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Information on the principal investigator and host institution

Information of the project and the call

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Molecular mechanism of action of antidepressant drugs in the in vitro model of contact allergy in the human cell line HaCat and mouse dendritic precursor JAWSII cells

2014/13/N/NZ6/00639

Keywords:

antidepresant drus cytokines contact hypersensitivity keratinocytes dendritic cells

Descriptors:

  • NZ3_7: Signal transduction
  • NZ6_8: Other related subjects
  • NZ7_2: Environment and health risks

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Katarzyna Curzytek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 7 - announced on 2014-03-17

Amount awarded: 149 890 PLN

Project start date (Y-m-d): 2015-03-10

Project end date (Y-m-d): 2019-03-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction is connected with their suppressive effect on NKT and CD8(+) T cells but not on TCR delta T cells.
    Authors:
    Curzytek K, Kubera M, Majewska-Szczepanik M, Szczepanik M, Ptak W, Duda W, Leśkiewicz M, Basta-Kaim A, Budziszewska B, Regulska M, Korzeniak B, Głombik K, Maes M, Lasoń W.
    Academic press:
    International Immunopharmacology (rok: 2015, tom: 28(2), strony: 1091-1096), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.intimp.2015.08.001 - link to the publication
  2. Immune-Regulatory and Molecular Effects of Antidepressants on the Inflamed Human Keratinocyte HaCaT Cell Line
    Authors:
    Curzytek K., Maes M., Kubera M.
    Academic press:
    Neurotoxicity Research (rok: 2021, tom: tymczasowy brak, strony: tymczasowy brak), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-021-00367-5 - link to the publication
  1. Antidepressant drugs inhibit production of proinflammatory cytokines in mouse dendritic precursor JAWSII cells
    Authors:
    Katarzyna Curzytek, Barbara Korzeniak, Marta Kubera
    Conference:
    NEURONUS 2018 IBRO Neuroscience Forum (rok: 2018, ), Wydawca: www.neuronusforum.pl
    Data:
    konferencja 20 - 22 kwietnia 2018
    Status:
    Published
  2. Antidepressant drugs are involved in the regulation of inflammatory response in the stimulated human cell line HaCaT
    Authors:
    Katarzyna Curzytek, Marta Kubera
    Conference:
    Neuronus 2016, IBRO and IRUN Neuroscience Forum (rok: 2016, ), Wydawca: www.neuronusforum.pl
    Data:
    konferencja 22-24 kwietnia 2016
    Status:
    Published
  3. Antidepressant drugs inhibit production of inflammatory factors in stimulated human Hacat cells
    Authors:
    Katarzyna Curzytek, Marta Kubera
    Conference:
    12th EFIS-EJI Tatra Immunology Conference, Strbske Pleso, Słowacja (rok: 2016, ), Wydawca: EFIS
    Data:
    konferencja 3-7 września 2016
    Status:
    Published

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