Functionalized carbohydrates pharmacophores as a putative antituberculosis drugs - the mechanism of action.
2014/15/B/NZ7/01002
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_16: Inne zagadnienia pokrewne
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Instytut Biologii Medycznej PAN
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 8 – announced on 2014-09-15
- Amount awarded
- 610 700 PLN
- Project start date
- 2015-09-02
- Project end date
- 2019-03-01
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Nefelometr. Cost: 25 000 PLN
- Podręczny detektor wzrostu prątków gruźlicy (BACTEC Micro MGIT). Cost: 5 000 PLN
- Wirówka laboratoryjna (stołowa) z chłodzeniem wraz z rotorem stałokątowym.
- autoklaw. Cost: 10 000 PLN
Information in the final report
Publication in academic press/journals (5)
-
Mycobacterial DNA Replication as a Target for Antituberculosis Drug Discovery.
- Authors:
- Płocinska R, Korycka-Machala M, Plocinski P, Dziadek J.
- Academic press:
- Current Topics in Medicinal Chemistry (year: 2017, volume: 17, pages: 2129-2142), Publisher: BENTHAM SCIENCE PUBL LTD
- Status:
- Published
- DOI:
- 10.2174/1568026617666170130114342 – link to the publication
-
1H-benzo[d]imidazole derivatives target MmpL3 in Mycobacterium tuberculosis
- Authors:
- Małgorzata Korycka-Machała, Albertus Viljoen, Paulina Borówka, Bożena Dziadek, Katarzyna Gobis, Anna Brzostek, Malwina Kawka, Mickael Blaise, Jakub Pawełczyk, Dominik Strapagiel, Laurent Kremer and Jarosław Dziadek
- Academic press:
- Antimicrobial agents and chemiotherapy (year: 2019, volume: 63(10), pages: e00441-19), Publisher: American Society for Microbiology
- Status:
- Published
- DOI:
- 10.1128/AAC.00441-19 – link to the publication
-
Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli.
- Authors:
- Korycka-Machala M, Nowosielski M, Kuron A, Rykowski S, Olejniczak A, Hoffmann M, Dziadek J.
- Academic press:
- Molecules (year: 2017, volume: 22, pages: pii.E154), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/molecules22010154 – link to the publication
-
Evaluation of the Mycobactericidal Effect of Thio-functionalized Carbohydrate Derivatives.
- Authors:
- Korycka-Machała M, Brzostek A, Dziadek B, Kawka M, Popławski T, Witczak ZJ, Dziadek J.
- Academic press:
- Molecules (year: 2017, volume: 22, pages: E812), Publisher: MDPI AG
- Status:
- Published
- DOI:
- 10.3390/molecules22050812. – link to the publication
-
Tiocukry jako leki
- Authors:
- Sarnik J, Czubatka-Bieńkowska A, Dziadek J, Witczak ZJ, Popławski T.
- Academic press:
- Postępy Biochemii (year: 2016, volume: 62, pages: 526-534), Publisher: Polskie Towarzystwo Biochemiczne
- Status:
- Published