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Role of the endocannabionoid system in the pathogenesis of depression and in the mechanism of action of antidepressant drugs.

2012/05/B/NZ7/02589

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ7_3: Promocja zdrowia, kultura fizyczna

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Małgorzata Maria Filip

Number of co-investigators in the project: 4

Call

OPUS 3 – announced on 2012-03-15

Amount awarded
341 600 PLN
Project start date
2013-01-31
Project end date
2016-01-30
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. LODÓWKA.
  2. POMPA PRÓŻNIOWA DO SPE.
  3. WAGA ANALITYCZNA. Cost: 5 000 PLN
  4. WYTRZĄSARKA DO EPENDORFÓW. Cost: 5 000 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Changes in the Brain Endocannabinoid System in Rat Models of Depression.

    Authors:
    Smaga I, Jastrzębska J, Zaniewska M, Bystrowska B, Gawliński D, Faron-Górecka A, Broniowska Ż, Miszkiel J, Filip M.
    Academic press:
    Neurotocity Research (year: 2017, volume: 31, pages: 421-435), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-017-9708-y – link to the publication

  2. Cannabinoid Ligands and Alcohol Addiction: A Promising Therapeutic Tool or a Humbug?

    Authors:
    Kleczkowska P, Smaga I, Filip M, Bujalska-Zadrozny M.
    Academic press:
    Neurotoxicity Research (year: 2016, volume: 29, pages: 173-96), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-015-9555-7 – link to the publication

  3. The endocannabinoid/endovanilloid system and depression

    Authors:
    Irena Smaga, Beata Bystrowska, Dawid Gawlinski, Edmund Przegalinski, Małgorzata Filip
    Academic press:
    Current Neuropharmacology (year: 2014, volume: 12, pages: 462-474), Publisher: Bentham
    Status:
    Published
    DOI:
    10.2174/1570159X12666140923205412 – link to the publication

  4. Changes in the cannabinoids receptors in rats following treatment with antidepressants.

    Authors:
    Smaga I, Zaniewska M, Gawliński D, Faron-Górecka A, Szafrański P, Cegła M, Filip M.
    Academic press:
    Neurotoxicology (year: 2017, volume: 63, pages: 13-20), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuro.2017.08.012 – link to the publication

  5. Clinical/Therapeutic Approaches for Cannabinoid Ligands in Central and Peripheral Nervous System Diseases: Mini Review

    Authors:
    Fijal K, Filip M
    Academic press:
    Clinical Neuropharmacology (year: 2016, volume: 23, pages: 222), Publisher: springer
    Status:
    Published

  6. Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism.

    Authors:
    Smaga I, Niedzielska E, Gawlik M, Moniczewski A, Krzek J, Przegaliński E, Pera J, Filip M.
    Academic press:
    Pharmacol Rep. (year: 2015, volume: 67, pages: 569-80), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2014.12.015 – link to the publication

  7. Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures

    Authors:
    Irena Smaga, Beata Bystrowska, Dawid Gawliński, Bartosz Pomierny, Piotr Stankowicz, Małgorzata Filip
    Academic press:
    Neurotoxicity Research (year: 2014, volume: 26, pages: 190-206), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-014-9465-0. – link to the publication

Articles in post-conference publications (9)

  1. Changes in the level of endocannabinoids and endocannabinoid-like molecules after acute and repeated administration of escitalopram or FAAH inhibitor in rat brain structures

    Authors:
    Smaga I, Bystrowska B, Pomierny B, Krzyżanowska W, Filip M.
    Conference:
    18th INTERNATIONAL CONGRESS OF THE POLISH PHARMACOLOGICAL SOCIETY (Kazimierz Dolny) (year: 2013, pages: Vol. 65, str. 135-136), Publisher: Pharmacological Reports
    Date:
    conference 23-25.05.
    Status:
    Published
    DOI:
    link to the publication

  2. Changes in the level of endocannabinoids after acute and repeated administration of imipramine with simultaneous blockade of CB1 receptors in different rat brain structures

    Authors:
    Irena Smaga, Beata Bystrowska, Ewelina Galus, Dominika Kardaś, Małgorzata Filip
    Conference:
    NEURONUS IBRO&IRUN Neuroscience Forum (year: 2014, pages: 60), Publisher: NEURONUS IBRO&IRUN
    Date:
    conference 25-27.04
    Status:
    Published
    DOI:
    link to the publication

  3. Effects of acute and repeated administration of escitalopram and FAAH inhibitor on the level of endocannabinoids and endocannabinoid-like molecules in different rat brain structures

    Authors:
    Irena Smaga, Beata Bystrowska, Irmina Turek, Małgorzata Filip
    Conference:
    6th EUROPEAN WORKSHOP ON CANNABINOID RESEARCH,18-20.04.2013, DUBLIN, IRLANDIA (year: 2013, pages: 45), Publisher: British Pharmacological Society
    Date:
    conference 18-20.04
    Status:
    Published
    DOI:
    link to the publication

  4. Effects of chronic antidepressant treatment under blockade of CB2 receptors on the level of endocannabinoids in rat brain structures

    Authors:
    Irena Smaga, Lucyna Pomierny-Chamioło, Beata Bystrowska, Tasnim Mohaissen, Karolina Kot, Małgorzata Filip
    Conference:
    EUROTOX 2015, 51 KONGRES EUROPEJSKIEGO TOWARZYSTWA TOKSYKOLOGICZNEGO, Porto, Portugalia (year: 2015, pages: 381-382), Publisher: Toxicology Letters
    Date:
    conference 13-16.09
    Status:
    Published
    DOI:
    link to the publication

  5. Effects of acute administration of antidepressants with simultaneous blockade of cannabinoid CB2 receptors on the endocannabinoid levels in rat brain structures

    Authors:
    Irena Smaga, Beata Bystrowska, Lucyna Pomierny-Chamioło, Tasnim Mohaissen, Karolina Kot, Małgorzata Filip
    Conference:
    EUROTOX 2015, 51 KONGRES EUROPEJSKIEGO TOWARZYSTWA TOKSYKOLOGICZNEGO, Porto, Portugalia (year: 2015, pages: 380), Publisher: Toxicology Letters
    Date:
    conference 13-16.09
    Status:
    Published
    DOI:
    link to the publication

  6. Changes in the level of endocannabinoids after acute and repeated administration of tianeptine with simultaneous blockade of CB2 receptors in different rat brain structures

    Authors:
    Karolina Kot, Irena Smaga, Tasnim Mohaissen, Dawid Gawliński, Małgorzata Filip
    Conference:
    NEURONUS IBRO&IRUN Neuroscience Forum, Kraków, Polska (year: 2015, pages: 55), Publisher: NEURONUS IBRO&IRUN Neuroscience Forum
    Date:
    conference 17-19.04
    Status:
    Published
    DOI:
    link to the publication

  7. Changes in the level of endocannabinoids and endocannabinoid-like molecules in different brain structures in animal models of depression

    Authors:
    Irena Smaga, Dawid Gawliński, Beata Bystrowska, Joanna Jastrzębska, Małgorzata Frankowska, Małgorzata Filip
    Conference:
    19th INTERNATIONAL MEDICAL ESPERANTO CONGRESS & 1st CENTRAL EUROPEAN BIOMEDICAL CONGRESS, Budapeszt, Węgry (year: 2014, pages: 156), Publisher: Universal Medical Esperanto Association Budapest-Cracow
    Date:
    conference 16-20.07.2014
    Status:
    Published
    DOI:
    link to the publication

  8. Rola układu endokanabinoidowego w zwierzęcych modelach depresji

    Authors:
    Irena Smaga-Maślanka, Joanna Jastrzębska, Beata Bystrowska, Małgorzata Filip
    Conference:
    V KONFERENCJA NAUKOWA DOKTORANTÓW WYDZIAŁU LEKARSKIEGO I FARMACEUTYCZNEGO UJ CM, Kraków, Polska (year: 2015, pages: 197), Publisher: Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego
    Date:
    conference 28-29.05
    Status:
    Published
    DOI:
    link to the publication

  9. Changes in the level of endocannabinoids after acute and repeated administration of imipramine with simultaneous blockade of CB2 receptors in different rat brain structures

    Authors:
    Tasnim Mohaissen, Irena Smaga, Karolina Kot, Małgorzata Filip
    Conference:
    NEURONUS IBRO&IRUN Neuroscience Forum, Kraków, Polska (year: 2015, pages: 60), Publisher: NEURONUS IBRO&IRUN Neuroscience Forum
    Date:
    conference 17-19.04
    Status:
    Published
    DOI:
    link to the publication

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