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Role of the NLRP3 inflammasome in the mechanisms of action of antidepressant drugs - study in an animal model of depression

2015/17/N/NZ7/00924

Keywords

Descriptors

  • NZ6_3: Immunologia zwierząt
  • NZ5_3: Patogeneza chorób człowieka
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Ewa Izabela Trojan

Number of co-investigators in the project: 3

Call

PRELUDIUM 9 – announced on 2015-03-16

Amount awarded
149 784 PLN
Project start date
2016-03-24
Project end date
2020-03-23
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

  1. Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures

    Authors:
    Ślusarczyk J, Trojan E, Głombik K, Piotrowska A, Budziszewska B, Kubera M, Popiołek-Barczyk K, Lasoń W, Mika J, Basta-Kaim A.
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 18, pages: 23), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19071965. – link to the publication

  2. Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway.

    Authors:
    Trojan Ewa, Chamera Katarzyna, Bryniarska Natalia, Kotarska Katarzyna, Leśkiewicz Monika, Regulska Magda, Basta-Kaim Agnieszka
    Academic press:
    Molecular Neurobiology (year: 2019, volume: 56, pages: 5365-5380), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1458-1. – link to the publication

Articles in post-conference publications (10)

  1. Effect of desipramine treatment in lipopolysaccharide (LPS)- stimulated microglial cells

    Authors:
    Ewa Trojan, Katarzyna Chamera, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    4th International Conference of Cell Biology (ICCB) (year: 2018, pages: 129), Publisher: Jagiellonian University in Cracow
    Date:
    conference 11-12.05.201 8
    Status:
    Published

  2. The influence of tianeptine on the activity of primary microglial cultures

    Authors:
    Ewa Trojan, Katarzyna Chamera, Katarzyna Kotarska, Natalia Bryniarska, Agnieszka Basta-Kaim
    Conference:
    Neuronus IBRO Neuroscience Forum (year: 2018, pages: 64), Publisher: Jagiellonian University in Cracow
    Date:
    conference 20-22.04.201 8
    Status:
    Published

  3. The effect of chronic tianeptine administration on NLRP3 inflammasome pathway – study in an animal model of depression.

    Authors:
    Ewa Trojan, Anna Kurek, Katarzyna Chamera, Joanna Slusarczyk, Katarzyna Głombik, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    19th European Congress of Endocrinology (year: 2017, pages: GP158), Publisher: Endocrine Abstracts
    Date:
    conference 20-23.05.2017
    Status:
    Published

  4. Wpływ leku przeciwdepresyjnego – tianeptyny – na ekspresję podjednostek inflammasomu NLRP3 w pierwotnych hodowlach mikrogleju – badania w zwierzęcym modelu depresji

    Authors:
    E. Trojan, K. Chamera, K. Kotarska, N. Bryniarska, A. Basta-Kaim
    Conference:
    X Interdyscyplinarna konferencja naukowa TYGIEL: Interdyscyplinarność kluczem do rozwoju (year: 2018, pages: 310), Publisher: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Date:
    conference 17-18.03.201 8
    Status:
    Published

  5. THE IMPACT OF PRENATAL STRESS AND VENLAFAXINE TREATMENT ON THE BRAIN INFLAMMASOME NLRP3 PATHWAY

    Authors:
    Ewa Trojan, Katarzyna Chamera, Agnieszka Basta-Kaim
    Conference:
    13th EFIS-EJI Tatra Immunology Conference (year: 2018, pages: 1), Publisher: European Federation of Immunological Societies, European Journal of Immunology
    Date:
    conference 9-13.06.2018
    Status:
    Published

  6. The influence of reboxetine on inflammatory response mediated by the NLRP3/caspase-1/IL-1β axis in primary microglial cultures

    Authors:
    Martyna Strzelec, Ewa Trojan, Katarzyna Chamera, Magda Szuster, Natalia Bryniarska, Agnieszka Basta-Kaim
    Conference:
    5th International Conference of Cell Biology (ICCB) (year: 2019, pages: 187), Publisher: Jagiellonian University in Cracow
    Date:
    conference 10-12.05.2019
    Status:
    Published

  7. AC-YVAD-CMK prevents NLRP3 inflammasome activation and pyroptosis in animal model of depression.

    Authors:
    Ewa Trojan, Anna Kurek, Katarzyna Chamera, Natalia Bryniasrka, Magda Szuster, Martyna Strzelec, Agnieszka Basta-Kaim
    Conference:
    XIV European Meeting on Glial Cells in Health and Disease (year: 2019, pages: E573-E574), Publisher: Glia
    Date:
    conference 10-13.07.2019
    Status:
    Published

  8. THE EFFECT OF TIANEPTINE ADMINISTARTION ON NLRP3 INFLAMMASOME ACTIVATION IN PRIMARY MICROGLIAL CULTURES

    Authors:
    E. Trojan, K. Chamera, K. Głombik, K. Kotarska, N. Bryniarska, A. Basta-Kaim
    Conference:
    XLVth Winter School of Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University in Kraków Signaling – from molecules to cells and back (year: 2018, pages: 92), Publisher: Jagiellonian University in Cracow
    Date:
    conference 9-14.02.2018
    Status:
    Published

  9. THE IMPACT OF FLUOXETINE ON THE ACTIVITY OF PRIMARY MICROGLIAL CULTURES – STUDY IN AN ANIMAL MODEL OF DEPRESSION

    Authors:
    Ewa Trojan, Joanna Slusarczyk, Katarzyna Chamera, Anna Kurek, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    XI Copernican International Young Scientists Conference (year: 2017, pages: 109), Publisher: Faculty of Chemistry NCU in Toruń, Poland
    Date:
    conference 28-30.06.2017
    Status:
    Published

  10. Effect of reboxetine treatment in lipopolysaccharide (LPS)- stimulated microglial cells

    Authors:
    Trojan E., Chamera K., Bryniarska N., Basta-Kaim A.
    Conference:
    3rd Central European Biomedical Congress News on biomarker discovery and research innovations in medicine and biomedical sciences (year: 2018, pages: 1), Publisher: Institute of Pharmacology Polish Academy of Sciences in Cracow, Faculty of Medicine Jagiellonian University Medical College
    Date:
    conference 15-18.09.201 8
    Status:
    Published

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