Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Cellular and molecular mechanism of action of PPI dendrimer complexes with nucleoside analogue anticancer drugs

2014/13/B/NZ3/04643

Keywords:

dendrimers nucleoside analogs anti-cancer therapy

Descriptors:

  • NZ3_1: Cell biology
  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Klajnert-Maculewicz 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 1 134 900 PLN

Project start date (Y-m-d): 2015-02-20

Project end date (Y-m-d): 2018-09-19

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (4)
  1. Mechanisms of internalization of maltose-modified poly(propyleneimine) glycodendrimers into leukemic cell lines
    Authors:
    M. Studzian, A. Szulc, A. Janaszewska, D. Appelhans, L. Pulaski, B. Klajnert-Maculewicz
    Academic press:
    Biomacromolecules (rok: 2017, tom: 18, strony: 1509-1520), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.biomac.7b00046 - link to the publication
  2. Sugar-modified poly(propylene imine) dendrimers as drug delivery agents for cytarabine to overcome drug resistance
    Authors:
    A. Szulc, L. Pulaski, D. Appelhans, B.Voit, B. Klajnert-Maculewicz
    Academic press:
    International Journal of Pharmaceutics (rok: 2016, tom: 513, strony: 572-583), Wydawca: ELSEVIER SCIENCE BV
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2016.09.063 - link to the publication
  3. Dendrimers as nanocarriers for nucleoside analogues.
    Authors:
    M. Gorzkiewicz, B. Klajnert-Maculewicz
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (rok: 2017, tom: 114, strony: 43-56), Wydawca: ELSEVIER SCIENCE BV
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2016.12.030 - link to the publication
  4. Fludarabine-specific molecular interactions with maltose-modified poly(propyleneimine) dendrimer enable effective cell entry of active drug form: comparison with clofarabine
    Authors:
    M. Gorzkiewicz, M. A. Deriu, M. Studzian, A. Janaszewska, G. Grasso, Ł. Pułaski, D. Appelhans, A. Danani, B. Klajnert-Maculewicz
    Academic press:
    Biomacromolecules (rok: 2019, tom: 20, strony: 1429-1442), Wydawca: ELSEVIER B.V.
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Sugar-modified poly(propylene imine) dendrimers stimulate the NF-κB pathway in a myeloid cell line.
    Authors:
    I. Jatczak-Pawlik, M. Gorzkiewicz, M. Studzian D. Appelhans, B. Voit, L. Pulaski, B. Klajnert-Maculewicz
    Academic press:
    Pharmaceutical Research (rok: 2017, tom: 34, strony: 136-147), Wydawca: SPRINGER/PLENUM PUBLISHERS
    Status:
    Published
    DOI:
    10.1007/s11095-016-2049-3 - link to the publication
  6. Effect of the Structure of Therapeutic Adenosine Analogues on Stability and Surface Electrostatic Potential of their Complexes with Poly(propyleneimine) Dendrimers
    Authors:
    M. Gorzkiewicz, D. Appelhans, S. Boye, A. Lederer, B. Voit, B. Klajnert-Maculewicz
    Academic press:
    Macromolecular Rapid Communications (rok: 2019, tom: 40, strony: 1900181), Wydawca: Wiley-VCH Verlag
    Status:
    Published
    DOI:
    10.1002/marc.201900181 - link to the publication
  7. Glycodendrimer nanocarriers for direct delivery of fludarabine triphosphate to leukemic cells: Improved pharmacokinetics and pharmacodynamics of fludarabine
    Authors:
    M. Gorzkiewicz, I. Jatczak-Pawlik, M. Studzian, L. Pulaski, D. Appelhans, B. Voit, B. Klajnert-Maculewicz
    Academic press:
    Biomacromolecules (rok: 2018, tom: 19, strony: 531-543), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.biomac.7b01650 - link to the publication
  8. Maltose modified poly(propylene imine) dendrimers as potential carriers of nucleoside analog 5'-triphosphates
    Authors:
    A. Szulc, M. Signorelli, A. Schiraldi, D. Appelhans, B. Voit, M. Bryszewska, B. Klajnert-Maculewicz
    Academic press:
    International Journal of Pharmaceutics (rok: 2015, tom: 495, strony: 940-947), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2015.09.065 - link to the publication
  9. Poly(propyleneimine) glycodendrimers non-covalently bind ATP in a pHand salt-dependent manner – model studies for adenosine analogue drug delivery
    Authors:
    M. Gorzkiewicz, A. Buczkowski, D. Appelhans, B. Voit, L. Pulaski, B. Palecz, B. Klajnert-Maculewicz
    Academic press:
    International Journal of Pharmaceutics (rok: 2018, tom: 544, strony: 83-90), Wydawca: ELSEVIER SCIENCE BV
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2018.03.063 - link to the publication
  10. Terminal Sugar Moiety Determines Immunomodulatory Properties of Poly(propyleneimine) Glycodendrimers
    Authors:
    M. Gorzkiewicz, K. Sztandera, I. Jatczak-Pawlik, R. Zinke, D. Appelhans, B. Klajnert-Maculewicz, L. Pulaski
    Academic press:
    Biomacromolecules (rok: 2018, tom: 19, strony: 1562-1572), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.biomac.8b00168 - link to the publication
  1. Maltose-modified poly(propyleneimine) dense shell dendrimers activate the NF-κB signaling pathway in THP-1 monocytic cell line
    Authors:
    M. Gorzkiewicz, I. Jatczak-Pawlik, M. Studzian, L. Pulaski, D. Appelhans, B. Voit, A. Janaszewska, B. Klajnert-Maculewicz
    Conference:
    5th International Symposium on Biomedical Applications of Dendrimers (rok: 2016, ), Wydawca: University of Copenhagen
    Data:
    konferencja 2-5 sierpnia 2016 r.
    Status:
    Published
  2. Sugar-modified PPI dendrimers as carriers of anti-leukemia drugs
    Authors:
    B. Klajnert-Maculewicz
    Conference:
    Glycobiology World Congress (rok: 2015, ), Wydawca: Proceedings of Glycobiology World Congress
    Data:
    konferencja 10-12 sierpnia 2015 r.
    Status:
    Published
  3. Biocompatibility-related chemical modifications of poly(propylene imine) dendrimers influence their interactions with Coomassie Brilliant Blue dye
    Authors:
    L. Pulaski, I. Jatczak-Pawlik, A. Janaszewska, D. Appelhans, B. Klajnert-Maculewicz
    Conference:
    8th International Conference on Chemistry and Chemical Process (rok: 2018, ), Wydawca: Hong Kong Chemical, Biological & Environmental Engineering Society
    Data:
    konferencja 23-25 lutego 2018 r.
    Status:
    Published
  4. PPI glycodendrimer as nanocarrier for fludarabine triphosphate to overcome drug resistance
    Authors:
    M. Gorzkiewicz
    Conference:
    Science: Polish Perspectives Berlin 2018 (rok: 2018, ), Wydawca: Polonium Foundation
    Data:
    konferencja 12-13 października 2018 r.
    Status:
    Published

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