Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of mechanism of action of selected bisphenols on human erythrocytes and mononuclear peripheral blood cells

2012/07/B/NZ7/01174

Keywords:

bisphenols erythrocytes mononuclear blood cells toxicity

Descriptors:

  • NZ7_2: Environment and health risks
  • NZ7_15: Toxicology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jaromir Michałowicz 

Number of co-investigators in the project: 6

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 330 000 PLN

Project start date (Y-m-d): 2013-07-12

Project end date (Y-m-d): 2017-01-11

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop biologiczny z kamerą.
  2. Wirówka Sigma 3K15 z rotorami (35 000 PLN)
  3. Mikropłytkowy, kinetyczny czytnik absorbancji.
  4. Wirówka mikrohematokrytowa (5 170 PLN)
  5. Spektrofotometr dwuwiązkowy z zestawem komputerowym i oprogramowaniem (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Bisphenol a-sources, toxicity and biotransformation
    Authors:
    Jaromir Michałowicz
    Academic press:
    Environmental Toxicology and Pharmacology (rok: 2014, tom: 37, strony: 738-758), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.etap.2014.02.003 - link to the publication
  2. Evaluation of DNA-damaging potential of bisphenol A and its selected analogs in human peripheral blood mononuclear cells (in vitro)
    Authors:
    Katarzyna Mokra, Agnieszka Kuźmińska-Surowaniec, Katarzyna Woźniak, Jaromir Michałowicz
    Academic press:
    Food and Chemical Toxicology (rok: 2017, tom: 100, strony: 62-69), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fct.2016.12.003 - link to the publication
  3. Bisphenol A and its analogs exhibit different apoptotic potential in peripheral blood mononuclear cells (in vitro study)
    Authors:
    Katarzyna Mokra, Magdalena Kocia, Jaromir Michałowicz
    Academic press:
    Food and Chemical and Toxicology (rok: 2015, tom: 84, strony: 79-88), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fct.2015.08.007 - link to the publication
  4. Bisphenol A and its analogues induce morphological and biochemical alterations in human peripheral blood mononuclear cells (in vitro study)
    Authors:
    Jaromir Michałowicz, Katarzyna Mokra, Agata Bąk
    Academic press:
    Toxicology in Vitro (rok: 2015, tom: 29, strony: 1464-1472), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2015.05.012 - link to the publication
  5. The in vitro comparative study of the effect of BPA, BPS, BPF and BPAF on human erythrocyte membrane; perturbations in membrane fluidity, alterations in conformational state and damage to proteins, changes in ATP level and Na+/K+ ATPase and AChE activities
    Authors:
    Aneta Maćczak, Piotr Duchnowicz, Paulina Sicińska, Maria Koter-Michalak, Bożena Bukowska, Jaromir Michałowicz
    Academic press:
    Food and Chemical Toxicology (rok: 2017, tom: 110, strony: 351-359), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.028 - link to the publication
  6. Comparative study of the effect of BPA and its selected analogues on hemoglobin oxidation, morphological alterations and hemolytic changes in human erythrocytes
    Authors:
    Aneta Maćczak, Bożena Bukowska, Jaromir Michalowicz
    Academic press:
    Comparative Biochemistry and Physiology, Part C (rok: 2015, tom: 176-177, strony: 62-70), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbpc.2015.07.008 - link to the publication
  7. Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study)
    Authors:
    Aneta Maćczak, Monika Cyrkler, Bożena Bukowska, Jaromir Michałowicz
    Academic press:
    Toxicology in Vitro (rok: 2017, tom: 41, strony: 143-149), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2017.02.018 - link to the publication
  8. Eryptosis-inducing activity of bisphenol A and its analogs in human red blood cells (in vitro study)
    Authors:
    Aneta Maćczak, Monika Cyrkler, Bożena Bukowska, Jaromir Michałowicz
    Academic press:
    Journal of Hazardous Materials (rok: 2016, tom: 307, strony: 328-335), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.hazmat.2015.12.057 - link to the publication
  9. Low-concentration exposure to BPA, BPF and BPAF induces oxidative DNA bases lesions in human peripheral blood mononuclear cells
    Authors:
    Katarzyna Mokra, Katarzyna Woźniak, Bożena Bukowska, Paulina Sicińska, Jaromir Michałowicz
    Academic press:
    Chemosphere (rok: 2018, tom: 201, strony: 119-126), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chemosphere.2018.02.166 - link to the publication

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