Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of chemokines in the pathogenesis of depression and molecular mechanism of action of antidepressants.

2013/09/B/NZ7/04096

Keywords:

depression antidepressant drugs chemokines

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ3_6: Cell neurobiology
  • NZ4_9: Systems neurobiology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Basta-Kaim 

Number of co-investigators in the project: 8

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 698 602 PLN

Project start date (Y-m-d): 2014-04-07

Project end date (Y-m-d): 2017-04-06

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Homogenizator komorkowy z adapterem (39 000 PLN)
  2. wirówka (31 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (18)
  1. Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway.
    Authors:
    Trojan E, Chamera K, Bryniarska N, Kotarska K, Leśkiewicz M, Regulska M, Basta-Kaim A.
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 4, strony: 45307), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1458-1 - link to the publication
  2. Prenatal stress affects viability, activation, and chemokine signaling in astroglial cultures
    Authors:
    Sowa J, Slusarczyk J, Trojan E, Chamera K, Leskiewicz M, Regulska M, Kotarska K, Basta-Kaim A
    Academic press:
    Journal of Neuroimmunology (rok: 2017, tom: 311, strony: 79-87), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2017.08.006 - link to the publication
  3. Beneficial impact of intracerebroventricular fractalkine administration on behavioral and biochemical changes induced by prenatal stress in adult rats: Possible role of NLRP3 inflammasome pathway.
    Authors:
    Ślusarczyk J, Trojan E, Wydra K, Głombik K, Chamera K, Kucharczyk M, Budziszewska B, Kubera M, Lasoń W, Filip M, Basta-Kaim A.
    Academic press:
    Biochem Pharmacol. (rok: 2016, tom: 1;113, strony: 45-56), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2016.05.008. - link to the publication
  4. Errata do: Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway
    Authors:
    Trojan E, Chamera K, Bryniarska N, Kotarska K, Leśkiewicz M, Regulska M, Basta-Kaim A.
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 4, strony: 1), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-019-1534-1 - link to the publication
  5. The Modulatory Properties of Chronic Antidepressant Drugs Treatment on the Brain Chemokine - Chemokine Receptor Network: A Molecular Study in an Animal Model of Depression.
    Authors:
    Trojan E, Śluarczyk J, Chamera K, Kotarska K, Głombik K, Kubera M, Basta-Kaim A
    Academic press:
    Frontiers in Pharmacology (rok: 2017, tom: 8, strony: 779), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2017.00779. - link to the publication
  6. Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells.
    Authors:
    Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Bogusława Budziszewska, Marta Kubera, Władysław Lasoń, Katarzyna Popiołek-Barczyk, Joanna Mika, Krzysztof Wędzony, Agnieszka Basta-Kaim
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2015, tom: 9, strony: 45305), Wydawca: Frontiers in Cellular Neuroscience
    Status:
    Published
    DOI:
    10.3389/fncel.2015.00082 - link to the publication
  7. A Potential Contribution of Chemokine Network Dysfunction to the Depressive Disorders.
    Authors:
    Ślusarczyk J, Trojan E, Chwastek J, Głombik K, Basta-Kaim A.
    Academic press:
    Curr Neuropharmacol. 2016; (rok: 2016, tom: 14(7), strony: 705-20), Wydawca: Betham Science
    Status:
    Published
    DOI:
    brak - link to the publication
  8. Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures
    Authors:
    Ślusarczyk J, Trojan E, Głombik K, Piotrowska A, Budziszewska B, Kubera M, Popiołek-Barczyk K, Lasoń W, Mika J, Basta-Kaim A1.
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 18, strony: 23), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19071965 - link to the publication
  1. Emerging role of chronic fluoxetine administration on the fraktalkine signaling in the brain of adult prenatally stressed animals
    Authors:
    Ewa Trojan, Joanna Ślusarczyk, Katarzyna Głombik, Katarzyna Chamera
    Conference:
    Neuronus IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 22-24.04.2016
    Status:
    Published
  2. Prenatal stress leads to inflammatory activation in the adult rat brain - the role of microglia cells,
    Authors:
    Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Agnieszka Basta-Kaim
    Conference:
    9th World Congress - International Brain Research Organization - IBRO (rok: 2015, ), Wydawca: Abstarct Book
    Data:
    konferencja 7-11.07.2015
    Status:
    Published
  3. Prenatal stress procedure elevated the pro-inflammatory Monocyte Chemoattractant Protein (MCP-1/CCL2) and CCR2 receptor expression in brain of adult rats: a link to depression.
    Authors:
    Agnieszka Basta-Kaim, Bogusława Budziszewska, Marta Kubera, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Katarzyna Curzytek, Monika Leśkiewicz, Joanna Sowa
    Conference:
    Mediterranean Neuroscience Society - 5th Meeting 2015 (rok: 2015, ), Wydawca: Abstract Book
    Data:
    konferencja 12-15.06.2015
    Status:
    Published
  4. Emerging role of the neuron-microglia communication in the pathomechanism of depression
    Authors:
    Joanna Ślusarczyk, Ewa Trojan, Katarzyna Chamera, Katarzyna Głombik, Agnieszka Basta-Kaim
    Conference:
    XXX Ogólnopolskie Seminarium "Mechanizmy służące utrzymaniu życia i regulacji fizjologicznych" (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 25.06.2016
    Status:
    Published
  5. Exogenous fraktalkine administration modifies behavioral disturbances induced by prenatal stress in adult rats
    Authors:
    Joanna Ślusarczyk, Ewa Trojan, Karolina Wydra, Katarzyna Głombik, Katarzyna Chamera, Małgorzata Filip, Agnieszka Basta-Kaim
    Conference:
    10th FENS Forum of Neuroscience (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 2-6.07.2016
    Status:
    Published
  6. Exogenous fraktalkine treatment modulates the expression of proinflammatory factors in the hippocampus of adult, prenatally stressed rats
    Authors:
    Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Katarzyna Chamera, Agnieszka Basta-Kaim
    Conference:
    22nd Scientific Conference of Society on NeuroImmune Pharmacology (SNIP) (rok: 2016, ), Wydawca: SNIP, Springer
    Data:
    konferencja 6-9.04.2016
    Status:
    Published
  7. The beneficial action of antidepressant drugs on the chemokine CCL2/CCR2 brain communication: study in an animal model of depression
    Authors:
    Agnieszka Basta-Kaim, Monika Leśkiewicz, Ewa Trojan, Bogusława Budziszewska, Joanna Ślusarczyk, Katarzyna Głombik, Katarzyna Chamera, Magdalena Regulska
    Conference:
    10th FENS Forum of Neuroscience (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 2-6.07.2016
    Status:
    Published
  8. The influence of chronic venlafaxine administration on the chemokine CXCL12 concentration in the brain of adult offspring rats - study in the animal model of depression
    Authors:
    Katarzyna Chamera, Ewa Trojan, Joanna Ślusarczyk, Katarzyna Głombik, Agnieszka Basta-Kaim
    Conference:
    22nd Scientific Conference of Society on NeuroImmune Pharmacology (SNIP) (rok: 2016, ), Wydawca: SNIP, Springer
    Data:
    konferencja 6-9.04.2016
    Status:
    Published
  9. Emerging role of fractalkine in the modulation of phagocytic activity of microglia cells
    Authors:
    Agnieszka Basta-Kaim, Bogusława Budziszewska, Joanna Ślusarczyk, Marta Kubera, Ewa Trojan, Katarzyna Chamera, Katarzyna Głombik, Monika Leśkiewicz
    Conference:
    Cell Symposia: 100 Years of Phagocytes (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 19-22.09.2016
    Status:
    Published
  10. Ocena wpływu stresu prenatalnego na poziom fraktalkiny w aktywowanych lipopolisacharydem hodowlach organotypowych hipokampa
    Authors:
    Katarzyna Chamera, Ewa Trojan, Joanna Ślusarczyk, Agnieszka Basta-Kaim
    Conference:
    IX Interdyscyplinarna Konferencja Naukowa TYGIEL 2017 "Interdyscyplinarność kluczem do rozwoju" (rok: 2017, ), Wydawca: Abstract Book
    Data:
    konferencja 18-19.03.2017
    Status:
    Published
  11. Prenatal stress leads to prolonged microglial activation in the hippocampus and frontal cortex of male rats
    Authors:
    Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Agnieszka Basta-Kaim
    Conference:
    European Neuroscience Conference by Doctoral Students for Doctoral Students (rok: 2015, ), Wydawca: Wystąpienie ustne
    Data:
    konferencja 23-26.04.2015
    Status:
    Published
  12. The impact of prenatal stress on the viability and activation of astrocytes in prmary cultures
    Authors:
    Joanna Ewa Sowa, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Chamera, Agnieszka Basta-Kaim
    Conference:
    Neuronus IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 22-24.04.2016
    Status:
    Published
  13. Prenatal stress leads to microglial activation in the brains of male rats - the role of fractalkine signaling.
    Authors:
    Joanna Ślusarczyk, Ewa Trojan, Ewa Szczesny, Katarzyna Głombik, Agnieszka Basta-Kaim
    Conference:
    XXIX Ogólnopolskie Seminarium "Mechanizmy służące utrzymaniu życia i regulacji fizjologicznych" (rok: 2015, ), Wydawca: Abstract Book
    Data:
    konferencja 20.06.2015
    Status:
    Published
  14. The favorable impact of tianeptine on the evoked by prenatal stress dysregulation of chemokine-chemokine receptor axis in brain of adult offspring rats
    Authors:
    Agnieszka Basta-Kaim, Bogusława Budziszewska, Ewa Trojan, Joanna Ślusarczyk, Katarzyna Chamera, Katarzyna Głombik, Katarzyna Kotarska
    Conference:
    6th Mediterranean Neuroscience Society Conference 2017 (MNS2017) (rok: 2017, ), Wydawca: Abstract Book
    Data:
    konferencja 12-15.06.2017
    Status:
    Published
  15. Up-regulation of inflammatory factors in the hippocampus and frontal cortex of young prenatally stressed rats
    Authors:
    Katarzyna Chamera, Ewa Trojan, Joanna Ślusarczyk, Katarzyna Głombik, Agnieszka Basta-Kaim
    Conference:
    2nd Central European Biomedical Congress "From emerging biochemical strategies to personalized medicine" (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 15-18.06.2016
    Status:
    Published
  16. A new potential mechanism of action of tianeptine - the effect on microglia cell activation
    Authors:
    Joanna Slusarczyk, Ewa Trojan, Anna Piotrowska, Katarzyna Głombik, Joanna Mika, Agnieszka Basta-Kaim
    Conference:
    European Society for Neurochemistry Biannual Conference: Molecular Mechanisms of Regulation in the Nervous System (rok: 2015, ), Wydawca: SpringerPlus
    Data:
    konferencja 14-17.06.2015
    Status:
    Published
  17. The effect of tianeptine on prenatal stress impaired SDF-1/CXCL12 protein expression in the brain of adult offspring rats: a link to depression.
    Authors:
    Katarzyna Głombik, Ewa Trojan, Joanna Ślusarczyk, Agnieszka Basta-Kaim
    Conference:
    7th EFIS-EJI South East European Immunology School (SEEIS2015) (rok: 2015, ), Wydawca: Abstarct Book
    Data:
    konferencja 16-19.10.2015
    Status:
    Published
  18. The influence of antidepressant drugs on chemokine CCL2 and its receptors (CCR1 and CCR2) communication in adult offspring rats. Study in an animal model of depression.
    Authors:
    Ewa Trojan, Agnieszka Basta-Kaim, Joanna Ślusarczyk, Katarzyna Głombik, Joanna Sowa
    Conference:
    Federation of European Neuroscience Societies - FENS, Regional Meeting 2015 (rok: 2015, ), Wydawca: Abstarct Book
    Data:
    konferencja 7-10.10.2015
    Status:
    Published

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