Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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New mollecular mechanisms polychorinated aromatic hydrocarbons (PAH) mixture action in human granulosa cells.

2015/17/B/NZ7/02954

Keywords:

PAH AhR ARNT AhRR CYP1A1 apotosis estradiol secretion ovarian follicles

Descriptors:

  • NZ7_2: Environment and health risks

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Gregoraszczuk 

Number of co-investigators in the project: 5

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 761 600 PLN

Project start date (Y-m-d): 2016-02-16

Project end date (Y-m-d): 2019-11-15

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora laminarna klasy II (Biohazard) (45 000 PLN)
  2. komputer z urządzeniem wielofunkcyjnym (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Compounds of PAH mixtures dependent interaction between multiple signaling pathways in granulosa tumour cells.
    Authors:
    K Zajda, A Rak, A Ptak, EL Gregoraszczuk
    Academic press:
    Toxicology Letters (rok: 2019, tom: 80, strony: 101-104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Environmental polycyclic aromatic hydrocarbons mixture, in human blood levels, decreased estradiol secretion by granulosa cells via ESR1 and GPER1 but not ESR2 receptor.
    Authors:
    K Zajda, EL Gregoraszczuk
    Academic press:
    Human &Experimental Toxicology (rok: 2020, tom: 39, strony: 276-289), Wydawca: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/0960327119886027 - link to the publication
  3. Composition dependent mechanisms of PAH mixtures action as tumor promotor and progressor in non-cancer and cancer ovarian granulosa cells.
    Authors:
    Karolina Zajda, Ewa L Gregoraszczuk
    Academic press:
    Organohalogen Compounds (rok: 2018, tom: 80, strony: 101-104), Wydawca: Dioxin Symposia
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa nontumor and granulosa tumor cell lines
    Authors:
    Karolina Zajda, Anna Ptak, Agnieszka Rak, Elżbieta Fiedor, Adam Grochowalski, Tomasz Milewicz, Ewa L. Gregoraszczuk
    Academic press:
    Toxicology (rok: 2017, tom: 389, strony: 45303), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tox.2017.07.003 - link to the publication

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