Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resistant depression

2015/17/B/NZ7/02979

Keywords:

Deep brain stimulation antidepressant drugs treatment-resistant depression animal models Wistar rats Wistar-Kyoto rats chronic stress anhedonia cognitive impairment stress hormones BDNF glutamate receptors gene expression protein levels gene screening

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Papp 

Number of co-investigators in the project: 7

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 716 664 PLN

Project start date (Y-m-d): 2016-02-26

Project end date (Y-m-d): 2019-02-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stolik stereotaktyczny z oprzyrządowaniem (25 745 PLN)
  2. Stymulator wielokanałowy i Konwerter cyfrowo-analogowy (33 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. GENOMIC SCREENING OF WISTAR AND WISTAR-KYOTO RATS EXPOSED TO CHRONIC MILD STRESS AND DEEP BRAIN STIMULATION OF THE PREFRONTAL CORTEX
    Authors:
    Mariusz Papp, Piotr Gruca, Agata Faron-Górecka, Maciej Kusmider and Paul Willner
    Academic press:
    Neuroscience 423 (2019) 66–75 (rok: 2019, tom: 423, strony: 66–75), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.015 - link to the publication
  2. RAPID ANTIDEPRESSANT EFFECTS OF DEEP BRAIN STIMULATION OF THE PRE-FRONTAL CORTEX IN AN ANIMAL MODEL OF TREATMENT-RESISTANT DEPRESSION
    Authors:
    Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Katarzyna Tota-Glowczyk, Monika Niemczyk and Paul Willner
    Academic press:
    Journal of Psychopharmacology (rok: 2018, tom: 32, strony: 1133-1140), Wydawca: SAGE Publishing
    Status:
    Published
    DOI:
    10.1177/0269881118791737 - link to the publication
  1. Brain Stimulation of the medial prefrontal cortex has anxiolytic and pro-cognitive effects in two animal models of treatment-resistant depression in rats
    Authors:
    Papp M, Gruca P, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P.
    Conference:
    17th Biennial Meeting of the European Behavioural Pharmacology Society (rok: 2017, ), Wydawca: Lippincott Williams & Wilkins
    Data:
    konferencja 31 sierpnia - 3 września
    Status:
    Published
  2. Brain Stimulation of the medial prefrontal cortex has anxiolytic and pro-cognitive effects in two animal models of treatment-resistant depression in rats
    Authors:
    Papp M, Gruca P, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P.
    Conference:
    17th Biennial Meeting of the European Behavioural Pharmacology Society (), Wydawca: Lippincott Williams & Wilkins
    Data:
    konferencja 31 sierpnia - 3 września
    Status:
    Published
  3. Antidepressant efficacy of Deep Brain Stimulation in Wistar Kyoto rats exposed to Chronic Mild Stress: an animal model of treatment-resistant depression
    Authors:
    Gruca P, Papp M, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P
    Conference:
    31st Congress of the European College of Neuropsychopharmacology (ECNP) (rok: 2018, ), Wydawca: Elsevier
    Data:
    konferencja 6 - 9 październik
    Status:
    Published
  4. Changes in genes expression correlate with stress and deep brain stimulation in two strains of rats.
    Authors:
    Kuśmider M, Faron-Górecka A, Dziedzicka-Wasylewska M, Papp M
    Conference:
    Workshop: Cognitive affective biases - from mechanisms to disease symptoms (rok: 2019, ), Wydawca: Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Data:
    konferencja 13 - 17 maj
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy