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Information on the principal investigator and host institution

Information of the project and the call

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Involvement of estrogen receptors, aromatic hydrocarbons receptors and PPAR gamma receptors in the mechanism of endocrine disruptors action in mouse neurons.

2012/07/B/NZ4/00238

Keywords:

xenoestrogens estrogen receptors aromatase neurons phthalates dietyloheksyl phthalate (DEHP) dibutyl phthalate (DBP) AhR PPAR gamma apoptosis cytotoxicity ROS

Descriptors:

  • NZ4_2: Physiology
  • NZ4_6: Endocrinology
  • NZ4_8: Neuroendocrinology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Hodowli i Biologii Zwierząt

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Wójtowicz 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 332 136 PLN

Project start date (Y-m-d): 2013-07-05

Project end date (Y-m-d): 2016-07-04

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (5)
  1. The action of di-(2-ethylhexyl) phthalate (DEHP) in mouse cerebral cells involves an impairment in aryl hydrocarbon receptor (AhR) signaling
    Authors:
    Anna K. Wojtowicz, Agnieszka M. Sitarz, Małgorzata Szczęsna, Konrad A. Szychowski
    Academic press:
    Neurotoxicity Research , Wydawca: Springer
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Dibutyl phthalate (DBP)-induced apoptosis and neurotoxicity are mediated via the aryl hydrocarbon receptor (AhR) but not by estrogen receptor alpha (ER alfa), estrogen receptor beta (ER beta) or peroxisome proliferator-activated receptor gamma (PPAR gamma) in mouse cortical neurons.
    Authors:
    Anna K. Wójtowicz, Konrad A. Szychowski, Agnieszka Wnuk, Małgorzata Kajta
    Academic press:
    Neurotoxicity Research (rok: 2017, tom: 31, strony: 77-89), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-016-9665-x - link to the publication
  1. The impact of di-(2-ethylhexyl) phtalate (DEHP) on cytotoxicity and cell metabolism in mouse astrocytes in vitro
    Authors:
    Sitarz A.M., Szychowski K.A. Wojtowicz A.K.
    Conference:
    8th Copenhagen Workshop on Endocrine Disrupters (rok: 2015, ), Wydawca: Copenhagen Workshop on Endocrine Disrupters
    Data:
    konferencja 27-30 Kwiecień
    Status:
    Published
  2. Wpływ wyciszenia receptora dla węglowodorów arylowych (AhR) na proces apoptozy w neuronach kory mózgowej myszy [Impact of silencing siRNA on aryl hydrocarbon receptor (AhR) on apoptotic process in mouse cortical neurons]
    Authors:
    Szychowski K.A., Sitarz A.M., Wójtowicz A.K.
    Conference:
    Molecular Research in Animal Science (rok: 2014, ), Wydawca: Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie
    Data:
    konferencja 09-10.06
    Status:
    Published
  3. The effect of MEHP on viability and apoptosis in mouse cortical neurons in vitro
    Authors:
    Agnieszka M. Sitarz, Konrad A. Szychowski, Anna K. Wójtowicz
    Conference:
    NEURONUS 2015 IBRO&IRUN Neuroscience Forum (rok: 2015, ), Wydawca: IBRO&IRUN Neuroscience Forum
    Data:
    konferencja 17-19.04
    Status:
    Published
  4. The impact of di-(2-ethylhexyl) phthalate (DEHP) on PPAR-gamma, MMP-2 and MMP-9 expression in mouse astrocytes and cortical neurons in vitro
    Authors:
    Sitarz A.M., Szychowski K.A., Wójtowicz A.K.
    Conference:
    Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics (rok: 2015, ), Wydawca: Instytut Medycyny Doświadczalnej i Klinicznej PAN
    Data:
    konferencja 22-23 października
    Status:
    Published
  5. The effect of DEHP on viability and apoptosis in mouse hippocampal neuron cells
    Authors:
    Sitarz A.M., Szychowski K.A., Wójtowicz A.K.
    Conference:
    NEURONUS 2014 IBRO&IRUN Neuroscience Forum (rok: 2014, ), Wydawca: IBRO&IRUN Neuroscience Forum
    Data:
    konferencja 25-27.04
    Status:
    Published
    DOI:
    link to the publication

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