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Preclinical studies on the role of glutathione stabilized gold nanoparticles conjugated to doxorubicin on feline injection-site sarcomas - mechanism of action, efficacy studies and proteome analyses

2015/17/D/NZ5/04241

Keywords

Descriptors

  • NZ5_8: Leczenie chorób zwierząt
  • NZ4_5: Patomorfologia
  • NZ5_9: Inne zagadnienia pokrewne

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Medycyny Weterynaryjnej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Katarzyna Agnieszka Zabielska-Koczywąs

Number of co-investigators in the project: 3

Call

SONATA 9 – announced on 2015-03-16

Amount awarded
456 226 PLN
Project start date
2016-02-24
Project end date
2019-02-23
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Przenośnyautomatyczny licznik komórek "Scepter". Cost: 15 000 PLN
  2. homogenizator. Cost: 15 190 PLN
  3. laptop. Cost: 7 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Current knowledge on feline injection-site sarcoma treatment

    Authors:
    Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Roman Lechowski
    Academic press:
    Acta Veterinaria Scandinavica (year: 2017, volume: 59, pages: 47), Publisher: BioMedCentral
    Status:
    Published
    DOI:
    10.1186/s13028-017-0315-y – link to the publication

  2. Proteomic differences in feline fibrosarcomas grown using doxorubicin-sensitive and –resistant cell lines on the chick embryo model

    Authors:
    Zabielska-Koczywąs Katarzyna, Michalak Katarzyna, Wojtalewicz Anna, Winiarczyk Mateusz, Adaszek Łukasz, Winiarczyk Stanisław, Lechowski Roman
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 19(2), pages: 576), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19020576 – link to the publication

  3. Distribution of glutathione-stabilized gold nanoparticles and their role as a drug delivery system for doxorubicin in feline fibrosarcomas – preclinical studies in a murine model

    Authors:
    Zabielska-Koczywąs Katarzyna, Wojtalewicz Anna, Użarowska Ewelina, Klejman Agata, Wojtkowska Agata, Dolka Izabella, Wojnicki Marek, Sobczak Katarzyna, Wójcik Michał., Shen Haifa, Ferrari Mauro, Lechowski Roman
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 19(4), pages: pii: E1021), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19041021 – link to the publication

  4. The Use of Liposomes and Nanoparticles as Drug Delivery Systems to Improve Cancer Treatment in Dogs and Cats

    Authors:
    Katarzyna Zabielska-Koczywąs, Roman Lechowski
    Academic press:
    Molecules (year: 2017, volume: 22, pages: 2167), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22122167 – link to the publication

Articles in post-conference publications (2)

  1. The influence of doxorubicin conjugated to gold nanoparticles on kidney and liver of nude mice with feline injection-site sarcomas

    Authors:
    Zabielska-Koczywąs Katarzyna, Wojtalewicz Anna, Użarowska Ewelina, Klejman Agata, Dolka Izabela, Wójcik Michał, Mieczkowski Józef, Lechowski Roman
    Conference:
    ESVONC-ESVCP Congress 2016 (year: 2017, pages: E3), Publisher: John Wiley and Sons Ltd
    Date:
    conference 20-22.10.2016
    Status:
    Published

  2. The influence of doxorubicin conjugated to gold nanoparticles on kidney and liver of nude mice with feline injection-site sarcomas

    Authors:
    Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Ewelina Użarowska, Agata Klejman, Wiktor Lewandowski, Michał Wójcik, Stanisław Mieczkowski, Roman Lechowski
    Conference:
    ESVONC-ESVCP Congress 2016 (year: 2016, pages: 207), Publisher: TMS Events
    Date:
    conference 20-22.10.2016
    Status:
    Published

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