Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of the structural and functional mechanisms of action of the nicotinic receptors modulators.

2013/09/D/NZ7/04549

Keywords:

nicotinic receptors allosteric modulation positive allosteric modulators learning and memory novel furan-2-yl-acrylamide derivatives

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Targowska-Duda 

Number of co-investigators in the project: 5

Call: SONATA 5 - announced on 2013-03-15

Amount awarded: 461 950 PLN

Project start date (Y-m-d): 2014-03-12

Project end date (Y-m-d): 2017-09-11

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer (5 000 PLN)
  2. Licencja programu YASARA Structure.
  3. Homogenizator (5 000 PLN)
  4. Komputer przenośny.
  5. Labirynt EPM dla myszy (1 968 PLN)
  6. Dwuletnia licencja programu Molegro Virtual Docker (MVD) (10 000 PLN)
  7. Pehametr (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.
    Authors:
    Arias HR, Ravazzini F, Targowska-Duda KM, Kaczor AA, Feuerbach D, Boffi JC, Draczkowski P, Montag D, Brown BM, Elgoyhen AB, Jozwiak K, Puia G2
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2016, tom: 76, strony: 19-30), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biocel.2016.04.015. - link to the publication
  2. The antidepressant-like activity of nicotine, but not of 3-furan-2-yl-N-p-tolyl-acrylamide, is regulated by the nicotinic receptor β4 subunit
    Authors:
    Arias HR, Targowska-Duda KM, Feuerbach D, Jozwiak K
    Academic press:
    Neurochem International (rok: 2015, tom: 87, strony: 110-6), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.neuint.2015.06.006 - link to the publication
  3. Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites
    Authors:
    Arias HR, Targowska-Duda KM, Feuerbach D, Jozwiak K
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2015, tom: 65:81-90, strony: 81-90), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biocel.2015.05.015 - link to the publication
  4. Antidepressant activity in mice elicited by 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor
    Authors:
    Targowska-Duda KM, Feuerbach D, Biala G, Jozwiak K, Arias HR
    Academic press:
    Neuroscience Letters (rok: 2014, tom: 569, strony: 126-30), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.neulet.2014.03.067 - link to the publication
  5. N,6-dimethyltricyclo[5.2.1.02,6]decan-2-amine Enantiomers Interact with Luminal and Non-luminal Domains at the Human α3β4 Nicotinic Acetylcholine Receptor
    Authors:
    Arias HR, Targowska-Duda KM , Jozwiak K
    Academic press:
    Journal of Biochemistry and Molecular Biology Research (rok: 2015, tom: 1(1), strony: 45293), Wydawca: Open Journal System
    Status:
    Published
    DOI:
    10.6051/j.issn.2313-7177.2015.01.1 - link to the publication
  6. The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors in Mice
    Authors:
    Bagdas D, Targowska-Duda KM, López JJ, Perez EG, Arias HR, Damaj MI
    Academic press:
    Anesthesia and analgesia (rok: 2015, tom: 121(5), strony: 1369-77), Wydawca: The International Society for Anaesthetic Pharmacology
    Status:
    Published
    DOI:
    10.1213/ANE.0000000000000902. - link to the publication
  7. 3-Furan-2-yl-N-p-tolyl-acrylamide, a highly selective positive allosteric modulator of α7 nicotinic receptors, produces anxiolytic-like activity in mice
    Authors:
    Targowska-Duda KM, Budzynska B, Michalak A, Jozwiak K, Biala G, Arias HR.
    Academic press:
    Journal of Psychopharmacology (rok: 2019, tom: 33(5), strony: 558-567), Wydawca: SAGE journals
    Status:
    Published
    DOI:
    10.1177/0269881118821100 - link to the publication
  8. Pharmacological and molecular studies on the interaction of varenicline with different nicotinic acetylcholine receptor subtypes. Potential mechanism underlying partial agonism at human α4β2 and α3β4 subtypes
    Authors:
    Arias HR, Feuerbach D, Targowska-Duda K, Kaczor AA, Poso A, Jozwiak K
    Academic press:
    Biochimica et Biophysica Acta Biomembranes (rok: 2015, tom: 1848(2), strony: 731-41), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2014.11.003 - link to the publication
  9. Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine receptor: an in silico study
    Authors:
    Targowska-Duda KM, Kaczor AA, Jozwiak K, Arias HR
    Academic press:
    Journal of Biomolecular Structure and Dynamics (rok: 2019, tom: 37(2), strony: 411-439), Wydawca: Taylor and Francis Online
    Status:
    Published
    DOI:
    10.1080/07391102.2018.1427634 - link to the publication
  10. The positive allosteric modulator of α7 nicotinic acetylcholine receptors, 3-furan-2-yl-N-p-tolyl-acrylamide, enhances memory processes and stimulates ERK1/2 phosphorylation in mice
    Authors:
    Targowska-Duda KM, Wnorowski A, Budzynska B, Jozwiak K, Biala G, Arias HR
    Academic press:
    Behavioural Brain Research (rok: 2016, tom: 302, strony: 142-51), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbr.2016.01.002 - link to the publication

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