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Information of the project and the call

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Insights into biological activity and mechanism of action of novel styrylquinazoline derivatives as tyrosine kinase inhibitors.

2016/23/N/NZ7/00351

Keywords:

styrylquinazolines tyrosine kinase inhibitors multidirectional targeted therapy

Descriptors:

  • NZ3_7: Signal transduction
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_16:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Śląski w Katowicach, Wydział Matematyki, Fizyki i Chemii

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Katarzyna Malarz 

Number of co-investigators in the project: 3

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 99 600 PLN

Project start date (Y-m-d): 2017-09-29

Project end date (Y-m-d): 2019-09-28

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Acid selective pro-dye for cellular compartments
    Authors:
    B. Czaplińska, K. Malarz, A. Mrozek-Wilczkiewicz, R. Musiol
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 15304), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-50734-8 - link to the publication
  2. Design and synthesis of anticancer 1-hydroxynaphthalene-2- carboxanilides with a p53 independent mechanism of action
    Authors:
    E. Spaczyńska, A. Mrozek-Wilczkiewicz, K. Malarz, J. Kos, T. Gonec, M. Oravec, R. Gawecki, A. Bak, J. Dohanosova, I. Kapustikova, T. Liptaj, J. Jampilek, R. Musiol
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 6387), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-42595-y - link to the publication
  3. Impact of temperature on the physicochemical, structural and biological features of copper-silica nanocomposites
    Authors:
    M. Dulski, K. Dudek, J. Podwórny, S. Sułowicz, Z. Piotrowska-Seget, K. Malarz, A. Mrozek-Wilczkiewicz, K. Wolnica, K. Matus, J. Peszke, A. Nowak
    Academic press:
    Materials Science and Engineering: C (rok: 2020, tom: 107, strony: 110274), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.110274 - link to the publication
  4. 4'-Phenyl-2,2':6',2''-terpyridine Derivatives Containing 1-Substituted-2,3-Triazole Ring: Synthesis, Characterization and Anticancer Activity
    Authors:
    D. Zych, A. Slodek, S. Krompiec, K. Malarz, A. Mrozek-Wilczkiewicz, R. Musiol
    Academic press:
    ChemistrySelect (rok: 2018, tom: 3, strony: 7009–7017), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/slct.201801204 - link to the publication
  5. Impact of thiosemicarbazones on the accumulation of PpIX and the expression of the associated genes
    Authors:
    R. Gawecki, K. Malarz, M. Rejmund, J. Polanski, A. Mrozek-Wilczkiewicz
    Academic press:
    Journal of Photochemistry and Photobiology B: Biology (rok: 2019, tom: 199, strony: 111585), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotobiol.2019.111585 - link to the publication
  6. Influence of the substituent D/A at the 1,2,3- triazole ring on novel terpyridine derivatives: synthesis and properties
    Authors:
    D. Zych, A. Slodek, D. Zimny, S. Golba, K. Malarz, A. Mrozek-Wilczkiewicz
    Academic press:
    RSC Advances (rok: 2019, tom: 9, strony: 16554-16564), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9ra02655j - link to the publication
  7. Physicochemical and structural features of heat treated silver-silica nanocomposite and their impact on biological properties
    Authors:
    M. Dulski, J. Peszke, J. Włodarczyk, S. Sułowicz, Z. Piotrowska-Seget, K. Dudek, J. Podwórny, K. Malarz, A. Mrozek-Wilczkiewicz, M. Zubko, A. Nowak
    Academic press:
    Materials Science and Engineering C (rok: 2019, tom: 103, strony: 109790), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.109790 - link to the publication
  8. The p53 stabilizing agent CP-31398 and multi-kinase inhibitors. Designing, synthesizing and screening of styrylquinazoline series
    Authors:
    J. Mularski, K. Malarz, M. Pacholczyk, R. Musiol
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 163, strony: 610-625), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.12.012 - link to the publication
  9. Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety
    Authors:
    A. Mrozek-Wilczkiewicz, K. Malarz, M. Rejmund, J. Polanski, R. Musiol
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 171, strony: 180-194), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.03.027 - link to the publication
  10. The synthesis and anticancer activity of 2-styrylquinoline derivatives. A p53 independent mechanism of action
    Authors:
    A. Mrozek-Wilczkiewicz, M. Kuczak, K. Malarz, W. Cieślik, E. Spaczyńska, R. Musiol
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 177, strony: 338-349), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.05.061 - link to the publication

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