Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New mechanism of bisphenol A and its analogs action in the biology of ovarian cancer.

2013/09/B/NZ7/00405

Keywords:

BPA TBBPA TCBPA Adipokines PPARgamma ERalfa ERbeta Ovarian cancer cells

Descriptors:

  • NZ7_2: Environment and health risks
  • NZ3_1: Cell biology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Ptak 

Number of co-investigators in the project: 4

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 536 000 PLN

Project start date (Y-m-d): 2014-03-21

Project end date (Y-m-d): 2017-03-20

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Spektrofotometr do pomiaru mikroobjętości NanoDrop 2000 z opragramowaniem (62 000 PLN)
  2. Komputer z drukarką (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  • Book publications / chapters in book publications (1)
  1. Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors
    Authors:
    Marta Hoffmann, Justyna Gogola, Anna Ptak
    Academic press:
    Hormones and Cancer (rok: 2018, tom: 9, strony: 166-174), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12672-018-0331-z - link to the publication
  2. Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism
    Authors:
    Marta Hoffmann, Elzbieta Fiedor, Anna Ptak
    Academic press:
    Toxicology Letters (rok: 2017, tom: 269, strony: 15-22), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2017.01.006 - link to the publication
  3. Bisphenol A and its derivatives decrease expression of chemerin, which reverses its stimulatory action in ovarian cancer cells
    Authors:
    Marta Hoffmann, Agnieszka Rak, Anna Ptak
    Academic press:
    Toxicology Letters (rok: 2018, tom: 291, strony: 61-69), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2018.04.004 - link to the publication
  4. Stimulation of ovarian cell proliferation by tetrabromobisphenol A but not tetrachlorobisphenol A through G protein-coupled receptor 30
    Authors:
    Marta Hoffmann, Justyna Gogola, Małgorzata Kotula-Balak, Anna Ptak
    Academic press:
    Toxicology in vitro (rok: 2017, tom: 54, strony: 54-59), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2017.08.009 - link to the publication
  1. ADIPOKINES SECRETED BY HUMAN OVARIAN CANCER CELLS PLAY AN IMPORTANT ROLE IN CANCER PROGRESSION BY INDUCTION CELLS PROLIFERATION.
    Authors:
    K. Kulczak, E. Fiedor, W. Natkaniec, A. Rak, A. Ptak
    Conference:
    19th International Meeting of the European Society of Gynaecological Oncology (ESGO 2015) (rok: 2015, ), Wydawca: Wolters Kluwer
    Data:
    konferencja 24-27 październik
    Status:
    Published
    DOI:
    link to the publication
  2. Bisphenol A and its halogenated derivatives induce apelin expression which acts as mitogenic factor in human epithelial ovarian cancer cell.
    Authors:
    Marta Hoffmann, Elzbieta Fiedor, Anna Ptak
    Conference:
    36th International Symposium on Halogenated Persistent Organic Pollutants. DIOXIN 2016 (rok: 2016, ), Wydawca: Organohalogen Compounds
    Data:
    konferencja 28 sierpień - 2 wrzesień 2016
    Status:
    Published
  1. The ovary as a target organ for bisphenol A toxicity.
    Authors:
    Anna Ptak, Marta Hoffmann, Agnieszka Rak
    Book:
    Bisphenol A (BPA) Exposure and Health Risks (rok: 2017, tom: 1, strony: 57-73), Wydawca: InTech
    Status:
    Published

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