Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Preclinical studies on the role of glutathione stabilized gold nanoparticles conjugated to doxorubicin on feline injection-site sarcomas - mechanism of action, efficacy studies and proteome analyses

2015/17/D/NZ5/04241

Keywords:

gold nanoparticles doxorubicin injection-site sarcoma immunodeficient mice imaging

Descriptors:

  • NZ5_8: Animal disease treatment
  • NZ4_5: Anatomical pathology
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Medycyny Weterynaryjnej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Zabielska-Koczywąs 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 456 226 PLN

Project start date (Y-m-d): 2016-02-24

Project end date (Y-m-d): 2019-02-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. laptop (7 000 PLN)
  2. homogenizator (15 190 PLN)
  3. Przenośnyautomatyczny licznik komórek "Scepter" (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Current knowledge on feline injection-site sarcoma treatment
    Authors:
    Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Roman Lechowski
    Academic press:
    Acta Veterinaria Scandinavica (rok: 2017, tom: 59, strony: 47), Wydawca: BioMedCentral
    Status:
    Published
    DOI:
    10.1186/s13028-017-0315-y - link to the publication
  2. The Use of Liposomes and Nanoparticles as Drug Delivery Systems to Improve Cancer Treatment in Dogs and Cats
    Authors:
    Katarzyna Zabielska-Koczywąs, Roman Lechowski
    Academic press:
    Molecules (rok: 2017, tom: 22, strony: 2167), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22122167 - link to the publication
  3. Distribution of glutathione-stabilized gold nanoparticles and their role as a drug delivery system for doxorubicin in feline fibrosarcomas – preclinical studies in a murine model
    Authors:
    Zabielska-Koczywąs Katarzyna, Wojtalewicz Anna, Użarowska Ewelina, Klejman Agata, Wojtkowska Agata, Dolka Izabella, Wojnicki Marek, Sobczak Katarzyna, Wójcik Michał., Shen Haifa, Ferrari Mauro, Lechowski Roman
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19(4), strony: pii: E1021), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19041021 - link to the publication
  4. Proteomic differences in feline fibrosarcomas grown using doxorubicin-sensitive and –resistant cell lines on the chick embryo model
    Authors:
    Zabielska-Koczywąs Katarzyna, Michalak Katarzyna, Wojtalewicz Anna, Winiarczyk Mateusz, Adaszek Łukasz, Winiarczyk Stanisław, Lechowski Roman
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19(2), strony: 576), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19020576 - link to the publication
  1. The influence of doxorubicin conjugated to gold nanoparticles on kidney and liver of nude mice with feline injection-site sarcomas
    Authors:
    Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Ewelina Użarowska, Agata Klejman, Wiktor Lewandowski, Michał Wójcik, Stanisław Mieczkowski, Roman Lechowski
    Conference:
    ESVONC-ESVCP Congress 2016 (rok: 2016, ), Wydawca: TMS Events
    Data:
    konferencja 20-22.10.2016
    Status:
    Published
  2. The influence of doxorubicin conjugated to gold nanoparticles on kidney and liver of nude mice with feline injection-site sarcomas
    Authors:
    Zabielska-Koczywąs Katarzyna, Wojtalewicz Anna, Użarowska Ewelina, Klejman Agata, Dolka Izabela, Wójcik Michał, Mieczkowski Józef, Lechowski Roman
    Conference:
    ESVONC-ESVCP Congress 2016 (rok: 2017, ), Wydawca: John Wiley and Sons Ltd
    Data:
    konferencja 20-22.10.2016
    Status:
    Published

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