Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of the endocannabionoid system in the pathogenesis of depression and in the mechanism of action of antidepressant drugs.

2012/05/B/NZ7/02589

Keywords:

depression antidepressants the endocannabinoid system liquid chromatography mass spectrometry autoradiography

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_3: Physical culture and health promotion

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Filip 

Number of co-investigators in the project: 4

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 341 600 PLN

Project start date (Y-m-d): 2013-01-31

Project end date (Y-m-d): 2016-01-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. WAGA ANALITYCZNA (5 000 PLN)
  2. POMPA PRÓŻNIOWA DO SPE.
  3. WYTRZĄSARKA DO EPENDORFÓW (5 000 PLN)
  4. LODÓWKA.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (9)
  1. Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures
    Authors:
    Irena Smaga, Beata Bystrowska, Dawid Gawliński, Bartosz Pomierny, Piotr Stankowicz, Małgorzata Filip
    Academic press:
    Neurotoxicity Research (rok: 2014, tom: 26, strony: 190-206), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-014-9465-0. - link to the publication
  2. Clinical/Therapeutic Approaches for Cannabinoid Ligands in Central and Peripheral Nervous System Diseases: Mini Review
    Authors:
    Fijal K, Filip M
    Academic press:
    Clinical Neuropharmacology (rok: 2016, tom: 23, strony: 222), Wydawca: springer
    Status:
    Published
    DOI:
    brak - link to the publication
  3. The endocannabinoid/endovanilloid system and depression
    Authors:
    Irena Smaga, Beata Bystrowska, Dawid Gawlinski, Edmund Przegalinski, Małgorzata Filip
    Academic press:
    Current Neuropharmacology (rok: 2014, tom: 12, strony: 462-474), Wydawca: Bentham
    Status:
    Published
    DOI:
    10.2174/1570159X12666140923205412 - link to the publication
  4. Cannabinoid Ligands and Alcohol Addiction: A Promising Therapeutic Tool or a Humbug?
    Authors:
    Kleczkowska P, Smaga I, Filip M, Bujalska-Zadrozny M.
    Academic press:
    Neurotoxicity Research (rok: 2016, tom: 29, strony: 173-96), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-015-9555-7 - link to the publication
  5. Changes in the Brain Endocannabinoid System in Rat Models of Depression.
    Authors:
    Smaga I, Jastrzębska J, Zaniewska M, Bystrowska B, Gawliński D, Faron-Górecka A, Broniowska Ż, Miszkiel J, Filip M.
    Academic press:
    Neurotocity Research (rok: 2017, tom: 31, strony: 421-435), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-017-9708-y - link to the publication
  6. Changes in the cannabinoids receptors in rats following treatment with antidepressants.
    Authors:
    Smaga I, Zaniewska M, Gawliński D, Faron-Górecka A, Szafrański P, Cegła M, Filip M.
    Academic press:
    Neurotoxicology (rok: 2017, tom: 63, strony: 13-20), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuro.2017.08.012 - link to the publication
  7. Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism.
    Authors:
    Smaga I, Niedzielska E, Gawlik M, Moniczewski A, Krzek J, Przegaliński E, Pera J, Filip M.
    Academic press:
    Pharmacol Rep. (rok: 2015, tom: 67, strony: 569-80), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2014.12.015 - link to the publication
  1. Changes in the level of endocannabinoids and endocannabinoid-like molecules in different brain structures in animal models of depression
    Authors:
    Irena Smaga, Dawid Gawliński, Beata Bystrowska, Joanna Jastrzębska, Małgorzata Frankowska, Małgorzata Filip
    Conference:
    19th INTERNATIONAL MEDICAL ESPERANTO CONGRESS & 1st CENTRAL EUROPEAN BIOMEDICAL CONGRESS, Budapeszt, Węgry (rok: 2014, ), Wydawca: Universal Medical Esperanto Association Budapest-Cracow
    Data:
    konferencja 16-20.07.2014
    Status:
    Published
    DOI:
    link to the publication
  2. Effects of acute and repeated administration of escitalopram and FAAH inhibitor on the level of endocannabinoids and endocannabinoid-like molecules in different rat brain structures
    Authors:
    Irena Smaga, Beata Bystrowska, Irmina Turek, Małgorzata Filip
    Conference:
    6th EUROPEAN WORKSHOP ON CANNABINOID RESEARCH,18-20.04.2013, DUBLIN, IRLANDIA (rok: 2013, ), Wydawca: British Pharmacological Society
    Data:
    konferencja 18-20.04
    Status:
    Published
    DOI:
    link to the publication
  3. Changes in the level of endocannabinoids after acute and repeated administration of imipramine with simultaneous blockade of CB2 receptors in different rat brain structures
    Authors:
    Tasnim Mohaissen, Irena Smaga, Karolina Kot, Małgorzata Filip
    Conference:
    NEURONUS IBRO&IRUN Neuroscience Forum, Kraków, Polska (rok: 2015, ), Wydawca: NEURONUS IBRO&IRUN Neuroscience Forum
    Data:
    konferencja 17-19.04
    Status:
    Published
    DOI:
    link to the publication
  4. Changes in the level of endocannabinoids after acute and repeated administration of tianeptine with simultaneous blockade of CB2 receptors in different rat brain structures
    Authors:
    Karolina Kot, Irena Smaga, Tasnim Mohaissen, Dawid Gawliński, Małgorzata Filip
    Conference:
    NEURONUS IBRO&IRUN Neuroscience Forum, Kraków, Polska (rok: 2015, ), Wydawca: NEURONUS IBRO&IRUN Neuroscience Forum
    Data:
    konferencja 17-19.04
    Status:
    Published
    DOI:
    link to the publication
  5. Changes in the level of endocannabinoids and endocannabinoid-like molecules after acute and repeated administration of escitalopram or FAAH inhibitor in rat brain structures
    Authors:
    Smaga I, Bystrowska B, Pomierny B, Krzyżanowska W, Filip M.
    Conference:
    18th INTERNATIONAL CONGRESS OF THE POLISH PHARMACOLOGICAL SOCIETY (Kazimierz Dolny) (rok: 2013, ), Wydawca: Pharmacological Reports
    Data:
    konferencja 23-25.05.
    Status:
    Published
    DOI:
    link to the publication
  6. Effects of acute administration of antidepressants with simultaneous blockade of cannabinoid CB2 receptors on the endocannabinoid levels in rat brain structures
    Authors:
    Irena Smaga, Beata Bystrowska, Lucyna Pomierny-Chamioło, Tasnim Mohaissen, Karolina Kot, Małgorzata Filip
    Conference:
    EUROTOX 2015, 51 KONGRES EUROPEJSKIEGO TOWARZYSTWA TOKSYKOLOGICZNEGO, Porto, Portugalia (rok: 2015, ), Wydawca: Toxicology Letters
    Data:
    konferencja 13-16.09
    Status:
    Published
    DOI:
    link to the publication
  7. Effects of chronic antidepressant treatment under blockade of CB2 receptors on the level of endocannabinoids in rat brain structures
    Authors:
    Irena Smaga, Lucyna Pomierny-Chamioło, Beata Bystrowska, Tasnim Mohaissen, Karolina Kot, Małgorzata Filip
    Conference:
    EUROTOX 2015, 51 KONGRES EUROPEJSKIEGO TOWARZYSTWA TOKSYKOLOGICZNEGO, Porto, Portugalia (rok: 2015, ), Wydawca: Toxicology Letters
    Data:
    konferencja 13-16.09
    Status:
    Published
    DOI:
    link to the publication
  8. Rola układu endokanabinoidowego w zwierzęcych modelach depresji
    Authors:
    Irena Smaga-Maślanka, Joanna Jastrzębska, Beata Bystrowska, Małgorzata Filip
    Conference:
    V KONFERENCJA NAUKOWA DOKTORANTÓW WYDZIAŁU LEKARSKIEGO I FARMACEUTYCZNEGO UJ CM, Kraków, Polska (rok: 2015, ), Wydawca: Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego
    Data:
    konferencja 28-29.05
    Status:
    Published
    DOI:
    link to the publication
  9. Changes in the level of endocannabinoids after acute and repeated administration of imipramine with simultaneous blockade of CB1 receptors in different rat brain structures
    Authors:
    Irena Smaga, Beata Bystrowska, Ewelina Galus, Dominika Kardaś, Małgorzata Filip
    Conference:
    NEURONUS IBRO&IRUN Neuroscience Forum (rok: 2014, ), Wydawca: NEURONUS IBRO&IRUN
    Data:
    konferencja 25-27.04
    Status:
    Published
    DOI:
    link to the publication

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