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Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resistant depression

2015/17/B/NZ7/02979

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Mariusz Papp

Number of co-investigators in the project: 7

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
716 664 PLN
Project start date
2016-02-26
Project end date
2019-02-25
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stolik stereotaktyczny z oprzyrządowaniem. Cost: 25 745 PLN
  2. Stymulator wielokanałowy i Konwerter cyfrowo-analogowy. Cost: 33 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. GENOMIC SCREENING OF WISTAR AND WISTAR-KYOTO RATS EXPOSED TO CHRONIC MILD STRESS AND DEEP BRAIN STIMULATION OF THE PREFRONTAL CORTEX

    Authors:
    Mariusz Papp, Piotr Gruca, Agata Faron-Górecka, Maciej Kusmider and Paul Willner
    Academic press:
    Neuroscience 423 (2019) 66–75 (year: 2019, volume: 423, pages: 66–75), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2019.10.015 – link to the publication

  2. RAPID ANTIDEPRESSANT EFFECTS OF DEEP BRAIN STIMULATION OF THE PRE-FRONTAL CORTEX IN AN ANIMAL MODEL OF TREATMENT-RESISTANT DEPRESSION

    Authors:
    Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Katarzyna Tota-Glowczyk, Monika Niemczyk and Paul Willner
    Academic press:
    Journal of Psychopharmacology (year: 2018, volume: 32, pages: 1133-1140), Publisher: SAGE Publishing
    Status:
    Published
    DOI:
    10.1177/0269881118791737 – link to the publication

  3. VALIDATION OF CHRONIC MILD STRESS IN THE WISTAR-KYOTO RAT AS AN ANIMAL MODEL OF TREATMENT-RESISTANT DEPRESSION

    Authors:
    Paul Willner, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Katarzyna Tota-Glowczyk, Monika Niemczyk and Mariusz Papp
    Academic press:
    Behavioural Pharmacology (year: 2019, volume: 30, pages: 239-250), Publisher: Lippincott Williams & Wilkins
    Status:
    Published
    DOI:
    10.1097/FBP.0000000000000431 – link to the publication

  4. MOLEKULARNE MARKERY ODPOWIEDZI NA STRES W DWÓCH MODELACH DEPRESJI LEKOOPORNEJ U SZCZURÓW

    Authors:
    Agata Faron-Górecka, Maciej Kusmider, Mariusz Papp
    Academic press:
    Strona popularnonaukowa IF PAN (year: 2018, volume: nie dotyczy, pages: nie dotyczy), Publisher: Instytut Farmakologii PAN w Krakowie
    Status:
    Published
    DOI:
    link to the publication

Articles in post-conference publications (4)

  1. Changes in genes expression correlate with stress and deep brain stimulation in two strains of rats.

    Authors:
    Kuśmider M, Faron-Górecka A, Dziedzicka-Wasylewska M, Papp M
    Conference:
    Workshop: Cognitive affective biases - from mechanisms to disease symptoms (year: 2019, pages: 1311), Publisher: Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Date:
    conference 13 - 17 maj
    Status:
    Published

  2. Effects of deep brain stimulation of the medial prefrontal cortex in two animal models of treatment-resistant depression.

    Authors:
    Gruca P, Papp M, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P
    Conference:
    30th Congress of the European College of Neuropsychopharmacology (ECNP), Paris 2017 (year: 2017, pages: S770), Publisher: Elsevier
    Date:
    conference 2 - 5 września
    Status:
    Published

  3. Antidepressant efficacy of Deep Brain Stimulation in Wistar Kyoto rats exposed to Chronic Mild Stress: an animal model of treatment-resistant depression

    Authors:
    Gruca P, Papp M, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P
    Conference:
    31st Congress of the European College of Neuropsychopharmacology (ECNP) (year: 2018, pages: P.813), Publisher: Elsevier
    Date:
    conference 6 - 9 październik
    Status:
    Published

  4. Brain Stimulation of the medial prefrontal cortex has anxiolytic and pro-cognitive effects in two animal models of treatment-resistant depression in rats

    Authors:
    Papp M, Gruca P, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P.
    Conference:
    17th Biennial Meeting of the European Behavioural Pharmacology Society (year: 2017, pages: A63), Publisher: Lippincott Williams & Wilkins
    Date:
    conference 31 sierpnia - 3 września
    Status:
    Published

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