Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Molecular mechanism of epigenetic drugs action to prevent multi-organ injury in a mouse model of sepsis

2014/14/M/NZ5/00462

Keywords:

sepsis epigenetic drugs transcription gene expression next-generation sequencing

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_9: Systems biology
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Mikula 

Number of co-investigators in the project: 7

Call: HARMONIA 6 - announced on 2014-06-16

Amount awarded: 1 977 000 PLN

Project start date (Y-m-d): 2015-06-08

Project end date (Y-m-d): 2019-12-07

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock
    Authors:
    Agnieszka Dreas, Katarzyna Kucwaj-Brysz, Karolina Pyziak, Urszula Kulesza, Ewelina Wincza, Charles-Henry Fabritius, Kinga Michalik, Ewelina Gabor-Worwa, Aniela Gołas, Mariusz Milik, Magdalena Masiejczyk, Eliza Majewska, Kazimiera Pyśniak, Urszula Wójcik-Trechcińska, Zuzanna Sandowska-Markiewicz, Krzysztof Brzózka, Jerzy Ostrowski, Tomasz Rzymski, Michal Mikula
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2021, tom: 213, strony: 113057), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2020.113057 - link to the publication
  2. Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models
    Authors:
    Michal Kopczynski, Izabela Rumienczyk, Maria Kulecka, Małgorzata Statkiewicz, Kazimiera Pysniak, Zuzanna Sandowska-Markiewicz, Urszula Wojcik-Trechcinska, Krzysztof Goryca, Karolina Pyziak, Eliza Majewska, Magdalena Masiejczyk, Katarzyna Wojcik-Jaszczynska, Tomasz Rzymski, Karol Bomsztyk, Jerzy Ostrowski, Michal Mikula
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 10204), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221910204 - link to the publication
  3. Multi-organ transcriptome dynamics in a mouse model of cecal ligation and puncture induced polymicrobial sepsis
    Authors:
    Izabela Rumienczyk, Maria Kulecka, Jerzy Ostrowski, Daniel Mar, Karol Bomsztyk, Stephen W Standage, Michal Mikula
    Academic press:
    Journal of Inflammation Research (rok: 2021, tom: 14, strony: 2377—2388), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/JIR.S307305 - link to the publication

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