 2018, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 17-18.03.201 8
    Status:
    Published
  7. Effect of desipramine treatment in lipopolysaccharide (LPS)- stimulated microglial cells
    Authors:
    Ewa Trojan, Katarzyna Chamera, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    4th International Conference of Cell Biology (ICCB) (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 11-12.05.201 8
    Status:
    Published
  8. THE IMPACT OF PRENATAL STRESS AND VENLAFAXINE TREATMENT ON THE BRAIN INFLAMMASOME NLRP3 PATHWAY
    Authors:
    Ewa Trojan, Katarzyna Chamera, Agnieszka Basta-Kaim
    Conference:
    13th EFIS-EJI Tatra Immunology Conference (rok: 2018, ), Wydawca: European Federation of Immunological Societies, European Journal of Immunology
    Data:
    konferencja 9-13.06.2018
    Status:
    Published
  9. The effect of chronic tianeptine administration on NLRP3 inflammasome pathway – study in an animal model of depression.
    Authors:
    Ewa Trojan, Anna Kurek, Katarzyna Chamera, Joanna Slusarczyk, Katarzyna Głombik, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    19th European Congress of Endocrinology (rok: 2017, ), Wydawca: Endocrine Abstracts
    Data:
    konferencja 20-23.05.2017
    Status:
    Published
  10. The influence of tianeptine on the activity of primary microglial cultures
    Authors:
    Ewa Trojan, Katarzyna Chamera, Katarzyna Kotarska, Natalia Bryniarska, Agnieszka Basta-Kaim
    Conference:
    Neuronus IBRO Neuroscience Forum (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 20-22.04.201 8
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy