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Information on the principal investigator and host institution

Information of the project and the call

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Effects and potential mechanisms of action of dislufiram and nepicastat in morphine dependence in laboratory animal

2014/15/D/NZ7/01821

Keywords:

disulfiram morphine drug dependence tolerance

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Patrycja Kleczkowska 

Number of co-investigators in the project: 5

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 616 785 PLN

Project start date (Y-m-d): 2015-09-17

Project end date (Y-m-d): 2018-09-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. DISULFIRAM ATTENUATES MORPHINE OR METHADONE WITHDRAWAL SYNDROME IN MICE
    Authors:
    de Corde A., Krząścik P, Wolińska R., Kleczkowska P., Filip M., Bujalska-Zadrozny M.
    Academic press:
    Behavioural Pharmacology (rok: 2018, tom: 29, strony: 393-399), Wydawca: Wolters Kluwer Health Inc.
    Status:
    Published
    DOI:
    10.1097/FBP.0000000000000376. - link to the publication
  2. Treatment with dopamine -hydroxylase (DBH) inhibitors prevents morphine use and relapse in rats
    Authors:
    Frankowska M, Surówka P, Suder A, Pieniążek R, Filip M, Pukło R, Jastrzębska J, Daniel WA, Zadrożny-Bujalska M, Kleczkowska P
    Academic press:
    Pharmacological Reports (rok: 2021, tom: 1, strony: 45309), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00307-2 - link to the publication
  3. Advantages and disadvantages of disulfiram coadministered with popular addictive substances
    Authors:
    Patrycja Kleczkowska, Dorota Sulejczak, Małgorzata Zaremba
    Academic press:
    European Journal of Pharmacology (rok: 2021, tom: 8, strony: 17), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2021.174143 - link to the publication
  4. The Positive and Negative Outcome of Morphine and Disulfiram Subacute Co-Administration in Rats in the Absence of Ethanol Challeng
    Authors:
    Fraczek K, Kowalczyk A, Kasarello K, Sygitowicz G, Sulejczak D, Zaremba , Konop M, Frankowska M, Filip M, Bujalska-Zadrozny M, Kleczkowska P
    Academic press:
    Pharmaceutics (rok: 2021, tom: 29, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13010029 - link to the publication
  1. Chronic disulfiram treatment increases analgesia and reduces tolerance induced by morphine but with increased toxic effects
    Authors:
    Kleczkowska P., Pekala M., Pawlik K., Sulejczak D., Kowalczyk A., Sygitowicz G., Frankowska M., Konop M., Filip M., Rudnicka L., Bujalska-Zadrozny M
    Conference:
    5th Annual International Conference on Pharmaceutical Sciences (rok: 2018, ), Wydawca: The Athens Institute for Education and Research
    Data:
    konferencja 7-10 Maj
    Status:
    Published
  2. The effects of disulfiram on morphine self-administration and reinstatement of seeking behavior in rats
    Authors:
    Frankowska M., Kleczkowska P., Suder A., Kluska K., Bujalska-Zadrożny M., Filip M.
    Conference:
    6th Mediterranean Neuroscience Society Conference (rok: 2017, ), Wydawca: The Mediterranean Neuroscience Society (MNS)
    Data:
    konferencja Czerwiec 12-15
    Status:
    Published
  3. Repeated daily administration of disulfiram and morphine combination - what are the consequences?
    Authors:
    Kleczkowska P., Pawlik K., Pekala M., Frankowska M., Kowalczyk A., Sygitowicz G., Sulejczak D., Konop M., Filip M., Rudnicka L., Bujalska-Zadrozny M.
    Conference:
    XI Copernican International Young Scientists Conference (rok: 2017, ), Wydawca: Nicolaus Copernicus University of Toruń
    Data:
    konferencja 28-30 czerwiec
    Status:
    Published
  4. Repeated daily administration of disulfiram and morphine combination - what are the consequences?
    Authors:
    KleczkowskaP., Pekala M., Pawlik K., Frankowska M., Kowalczyk A., Sygitowicz G., Sulejczak D., Konop M., Filip M., Rudnicka L., Bujalska-Zadrozny M.
    Conference:
    International Conference on Pharmaceutical Drugs (rok: 2017, ), Wydawca: Gavin Conferences and Publishers Inc.
    Data:
    konferencja Maj 15-17
    Status:
    Published

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