Molecular mechanism of epigenetic drugs action to prevent multi-organ injury in a mouse model of sepsis
2014/14/M/NZ5/00462
Keywords
Descriptors
- NZ2_2: Genomika, transkryptomika i epigenomika
- NZ2_9: Biologia systemowa
- NZ5_7: Leczenie chorób człowieka
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 7
Call
HARMONIA 6 – announced on 2014-06-16
- Amount awarded
- 1 977 000 PLN
- Project start date
- 2015-06-08
- Project end date
- 2019-12-07
- Project duration
- 54 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (3)
-
Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models
- Authors:
- Michal Kopczynski, Izabela Rumienczyk, Maria Kulecka, Małgorzata Statkiewicz, Kazimiera Pysniak, Zuzanna Sandowska-Markiewicz, Urszula Wojcik-Trechcinska, Krzysztof Goryca, Karolina Pyziak, Eliza Majewska, Magdalena Masiejczyk, Katarzyna Wojcik-Jaszczynska, Tomasz Rzymski, Karol Bomsztyk, Jerzy Ostrowski, Michal Mikula
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 10204), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms221910204 – link to the publication
-
Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock
- Authors:
- Agnieszka Dreas, Katarzyna Kucwaj-Brysz, Karolina Pyziak, Urszula Kulesza, Ewelina Wincza, Charles-Henry Fabritius, Kinga Michalik, Ewelina Gabor-Worwa, Aniela Gołas, Mariusz Milik, Magdalena Masiejczyk, Eliza Majewska, Kazimiera Pyśniak, Urszula Wójcik-Trechcińska, Zuzanna Sandowska-Markiewicz, Krzysztof Brzózka, Jerzy Ostrowski, Tomasz Rzymski, Michal Mikula
- Academic press:
- European Journal of Medicinal Chemistry (year: 2021, volume: 213, pages: 113057), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ejmech.2020.113057 – link to the publication
-
Multi-organ transcriptome dynamics in a mouse model of cecal ligation and puncture induced polymicrobial sepsis
- Authors:
- Izabela Rumienczyk, Maria Kulecka, Jerzy Ostrowski, Daniel Mar, Karol Bomsztyk, Stephen W Standage, Michal Mikula
- Academic press:
- Journal of Inflammation Research (year: 2021, volume: 14, pages: 2377—2388), Publisher: Dove Medical Press
- Status:
- Published
- DOI:
- 10.2147/JIR.S307305 – link to the publication